Genome Property Definition Page
| Accession | GenProp0704 |
| Name | tRNA U34 carboxymethylaminomethyl modification |
| Type | PATHWAY |
| Description | GidA and MnmE act as a heterotetramer for the cmnmU34 modification in bacteria and eukarya. They are absent from the Archaea. Their action may be followed by that of the bifunctional MnmC (YfcK) protein. |
| JCVI Role | tRNA and rRNA base modification |
| Parent Property | GenProp0197: protein biosynthesis GenProp0819: RNA metabolism |
Components
| Step Name | Step Num | Required | Evidence (Method) | Evidence Go Terms |
|---|---|---|---|---|
| U34 modification protein GidA | GidA | YES | TIGR00136 (HMM): tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA | |
| cysteine desulfurase IscS | IscS | YES | TIGR02006 (HMM): cysteine desulfurase IscS | |
| tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase | MnmA | YES | TIGR00420 (HMM): tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase | |
| MnmC, C-term model | MnmC_C | NO | TIGR03197 (HMM): tRNA U-34 5-methylaminomethyl-2-thiouridine biosynthesis protein MnmC, C-terminal domain | |
| U34 modification protein MnmE | MnmE | YES | TIGR00450 (HMM): tRNA modification GTPase TrmE |
Parent Properties
| Accession | Name |
|---|---|
| GenProp0197 | protein biosynthesis |
| GenProp0819 | RNA metabolism |
Sibling Properties
| Accession | Name |
|---|---|
| GenProp0016 | selenocysteine system |
| GenProp0312 | pyrrolysine |
| GenProp0132 | transcription termination - antitermination Nus factors |
| GenProp0148 | release factor 2 programmed frameshift |
| GenProp0174 | ribosome, bacterial, large subunit |
| GenProp0175 | ribosome, bacterial, small subunit |
| GenProp0188 | GatABC aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase complex |
| GenProp0189 | tRNA-Gln direct aminoacylation |
| GenProp0211 | tmRNA trans-translation system |
| GenProp0258 | tRNA aminoacylation |
| GenProp0259 | tRNA-Asn direct aminoacylation |
| GenProp0304 | cysteine biosynthesis, tRNA-dependent |
| GenProp0634 | Sigma-54 (RpoN) systems |
| GenProp0692 | selenouridine-containing tRNA |
| GenProp0740 | translation initiation, bacterial |
| GenProp0741 | translation elongation, bacterial |
| GenProp0746 | translation termination, bacterial |
| GenProp0812 | rho-dependent termination |
| GenProp0262 | RNA polymerase, bacterial |
| GenProp0482 | 6S RNA (eubacterial RNA polymerase regulator) |
| GenProp0677 | queuosine (Q-tRNA) biosynthesis from preQ0 |
| GenProp0898 | RNA ligase/unknown protein pair |
| GenProp0948 | RNA repair, Hen1/Pnkp system |
| GenProp1060 | tRNA N6-threonylcarbamoyladenosine modification |
| GenProp1077 | tRNA(Pro) cmo5UGG modification |
| GenProp1082 | 16S rRNA C1402 m(4)Cm modification |