Genome Property Definition Page

Nametype VII secretion, Firmicutes form
DescriptionThis Genome Property describes the Firmicutes secretion system related to the well-described type VII secretion system of Actinobacteria such as Mycobacterium tuberculosis. In both systems, members of the WXG100 (PF06013) are targets, and a homolog of EccC (models TIGR03924 and TIGR03925) is present. Otherwise, differences appear to be profound.
JCVI RoleProtein and peptide secretion and trafficking
Parent PropertyGenProp0179: protein transport
Literature References
[ 1 ]Garufi G, Butler E, Missiakas D  ESAT-6-like protein secretion in Bacillus anthracis.  J Bacteriol. 2008 Nov;190(21):7004-11. Epub 2008 Aug 22.  PMID 18723613
[ 2 ]Burts ML, DeDent AC, Missiakas DM  EsaC substrate for the ESAT-6 secretion pathway and its role in persistent infections of Staphylococcus aureus.  Mol Microbiol. 2008 Aug;69(3):736-46. Epub 2008 Jun 28.  PMID 18554323

Step NameStep NumRequiredEvidence (Method)Evidence Go Terms
type VII secretion protein EsaAT7_EsaANOTIGR03929 (HMM): type VII secretion protein EsaA
type VII secretion protein EssAT7_EssAYESTIGR03927 (HMM): type VII secretion protein EssA
type VII secretion protein EssCT7_EssCYESTIGR03928 (HMM): type VII secretion protein EssC
type VII secretion target, WXG100 familyT7_WxGYESPF06013 (HMM-CLUST): WXG motif protein
TIGR03930 (HMM-CLUST): WXG100 family type VII secretion target
TIGR04197 (HMM): type VII secretion effector, TIGR04197 family
type VII secretion protein EsaBT7_esaBYESPF08817 (HMM): type VII secretion system protein YukD
type VII secretion protein EssBT7_essBYESTIGR03926 (HMM): type VII secretion protein EssB

Parent Properties
GenProp0179protein transport

Sibling Properties
GenProp0052type III secretion
GenProp0053type II secretion
GenProp0054type IV secretion
GenProp0059type I secretion
GenProp0127Tat (Sec-independent) protein export
GenProp0205signal recognition system, bacterial
GenProp0207lipoprotein localization system lolABCDE
GenProp0209Sec system preprotein translocase
GenProp0295prokaryotic N-terminal cleavage/methylation, type IV pilin-like
GenProp0326protein sorting system, PEP-CTERM/exosortase (generic)
GenProp0626protein sorting system, sortase type, LPXTG/SrtA class
GenProp0664protein sorting system, sortase type, SrtB class
GenProp0669protein sorting system, putative, exosortase G class
GenProp0735type VI secretion
GenProp0778protein sorting system, GlyGly-CTERM/rhombosortase
GenProp0844accessory Sec system for serine-rich glycoprotein transport
GenProp0845protein sorting system, KxYKxGKxW class
GenProp0859protein sorting system, proteobacterial dedicated sortase type
GenProp0904type VII secretion, Actinobacteria form
GenProp0928OMP chaperone system: SurA-Skp-DegP
GenProp0957protein sorting system, SipW class
GenProp0978protein sorting system, PGF-CTERM/archaeosortase A
GenProp0979protein sorting system, PEF-CTERM/archaeosortase C
GenProp0980protein sorting system, putative, exosortase F class
GenProp0983protein sorting system, VPXXXP-CTERM/archaeosortase B
GenProp0985protein sorting system, VPDSG-CTERM/exosortase C
GenProp0986protein sorting system, VPLPA-CTERM/exosortase D
GenProp0987protein sorting system, cyano-PEP-CTERM class
GenProp0989protein sorting system, VPEID-CTERM/exosortase E
GenProp0993protein sorting system, PIP-CTERM/archaeosortase D
GenProp0996protein sorting system, IPTLxxWG-CTERM/exosortase H
GenProp0999Por secretion system
GenProp1005protein sorting system, putative, exosortase J class
GenProp1054protein sorting system, MSEP-CTERM/exosortase K
GenProp1055protein sorting system, PEFG-CTERM/thaumarchaeosortase
GenProp1074type V secretion
GenProp1087protein sorting system, vault protein/exosortase N
GenProp1102protein sorting system, CGP-CTERM/unknown of Thermococcaceae
GenProp1103protein sorting system, Synergist-CTERM/unknown of Synergistetes