Genome Property Definition Page

Nameaccessory Sec system for serine-rich glycoprotein transport
DescriptionA number of Gram-positive pathogens express serine-rich glycoproteins such as the platelet-binding glycoprotein GspB of Streptococcus gordonii. At least 5 core proteins contribute to the export of these proteins, including SecY2 and SecA2, homologs respectively of the SecY and SecA proteins of the Sec system. Additional proteins are required for glycosylation rather than export.
JCVI RoleProtein and peptide secretion and trafficking
Parent PropertyGenProp0179: protein transport
Literature References
[ 1 ] Takamatsu D, Bensing BA, Sullam PM   Two additional components of the accessory sec system mediating export of the Streptococcus gordonii platelet-binding protein GspB.   J Bacteriol. 2005 Jun;187(11):3878-83.  PMID 15901716
[ 2 ] Siboo IR, Chaffin DO, Rubens CE, Sullam PM   Characterization of the accessory Sec system of Staphylococcus aureus.   J Bacteriol. 2008 Sep;190(18):6188-96.  PMID 18621893
Gene Ontology TermGO:0034436: glycoprotein transport (biological_process)

Step NameStep NumRequiredEvidence (Method)Evidence Go Terms
serine-rich glycoproteinS_richNOTIGR03715 (HMM-CLUST): KxYKxGKxW signal peptide
TIGR04224 (HMM): serine-rich repeat adhesion glycoprotein
accessory Sec system translocase SecA2SecA2YESTIGR03714 (HMM): accessory Sec system translocase SecA2GO:0034436: glycoprotein transport
accessory Sec system translocase SecY2SecY2YESTIGR02920 (HMM): accessory Sec system translocase SecY2GO:0034436: glycoprotein transport
accessory Sec system protein Asp1accSec1YESTIGR03713 (HMM): accessory Sec system protein Asp1GO:0034436: glycoprotein transport
accessory Sec system protein Asp2accSec2YESTIGR03712 (HMM): accessory Sec system protein Asp2GO:0034436: glycoprotein transport
accessory Sec system protein Asp3accSec3YESTIGR03711 (HMM): accessory Sec system protein Asp3GO:0034436: glycoprotein transport
accessory Sec system protein Asp4accSec4NO2379 (RULE_BASE)
GO:0034436: glycoprotein transport
accessory Sec system protein Asp5accSec5NO2378 (RULE_BASE)
GO:0034436: glycoprotein transport
accessory Sec system glycosyltransferase GtfAgtfANOTIGR02918 (HMM): accessory Sec system glycosylation protein GtfA
accessory Sec system glycosyltransferase GtfBgtfBNOTIGR02919 (HMM): accessory Sec system glycosyltransferase GtfB

Parent Properties
GenProp0179protein transport

Sibling Properties
GenProp0052type III secretion
GenProp0053type II secretion
GenProp0054type IV secretion
GenProp0059type I secretion
GenProp0127Tat (Sec-independent) protein export
GenProp0205signal recognition system, bacterial
GenProp0207lipoprotein localization system lolABCDE
GenProp0209Sec system preprotein translocase
GenProp0295prokaryotic N-terminal cleavage/methylation, type IV pilin-like
GenProp0326protein sorting system, PEP-CTERM/exosortase (generic)
GenProp0626protein sorting system, sortase type, LPXTG/SrtA class
GenProp0664protein sorting system, sortase type, SrtB class
GenProp0669protein sorting system, putative, exosortase G class
GenProp0735type VI secretion
GenProp0778protein sorting system, GlyGly-CTERM/rhombosortase
GenProp0845protein sorting system, KxYKxGKxW class
GenProp0859protein sorting system, proteobacterial dedicated sortase type
GenProp0904type VII secretion, Actinobacteria form
GenProp0905type VII secretion, Firmicutes form
GenProp0928OMP chaperone system: SurA-Skp-DegP
GenProp0957protein sorting system, SipW class
GenProp0978protein sorting system, PGF-CTERM/archaeosortase A
GenProp0979protein sorting system, PEF-CTERM/archaeosortase C
GenProp0980protein sorting system, putative, exosortase F class
GenProp0983protein sorting system, VPXXXP-CTERM/archaeosortase B
GenProp0985protein sorting system, VPDSG-CTERM/exosortase C
GenProp0986protein sorting system, VPLPA-CTERM/exosortase D
GenProp0987protein sorting system, cyano-PEP-CTERM class
GenProp0989protein sorting system, VPEID-CTERM/exosortase E
GenProp0993protein sorting system, PIP-CTERM/archaeosortase D
GenProp0996protein sorting system, IPTLxxWG-CTERM/exosortase H
GenProp0999Por secretion system
GenProp1005protein sorting system, putative, exosortase J class
GenProp1054protein sorting system, MSEP-CTERM/exosortase K
GenProp1055protein sorting system, PEFG-CTERM/thaumarchaeosortase
GenProp1074type V secretion
GenProp1087protein sorting system, vault protein/exosortase N
GenProp1102protein sorting system, CGP-CTERM/unknown of Thermococcaceae
GenProp1103protein sorting system, Synergist-CTERM/unknown of Synergistetes