Genome Property Definition Page

Nameselenouridine-containing tRNA
DescriptionSelenium may occur in cells both in proteins, in the form of selenocysteine, and in tRNA, in the form of 2-selenouridine. The two incorporation systems both rely on the selenium donor protein, selenide-water dikinase. This property describes the two-gene combination of selenide-water dikinase and tRNA 2-selenouridine synthase. Note that an initial sulfurtransferase reaction must proceed the action of 2-selenouridine synthase; the enzyme(s) responsible is not currently included in the definition of this Genome Property.
JCVI RoletRNA and rRNA base modification
Parent PropertyGenProp0197: protein biosynthesis
GenProp0819: RNA metabolism
Literature References
[ 1 ]Wolfe MD, Ahmed F, Lacourciere GM, Lauhon CT, Stadtman TC, Larson TJ  Functional diversity of the rhodanese homology domain: the Escherichia coli ybbB gene encodes a selenophosphate-dependent tRNA 2-selenouridine synthase.  J Biol Chem. 2004 Jan 16;279(3):1801-9. Epub 2003 Oct 31.  PMID 14594807
[ 2 ]Romero H, Zhang Y, Gladyshev VN, Salinas G  Evolution of selenium utilization traits.  Genome Biol. 2005;6(8):R66. Epub 2005 Jul 27.  PMID 16086848
[ 3 ]Su D, Ojo TT, Soll D, Hohn MJ  Selenomodification of tRNA in archaea requires a bipartite rhodanese enzyme.  FEBS Lett. 2012 Mar 23;586(6):717-21. doi: 10.1016/j.febslet.2012.01.024.  PMID 22293502
Gene Ontology TermGO:0001887: selenium compound metabolic process (biological_process)
GO:0006400: tRNA modification (biological_process)

Step NameStep NumRequiredEvidence (Method)Evidence Go Terms
selenide, water dikinasedonorYESTIGR00476 (HMM): selenide, water dikinaseGO:0006400: tRNA modification
GO:0001887: selenium compound metabolic process
2-selenouridine synthasesynthYESTIGR03167 (HMM): tRNA 2-selenouridine synthaseGenProp1105 (GENPROP): bipartite SelU (archaeal)
GO:0006400: tRNA modification
GO:0001887: selenium compound metabolic process
GO:0006400: tRNA modification
GO:0001887: selenium compound metabolic process

Parent Properties
GenProp0197protein biosynthesis
GenProp0819RNA metabolism

Sibling Properties
GenProp0016selenocysteine system
GenProp0132transcription termination - antitermination Nus factors
GenProp0148release factor 2 programmed frameshift
GenProp0174ribosome, bacterial, large subunit
GenProp0175ribosome, bacterial, small subunit
GenProp0188GatABC aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase complex
GenProp0189tRNA-Gln direct aminoacylation
GenProp0211tmRNA trans-translation system
GenProp0258tRNA aminoacylation
GenProp0259tRNA-Asn direct aminoacylation
GenProp0304cysteine biosynthesis, tRNA-dependent
GenProp0634Sigma-54 (RpoN) systems
GenProp0704tRNA U34 carboxymethylaminomethyl modification
GenProp0740translation initiation, bacterial
GenProp0741translation elongation, bacterial
GenProp0746translation termination, bacterial
GenProp0812rho-dependent termination
GenProp0262RNA polymerase, bacterial
GenProp04826S RNA (eubacterial RNA polymerase regulator)
GenProp0677queuosine (Q-tRNA) biosynthesis from preQ0
GenProp0898RNA ligase/unknown protein pair
GenProp0948RNA repair, Hen1/Pnkp system
GenProp1060tRNA N6-threonylcarbamoyladenosine modification
GenProp1077tRNA(Pro) cmo5UGG modification
GenProp108216S rRNA C1402 m(4)Cm modification