Genome Property Definition Page
| Accession | GenProp0626 |
| Name | protein sorting system, sortase type, LPXTG/SrtA class |
| Type | SYSTEM |
| Description | This property describes the common subtype of the sortase system for targeting cell wall proteins in the Firmicutes by recognition of the LPXTG C-terminal motif. The presence of one or more sortases and their target sequences should be universal in Gram-positive organisms with cell walls. Sortase is a transpeptidase; sortases belonging to this Genome Property resemble SrtA, and the sorting signal generally resembles LPXTG. Several SrtA paralogs can be found in some genomes, as well as the substantially different SrtB and other families of sortase and their cognate sequences. |
| JCVI Role | Protein and peptide secretion and trafficking |
| Parent Property | GenProp0069: cell surface component GenProp0179: protein transport |
Components
| Step Name | Step Num | Required | Evidence (Method) | Evidence Go Terms |
|---|---|---|---|---|
| LPXTG-like C-terminal region | LPXTG | YES | TIGR01167 (HMM): LPXTG cell wall anchor domain | |
| sortase (transpeptidase) | sortase | YES | TIGR01076 (HMM): sortase |
Parent Properties
| Accession | Name |
|---|---|
| GenProp0069 | cell surface component |
| GenProp0179 | protein transport |
Sibling Properties
| Accession | Name |
|---|---|
| GenProp0007 | flagella |
| GenProp0012 | outer membrane |
| GenProp0022 | S-layer |
| GenProp0056 | type IV pilus |
| GenProp0062 | capsule |
| GenProp0158 | peptidoglycan(murein) biosynthesis |
| GenProp0297 | lipopolysaccharide biosynthesis |
| GenProp0326 | protein sorting system, PEP-CTERM/exosortase (generic) |
| GenProp0664 | protein sorting system, sortase type, SrtB class |
| GenProp0725 | outer membrane protein assembly complex |
| GenProp0811 | S-layer homology domain-mediated cell wall binding |
| GenProp0847 | exosporium |
| GenProp0857 | anchored repeat-class ABC transporter, P. acnes type |
| GenProp0859 | protein sorting system, proteobacterial dedicated sortase type |
| GenProp0052 | type III secretion |
| GenProp0053 | type II secretion |
| GenProp0054 | type IV secretion |
| GenProp0059 | type I secretion |
| GenProp0127 | Tat (Sec-independent) protein export |
| GenProp0205 | signal recognition system, bacterial |
| GenProp0207 | lipoprotein localization system lolABCDE |
| GenProp0209 | Sec system preprotein translocase |
| GenProp0295 | prokaryotic N-terminal cleavage/methylation, type IV pilin-like |
| GenProp0669 | protein sorting system, putative, exosortase G class |
| GenProp0735 | type VI secretion |
| GenProp0778 | protein sorting system, GlyGly-CTERM/rhombosortase |
| GenProp0844 | accessory Sec system for serine-rich glycoprotein transport |
| GenProp0845 | protein sorting system, KxYKxGKxW class |
| GenProp0904 | type VII secretion, Actinobacteria form |
| GenProp0905 | type VII secretion, Firmicutes form |
| GenProp0928 | OMP chaperone system: SurA-Skp-DegP |
| GenProp0957 | protein sorting system, SipW class |
| GenProp0978 | protein sorting system, PGF-CTERM/archaeosortase A |
| GenProp0979 | protein sorting system, PEF-CTERM/archaeosortase C |
| GenProp0980 | protein sorting system, putative, exosortase F class |
| GenProp0983 | protein sorting system, VPXXXP-CTERM/archaeosortase B |
| GenProp0985 | protein sorting system, VPDSG-CTERM/exosortase C |
| GenProp0986 | protein sorting system, VPLPA-CTERM/exosortase D |
| GenProp0987 | protein sorting system, cyano-PEP-CTERM class |
| GenProp0989 | protein sorting system, VPEID-CTERM/exosortase E |
| GenProp0993 | protein sorting system, PIP-CTERM/archaeosortase D |
| GenProp0996 | protein sorting system, IPTLxxWG-CTERM/exosortase H |
| GenProp0999 | Por secretion system |
| GenProp1005 | protein sorting system, putative, exosortase J class |
| GenProp1054 | protein sorting system, MSEP-CTERM/exosortase K |
| GenProp1055 | protein sorting system, PEFG-CTERM/thaumarchaeosortase |
| GenProp1074 | type V secretion |
| GenProp1087 | protein sorting system, vault protein/exosortase N |
| GenProp1102 | protein sorting system, CGP-CTERM/unknown of Thermococcaceae |
| GenProp1103 | protein sorting system, Synergist-CTERM/unknown of Synergistetes |