| Accession | GenProp0207 |
| Name | lipoprotein localization system lolABCDE |
| Type | SYSTEM |
| Description | Bacterial lipoproteins have a modified amino terminal Cys residue with a covalently attached lipid moiety that serves as a membrane anchor. The lol system is responsible for moving lipoproteins from the periplasmic side of the inner membrane to the periplasmic side of the outer membrane. LolD is homologous to the ATP-binding cassette (ABC) transport family. LolC and LolE are homologous to each other (in species that have both rather than just one) and have several membrane-spanning segments, much like ABC transport permeases. However, the LolCDE complex differs from other ABC transporters in that is does not move a substrate across a membrane. Instead, it detaches lipoproteins from the inner membrane. LolA and LolB act to chaperone lipoproteins, including LolB itself, to the outer membrane. This system is less broadly distributed than the lgt/lsp/lnt system for lipoprotein N-terminal modification. |
| JCVI Role | Protein and peptide secretion and trafficking |
| Parent Property | GenProp0179: protein transport
|
| Literature References | [ 1 ]Narita S, Kanamaru K, Matsuyama S, Tokuda H. A mutation in the membrane subunit of an ABC transporter LolCDE complex causing outer membrane localization of lipoproteins against their inner membrane-specific signals. Mol Microbiol. 2003 Jul;49(1):167-77. PMID 12823819
[ 2 ]Tanaka K, Matsuyama SI, Tokuda H. Deletion of lolB, encoding an outer membrane lipoprotein, is lethal for Escherichia coli and causes accumulation of lipoprotein localization intermediates in the periplasm. J Bacteriol. 2001 Nov;183(22):6538-42. PMID 11673422
|
|
| Gene Ontology Term | GO:0006886: intracellular protein transport (biological_process)
|
| Step Name | Step Num | Required | Evidence (Method) | Evidence Go Terms |
|---|
| lipoprotein carrier LolA | LolA | YES | TIGR00547 (HMM): outer membrane lipoprotein carrier protein LolA | GO:0006886: intracellular protein transport
|
| outer membrane LP LolB | LolB | YES | TIGR00548 (HMM): outer membrane lipoprotein LolB | GO:0006886: intracellular protein transport
|
| lipoprotein export, LolC and LolE family | LolCE | YES | TIGR02212 (HMM): lipoprotein releasing system, transmembrane protein, LolC/E family | GO:0006886: intracellular protein transport
|
| transporter ATP-binding subunit LolD | LolD | YES | TIGR02211 (HMM): lipoprotein releasing system, ATP-binding protein | GO:0006886: intracellular protein transport
|
| Accession | Name |
|---|
| GenProp0052 | type III secretion |
| GenProp0053 | type II secretion |
| GenProp0054 | type IV secretion |
| GenProp0059 | type I secretion |
| GenProp0127 | Tat (Sec-independent) protein export |
| GenProp0205 | signal recognition system, bacterial |
| GenProp0209 | Sec system preprotein translocase |
| GenProp0295 | prokaryotic N-terminal cleavage/methylation, type IV pilin-like |
| GenProp0326 | protein sorting system, PEP-CTERM/exosortase (generic) |
| GenProp0626 | protein sorting system, sortase type, LPXTG/SrtA class |
| GenProp0664 | protein sorting system, sortase type, SrtB class |
| GenProp0669 | protein sorting system, putative, exosortase G class |
| GenProp0735 | type VI secretion |
| GenProp0778 | protein sorting system, GlyGly-CTERM/rhombosortase |
| GenProp0844 | accessory Sec system for serine-rich glycoprotein transport |
| GenProp0845 | protein sorting system, KxYKxGKxW class |
| GenProp0847 | exosporium |
| GenProp0859 | protein sorting system, proteobacterial dedicated sortase type |
| GenProp0904 | type VII secretion, Actinobacteria form |
| GenProp0905 | type VII secretion, Firmicutes form |
| GenProp0928 | OMP chaperone system: SurA-Skp-DegP |
| GenProp0957 | protein sorting system, SipW class |
| GenProp0978 | protein sorting system, PGF-CTERM/archaeosortase A |
| GenProp0979 | protein sorting system, PEF-CTERM/archaeosortase C |
| GenProp0980 | protein sorting system, putative, exosortase F class |
| GenProp0983 | protein sorting system, VPXXXP-CTERM/archaeosortase B |
| GenProp0985 | protein sorting system, VPDSG-CTERM/exosortase C |
| GenProp0986 | protein sorting system, VPLPA-CTERM/exosortase D |
| GenProp0987 | protein sorting system, cyano-PEP-CTERM class |
| GenProp0989 | protein sorting system, VPEID-CTERM/exosortase E |
| GenProp0993 | protein sorting system, PIP-CTERM/archaeosortase D |
| GenProp0996 | protein sorting system, IPTLxxWG-CTERM/exosortase H |
| GenProp0999 | Por secretion system |
| GenProp1005 | protein sorting system, putative, exosortase J class |
| GenProp1054 | protein sorting system, MSEP-CTERM/exosortase K |
| GenProp1055 | protein sorting system, PEFG-CTERM/thaumarchaeosortase |
| GenProp1074 | type V secretion |
| GenProp1087 | protein sorting system, vault protein/exosortase N |
| GenProp1102 | protein sorting system, CGP-CTERM/unknown of Thermococcaceae |
| GenProp1103 | protein sorting system, Synergist-CTERM/unknown of Synergistetes |
