Genome Property Definition Page
| Accession | GenProp0746 |
| Name | translation termination, bacterial |
| Type | SYSTEM |
| Description | This Genome Property describes the basic set of bacterial transcription termination factors. Release factor 1 (RF-1, PrfA) should be both universal among bacteria and univerally detected, as should release factor 3 (RF-3). Release factor 2 is a special case. It is truly absent in the Mycoplasmatales, including Mycoplasma genitalium. Its absence means TGA is not recognized as a stop coodon. It codes for Trp instead. However, release factor 2 in most bacteria is encoded by a gene with a programmed frameshift about 25 amino acids from the N-terminus. It may be annotated incorrectly as a truncated or disrupted gene and therefore not detected by its HMM, TIGR00020. A fourth protein included in this genome property is the ribosome recycling factor, which also partipates in processes at the conclusion of bacterial protein translation. This property does not include PrfH, part of a specialized system present only in some bacteria, as it is intended for essentially univeral bacterial termination factors; see instead GenProp0665. |
| JCVI Role | Translation factors |
| Parent Property | GenProp0197: protein biosynthesis |
Components
| Step Name | Step Num | Required | Evidence (Method) | Evidence Go Terms |
|---|---|---|---|---|
| release factor methylase | hemK | YES | TIGR03534 (HMM): protein-(glutamine-N5) methyltransferase, release factor-specific TIGR00536 (HMM-CLUST): methyltransferase, HemK family | |
| peptide chain release factor 1 | prfA | YES | TIGR00019 (HMM): peptide chain release factor 1 | |
| peptide chain release factor 2 | prfB | YES | TIGR00020 (HMM): peptide chain release factor 2 | |
| peptide chain release factor 3 | prfC | YES | TIGR00503 (HMM): peptide chain release factor 3 | |
| ribosome recycling factor | recyc | YES | TIGR00496 (HMM): ribosome recycling factor |
Parent Properties
| Accession | Name |
|---|---|
| GenProp0197 | protein biosynthesis |
Sibling Properties
| Accession | Name |
|---|---|
| GenProp0016 | selenocysteine system |
| GenProp0312 | pyrrolysine |
| GenProp0132 | transcription termination - antitermination Nus factors |
| GenProp0148 | release factor 2 programmed frameshift |
| GenProp0174 | ribosome, bacterial, large subunit |
| GenProp0175 | ribosome, bacterial, small subunit |
| GenProp0188 | GatABC aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase complex |
| GenProp0189 | tRNA-Gln direct aminoacylation |
| GenProp0211 | tmRNA trans-translation system |
| GenProp0258 | tRNA aminoacylation |
| GenProp0259 | tRNA-Asn direct aminoacylation |
| GenProp0304 | cysteine biosynthesis, tRNA-dependent |
| GenProp0634 | Sigma-54 (RpoN) systems |
| GenProp0692 | selenouridine-containing tRNA |
| GenProp0704 | tRNA U34 carboxymethylaminomethyl modification |
| GenProp0740 | translation initiation, bacterial |
| GenProp0741 | translation elongation, bacterial |
| GenProp0812 | rho-dependent termination |