Genome Property Definition Page

Nameprotein sorting system, GlyGly-CTERM/rhombosortase
DescriptionThe GlyGly-CTERM domain, previously called the gammaproteobacterial enzyme C-terminal transmembrane domain or rhombotail, appears to be a protein sorting signal analogous to LPXTG and PEP-CTERM. Every genome that encodes a set of GlyGly-CTERM proteins also encodes a rhomboid family enzyme, designated rhombosortase, in a many-to-one relationship. Rhomboid proteases are serine proteases with the active site Ser within the membrane, and they are capable of cleaving hydrophobic transmembrane segments. In general, genomes that encode GlyGly-CTERM proteins and rhombosortase also encode a type 2 secretion system (T2SS). Several GlyGly-CTERM proteins have been shown to undergo T2SS-mediated secretion.
Parent PropertyGenProp0179: protein transport
Literature References
[ 1 ]Haft DH, Varghese N  GlyGly-CTERM and rhombosortase: a C-terminal protein processing signal in a many-to-one pairing with a rhomboid family intramembrane serine protease.  PLoS One. 2011;6(12):e28886. doi: 10.1371/journal.pone.0028886.  PMID 22194940
[ 2 ]Sikora AE, Zielke RA, Lawrence DA, Andrews PC, Sandkvist M  Proteomic analysis of the Vibrio cholerae type II secretome reveals new proteins, including three related serine proteases.  J Biol Chem. 2011 May 13;286(19):16555-66. doi: 10.1074/jbc.M110.211078.  PMID 21385872

Step NameStep NumRequiredEvidence (Method)Evidence Go Terms
GlyGly-CTERM sorting domainGGctermYESTIGR03501 (HMM): GlyGly-CTERM domain
TIGR03867 (HMM): MprA protease C-terminal rhombosortase-interaction domain
rhombosortaserhomsortYESTIGR03902 (HMM): rhombosortase

Parent Properties
GenProp0179protein transport

Sibling Properties
GenProp0052type III secretion
GenProp0053type II secretion
GenProp0054type IV secretion
GenProp0059type I secretion
GenProp0127Tat (Sec-independent) protein export
GenProp0205signal recognition system, bacterial
GenProp0207lipoprotein localization system lolABCDE
GenProp0209Sec system preprotein translocase
GenProp0295prokaryotic N-terminal cleavage/methylation, type IV pilin-like
GenProp0326protein sorting system, PEP-CTERM/exosortase (generic)
GenProp0626protein sorting system, sortase type, LPXTG/SrtA class
GenProp0664protein sorting system, sortase type, SrtB class
GenProp0669protein sorting system, putative, exosortase G class
GenProp0735type VI secretion
GenProp0844accessory Sec system for serine-rich glycoprotein transport
GenProp0845protein sorting system, KxYKxGKxW class
GenProp0859protein sorting system, proteobacterial dedicated sortase type
GenProp0904type VII secretion, Actinobacteria form
GenProp0905type VII secretion, Firmicutes form
GenProp0928OMP chaperone system: SurA-Skp-DegP
GenProp0957protein sorting system, SipW class
GenProp0978protein sorting system, PGF-CTERM/archaeosortase A
GenProp0979protein sorting system, PEF-CTERM/archaeosortase C
GenProp0980protein sorting system, putative, exosortase F class
GenProp0983protein sorting system, VPXXXP-CTERM/archaeosortase B
GenProp0985protein sorting system, VPDSG-CTERM/exosortase C
GenProp0986protein sorting system, VPLPA-CTERM/exosortase D
GenProp0987protein sorting system, cyano-PEP-CTERM class
GenProp0989protein sorting system, VPEID-CTERM/exosortase E
GenProp0993protein sorting system, PIP-CTERM/archaeosortase D
GenProp0996protein sorting system, IPTLxxWG-CTERM/exosortase H
GenProp0999Por secretion system
GenProp1005protein sorting system, putative, exosortase J class
GenProp1054protein sorting system, MSEP-CTERM/exosortase K
GenProp1055protein sorting system, PEFG-CTERM/thaumarchaeosortase
GenProp1074type V secretion
GenProp1087protein sorting system, vault protein/exosortase N
GenProp1102protein sorting system, CGP-CTERM/unknown of Thermococcaceae
GenProp1103protein sorting system, Synergist-CTERM/unknown of Synergistetes