| Description | This property describes a regulon present in E. coli and a number of other species induced by various stresses including osmotic shock, ethanol, heat, and expression of various secretins, as occurs with infection by certain filamentous phage. A common thread to these stressors may be compromise of the inner membrane and decrease of the protonmotive force. Most proteins of the regulon occur in a single operon, but at least one member, pspG, is located elsewhere in most genomes. The signature genes of the the phage shock regulon are the sigma-54-dependent positive regulator PspF, PspA which binds to and inhibits PspF, and PspB and PspC which act together as both regulatory and effector proteins of the phage shock regulon. PspG occurs in most but not all phage shock-positive genomes, while PspD and PspE are found only in a minority of phage shock operons. |
| Literature References | [ 1 ]Brissette JL, Weiner L, Ripmaster TL, Model P Characterization and sequence of the Escherichia coli stress-induced psp operon. J Mol Biol. 1991 Jul 5;220(1):35-48. PMID 1712397
[ 2 ]Jovanovic G, Weiner L, Model P Identification, nucleotide sequence, and characterization of PspF, the transcriptional activator of the Escherichia coli stress-induced psp operon. J Bacteriol. 1996 Apr;178(7):1936-45. PMID 8606168
[ 3 ]Lloyd LJ, Jones SE, Jovanovic G, Gyaneshwar P, Rolfe MD, Thompson A, Hinton JC, Buck M Identification of a new member of the phage shock protein response in Escherichia coli, the phage shock protein G (PspG). J Biol Chem. 2004 Dec 31;279(53):55707-14. Epub 2004 Oct 13. PMID 15485810
[ 4 ]Jovanovic G, Lloyd LJ, Stumpf MP, Mayhew AJ, Buck M Induction and function of the phage-shock-protein (Psp) extracytoplasmic stress response in Escherichia coli. J Biol Chem. 2006 May 17 PMID 16709570
[ 5 ]Trotochaud AE, Wassarman KM 6S RNA regulation of pspF transcription leads to altered cell survival at high pH. J Bacteriol. 2006 Jun;188(11):3936-43. PMID 16707685
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