| Accession | GenProp0148 |
| Name | release factor 2 programmed frameshift |
| Type | SYSTEM |
| Description | Peptide chain release factor 2, product of the prfB gene (RF2, or PrfB), often has a programmed frameshift. When enough RF2 is present, translation ends at a UGA (amber) stop codon soon after the start. Without sufficient RF2, a translational frameshift occurs, allowing RF2 to be made. UGA codons also play a role in selenocysteine incorporation, but the programmed frameshift in the prfB gene appears much more widespread than selenocysteine incorporation. |
| JCVI Role | Translation factors |
| Parent Property | GenProp0197: protein biosynthesis
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| Literature References | [ 1 ]Persson BC, Atkins JF. Does disparate occurrence of autoregulatory programmed frameshifting in decoding the release factor 2 gene reflect an ancient origin with loss in independent lineages? J Bacteriol. 1998 Jul;180(13):3462-6. PMID 9642202
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