Genome Property Definition Page
Accession | GenProp0312 | |
Name | pyrrolysine | |
Type | SYSTEM | |
Description | In methanogens, methylamine methyltransferases have an in-frame TAG codon that is translated with a lysine amide-linked to (4R,5R)-4-substituted-pyrroline-5-carboxylate. This residue is called pyrrolysine, and is considered the 22nd amino acid, where selenocysteine is the 21st. Pyrrrolysine occurs also in Desulfitobacterium hafniense and related species; proteins in which pyrrolysine occurs are not necessarily homologous to each other. A three-gene cassette, pylBCD, produces the pyrrolysine prior to its attachment to its cognate tRNA. | |
Parent Property | GenProp0197: protein biosynthesis | |
Literature References |
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Components
Step Name | Step Num | Required | Evidence (Method) | Evidence Go Terms |
---|---|---|---|---|
example | YES | pyrrolysine-containing (com_name) | ||
pyrrolysine biosynthesis radical SAM protein | pylB | YES | TIGR03910 (HMM): pyrrolysine biosynthesis radical SAM protein | |
pyrrolysine biosynthesis protein PylC | pylC | YES | TIGR03909 (HMM): pyrrolysine biosynthesis protein PylC | |
pyrrolysine biosynthesis protein PylD | pylD | YES | TIGR03911 (HMM): pyrrolysine biosynthesis protein PylD | |
pyrrolysyl-tRNA synthetase, C-terminal region | pylSc | YES | TIGR02367 (HMM): pyrrolysine--tRNA ligase, C-terminal region | |
pyrrolysyl-tRNA synthetase, N-terminal region | pylSn | YES | TIGR03912 (HMM): pyrrolysine--tRNA ligase, N-terminal region | |
pyrrolysine tRNA | pylT | YES | tRNA-PyL (RNA) |
Parent Properties
Accession | Name |
---|---|
GenProp0197 | protein biosynthesis |
Sibling Properties
Accession | Name |
---|---|
GenProp0016 | selenocysteine system |
GenProp0132 | transcription termination - antitermination Nus factors |
GenProp0148 | release factor 2 programmed frameshift |
GenProp0174 | ribosome, bacterial, large subunit |
GenProp0175 | ribosome, bacterial, small subunit |
GenProp0188 | GatABC aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase complex |
GenProp0189 | tRNA-Gln direct aminoacylation |
GenProp0211 | tmRNA trans-translation system |
GenProp0258 | tRNA aminoacylation |
GenProp0259 | tRNA-Asn direct aminoacylation |
GenProp0304 | cysteine biosynthesis, tRNA-dependent |
GenProp0634 | Sigma-54 (RpoN) systems |
GenProp0692 | selenouridine-containing tRNA |
GenProp0704 | tRNA U34 carboxymethylaminomethyl modification |
GenProp0740 | translation initiation, bacterial |
GenProp0741 | translation elongation, bacterial |
GenProp0746 | translation termination, bacterial |
GenProp0812 | rho-dependent termination |