Genome Property Definition Page

Namelipoprotein localization system lolABCDE
DescriptionBacterial lipoproteins have a modified amino terminal Cys residue with a covalently attached lipid moiety that serves as a membrane anchor. The lol system is responsible for moving lipoproteins from the periplasmic side of the inner membrane to the periplasmic side of the outer membrane. LolD is homologous to the ATP-binding cassette (ABC) transport family. LolC and LolE are homologous to each other (in species that have both rather than just one) and have several membrane-spanning segments, much like ABC transport permeases. However, the LolCDE complex differs from other ABC transporters in that is does not move a substrate across a membrane. Instead, it detaches lipoproteins from the inner membrane. LolA and LolB act to chaperone lipoproteins, including LolB itself, to the outer membrane. This system is less broadly distributed than the lgt/lsp/lnt system for lipoprotein N-terminal modification.
JCVI RoleProtein and peptide secretion and trafficking
Parent PropertyGenProp0179: protein transport
Literature References
[ 1 ]Narita S, Kanamaru K, Matsuyama S, Tokuda H.  A mutation in the membrane subunit of an ABC transporter LolCDE complex causing outer membrane localization of lipoproteins against their inner membrane-specific signals.  Mol Microbiol. 2003 Jul;49(1):167-77.  PMID 12823819
[ 2 ]Tanaka K, Matsuyama SI, Tokuda H.  Deletion of lolB, encoding an outer membrane lipoprotein, is lethal for Escherichia coli and causes accumulation of lipoprotein localization intermediates in the periplasm.  J Bacteriol. 2001 Nov;183(22):6538-42.  PMID 11673422
Gene Ontology TermGO:0006886: intracellular protein transport (biological_process)

Step NameStep NumRequiredEvidence (Method)Evidence Go Terms
lipoprotein carrier LolALolAYESTIGR00547 (HMM): outer membrane lipoprotein carrier protein LolAGO:0006886: intracellular protein transport
outer membrane LP LolBLolBYESTIGR00548 (HMM): outer membrane lipoprotein LolBGO:0006886: intracellular protein transport
lipoprotein export, LolC and LolE familyLolCEYESTIGR02212 (HMM): lipoprotein releasing system, transmembrane protein, LolC/E familyGO:0006886: intracellular protein transport
transporter ATP-binding subunit LolDLolDYESTIGR02211 (HMM): lipoprotein releasing system, ATP-binding proteinGO:0006886: intracellular protein transport

Parent Properties
GenProp0179protein transport

Sibling Properties
GenProp0052type III secretion
GenProp0053type II secretion
GenProp0054type IV secretion
GenProp0059type I secretion
GenProp0127Tat (Sec-independent) protein export
GenProp0205signal recognition system, bacterial
GenProp0209Sec system preprotein translocase
GenProp0295prokaryotic N-terminal cleavage/methylation, type IV pilin-like
GenProp0326protein sorting system, PEP-CTERM/exosortase (generic)
GenProp0626protein sorting system, sortase type, LPXTG/SrtA class
GenProp0664protein sorting system, sortase type, SrtB class
GenProp0669protein sorting system, putative, exosortase G class
GenProp0735type VI secretion
GenProp0778protein sorting system, GlyGly-CTERM/rhombosortase
GenProp0844accessory Sec system for serine-rich glycoprotein transport
GenProp0845protein sorting system, KxYKxGKxW class
GenProp0859protein sorting system, proteobacterial dedicated sortase type
GenProp0904type VII secretion, Actinobacteria form
GenProp0905type VII secretion, Firmicutes form
GenProp0928OMP chaperone system: SurA-Skp-DegP
GenProp0957protein sorting system, SipW class
GenProp0978protein sorting system, PGF-CTERM/archaeosortase A
GenProp0979protein sorting system, PEF-CTERM/archaeosortase C
GenProp0980protein sorting system, putative, exosortase F class
GenProp0983protein sorting system, VPXXXP-CTERM/archaeosortase B
GenProp0985protein sorting system, VPDSG-CTERM/exosortase C
GenProp0986protein sorting system, VPLPA-CTERM/exosortase D
GenProp0987protein sorting system, cyano-PEP-CTERM class
GenProp0989protein sorting system, VPEID-CTERM/exosortase E
GenProp0993protein sorting system, PIP-CTERM/archaeosortase D
GenProp0996protein sorting system, IPTLxxWG-CTERM/exosortase H
GenProp0999Por secretion system
GenProp1005protein sorting system, putative, exosortase J class
GenProp1054protein sorting system, MSEP-CTERM/exosortase K
GenProp1055protein sorting system, PEFG-CTERM/thaumarchaeosortase
GenProp1074type V secretion
GenProp1087protein sorting system, vault protein/exosortase N
GenProp1102protein sorting system, CGP-CTERM/unknown of Thermococcaceae
GenProp1103protein sorting system, Synergist-CTERM/unknown of Synergistetes