Genome Property Definition Page
Accession | GenProp0052 | |
Name | type III secretion | |
Type | SYSTEM | |
Description | Type III secretion systems are found in a number of pathogenenic gram-negative bacteria. These systems consist of approximately twenty-five translocation proteins, as well as those proteins that are transported either across the bacterial inner and outer membrane, into the medium, or further across a eukaryotic target cell membrane. Substrates for type III secretion are not cleaved during transport, although the signal for transport appears to lie near the N-terminus (or in the RNA); chaperones act as well for some substrates and may be a second signal. Proteins delivered to the target cell cytosol and active in pathogenesis are termed effectors. Type III secretion systems resemble some of the flagellar export apparatus. In some cases, a type III pilus is observed and required for effector delivery. Gene nomeclature transposes across genomes: ysc in Yersinia, bsc in Bordetella, esc in enteropathogenic E. coli, hrc in plant pathogens, etc., so that Ysc, EscD, HrcD, etc. are homologous and functionally analogous [1,2]. | |
Parent Property | GenProp0074: virulence GenProp0179: protein transport | |
Literature References |
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Web References | KEGG: Type III secretion system | |
Gene Ontology Term | GO:0030254: protein secretion by the type III secretion system (biological_process) |
Components
Step Name | Step Num | Required | Evidence (Method) | Evidence Go Terms |
---|---|---|---|---|
HpaP | HpaP | NO | TIGR02557 (HMM): type III secretion protein HpaP | GO:0030254: protein secretion by the type III secretion system |
HrpB1/HrpK | HrpB1 | NO | TIGR02561 (HMM): type III secretion protein HrpB1/HrpK | GO:0030254: protein secretion by the type III secretion system |
HrpB2 | HrpB2 | NO | TIGR02558 (HMM): type III secretion protein HrpB2 | GO:0030254: protein secretion by the type III secretion system |
HrpB4 | HrpB4 | NO | TIGR02560 (HMM): type III secretion protein HrpB4 | GO:0030254: protein secretion by the type III secretion system |
HrpB7 | HrpB7 | NO | TIGR02559 (HMM): type III secretion protein HrpB7 | GO:0030254: protein secretion by the type III secretion system |
LcrE/YopN/InvE/MxiC | LcrE | NO | TIGR02568 (HMM): type III secretion regulator YopN/LcrE/InvE/MxiC | GO:0030254: protein secretion by the type III secretion system |
LcrG/PcrG | LcrG | NO | TIGR02573 (HMM): type III secretion protein LcrG | GO:0030254: protein secretion by the type III secretion system |
LcrH/SycD/SpaT | LcrH | NO | TIGR02552 (HMM): type III secretion low calcium response chaperone LcrH/SycD | GO:0030254: protein secretion by the type III secretion system |
regulatory component LcrR | LcrR | NO | TIGR02572 (HMM): type III secretion system regulator LcrR | GO:0030254: protein secretion by the type III secretion system |
OrgA/MxiK | OrgA | NO | TIGR02555 (HMM): type III secretion apparatus protein OrgA/MxiK | GO:0030254: protein secretion by the type III secretion system |
PrgH | PrgH | NO | TIGR02554 (HMM): type III secretion apparatus protein PrgH/EprH | GO:0030254: protein secretion by the type III secretion system |
SpaK/InvB/YsaK | SpaK | NO | PF03519 (HMM): invasion protein B family | GO:0030254: protein secretion by the type III secretion system |
SseC/YopB/EspD | SseC | NO | PF04888 (HMM): secretion system effector C, SseC-like family | GO:0030254: protein secretion by the type III secretion system |
type III secretion chaperone SycH | SycH | NO | PF05932 (HMM): type III secretion chaperone, CesT family | GO:0030254: protein secretion by the type III secretion system |
type III secretion chaperone SycN | SycN | NO | TIGR02503 (HMM): type III secretion chaperone SycN | GO:0030254: protein secretion by the type III secretion system |
type III secretion effector delivery regulator, TyeA family | TyeA | YES | TIGR02511 (HMM): type III secretion effector delivery regulator, TyeA family | GO:0030254: protein secretion by the type III secretion system |
YopD | YopD | NO | PF05844 (HMM): YopD protein | GO:0030254: protein secretion by the type III secretion system |
needle length determinant | ndl_len | NO | TIGR02514 (HMM): type III secretion system needle length determinant | GO:0030254: protein secretion by the type III secretion system |
type III secretion system needle protein | needle | YES | TIGR02105 (HMM): type III secretion apparatus needle protein | GO:0030254: protein secretion by the type III secretion system |
in operon: flanked by, co-oriented and tight with evidence | operon | NO | OPERON (STR-CLUST) | |
Proximal regulatory components | regulato | NO | PF00165 (HMM-CLUST): transcriptional regulator, AraC family PF00816 (HMM-CLUST): H-NS histone family | |
secretin, type III associated | secretin | NO | PF03958 (HMM-CLUST): bacterial type II/III secretion system short domain protein | GO:0030254: protein secretion by the type III secretion system |
Narrow clade specific components | specific | NO | GENE_CLUSTER (MANUAL) | GO:0030254: protein secretion by the type III secretion system |
secreted proteins, effectors | target | NO | PF03518 (HMM): TIGR02101 (HMM): type III secretion target, IpaC/SipC family TIGR02553 (HMM): type III effector protein IpaD/SipD/SspD | |
type III secretion system chaperone, YscB family | y_B | NO | TIGR02513 (HMM): type III secretion system chaperone, YscB family | GO:0030254: protein secretion by the type III secretion system |
type III secretion outer membrane pore, YscC/HrcC family | y_C_h_C | YES | TIGR02516 (HMM): type III secretion outer membrane pore, YscC/HrcC family | GO:0030254: protein secretion by the type III secretion system |
type III secretion apparatus protein, YscD/HrpQ family | y_D_h_Q | YES | TIGR02500 (HMM): type III secretion apparatus protein, YscD/HrpQ family | GO:0030254: protein secretion by the type III secretion system |
type III secretion system protein, YseE family | y_E | NO | TIGR02501 (HMM): type III secretion system protein, YseE family | GO:0030254: protein secretion by the type III secretion system |
type III secretion protein, YscG family | y_G | NO | TIGR02508 (HMM): type III secretion protein, YscG family | GO:0030254: protein secretion by the type III secretion system |
type III secretion protein YopR(YscH) | y_H | NO | TIGR02509 (HMM): type III secretion effector, YopR family | GO:0030254: protein secretion by the type III secretion system |
type III secretion apparatus protein, YscI/HrpB | y_I_h_B | YES | TIGR02497 (HMM): type III secretion apparatus protein, YscI/HrpB, C-terminal domain | GO:0030254: protein secretion by the type III secretion system |
type III apparatus lipoprotein, | y_J_h_J | YES | TIGR02544 (HMM): type III secretion apparatus lipoprotein, YscJ/HrcJ family | GO:0030254: protein secretion by the type III secretion system |
YOP proteins translocation protein K | y_K | NO | PF06578 (HMM): YOP proteins translocation protein K (YscK) | GO:0030254: protein secretion by the type III secretion system |
type III secretion apparatus protein, HrpE/YscL family | y_L_h_E | YES | TIGR02499 (HMM): type III secretion apparatus protein, HrpE/YscL family | GO:0030254: protein secretion by the type III secretion system |
type III secretion ATPase | y_N_ATP | YES | TIGR02546 (HMM): type III secretion apparatus H+-transporting two-sector ATPase | GO:0030254: protein secretion by the type III secretion system |
type III secretion protein YscO | y_O | NO | PF07321 (HMM): type III secretion protein YscO | GO:0030254: protein secretion by the type III secretion system |
YscQ/HrcQ/SpaO | y_Q_h_Q | YES | TIGR02551 (HMM): type III secretion apparatus protein, YscQ/HrcQ family | GO:0030254: protein secretion by the type III secretion system |
type III secretion apparatus protein, YscR/HrcR family | y_R_h_R | YES | TIGR01102 (HMM): type III secretion apparatus protein, YscR/HrcR family | GO:0030254: protein secretion by the type III secretion system |
YscS/HrcS/SctS/EscS | y_S_h_S | YES | TIGR01403 (HMM): type III secretion protein, HrpO family | GO:0030254: protein secretion by the type III secretion system |
type III secretion protein, YscT/HrpX family | y_T_h_X | YES | TIGR01401 (HMM): type III secretion apparatus protein SpaR/YscT/HrcT | GO:0030254: protein secretion by the type III secretion system |
type III secretion protein, YscU/HrpY family | y_U_h_Y | YES | TIGR01404 (HMM): type III secretion protein, YscU/HrpY family | GO:0030254: protein secretion by the type III secretion system |
type III secretion protein, HrcV | y_V | YES | TIGR01399 (HMM): type III secretion protein, HrcV family | GO:0030254: protein secretion by the type III secretion system |
type III secretion chaperone YscW | y_W | NO | TIGR02567 (HMM): type III secretion system chaperone YscW | GO:0030254: protein secretion by the type III secretion system |
type III secretion protein, YscX family | y_X | NO | TIGR02502 (HMM): type III secretion protein, YscX family | GO:0030254: protein secretion by the type III secretion system |
Parent Properties
Accession | Name |
---|---|
GenProp0074 | virulence |
GenProp0179 | protein transport |
Sibling Properties
Accession | Name |
---|---|
GenProp0032 | pathogen of plants |
GenProp0049 | spore formation |
GenProp0051 | urease |
GenProp0056 | type IV pilus |
GenProp0062 | capsule |
GenProp0154 | intrinsic pathogen of animals |
GenProp0648 | phage shock protein regulon |
GenProp0707 | botulinum toxin system |
GenProp0849 | quorum-sensing, Bacillus PlcR-PapR system |
GenProp0053 | type II secretion |
GenProp0054 | type IV secretion |
GenProp0059 | type I secretion |
GenProp0127 | Tat (Sec-independent) protein export |
GenProp0205 | signal recognition system, bacterial |
GenProp0207 | lipoprotein localization system lolABCDE |
GenProp0209 | Sec system preprotein translocase |
GenProp0295 | prokaryotic N-terminal cleavage/methylation, type IV pilin-like |
GenProp0326 | protein sorting system, PEP-CTERM/exosortase (generic) |
GenProp0626 | protein sorting system, sortase type, LPXTG/SrtA class |
GenProp0664 | protein sorting system, sortase type, SrtB class |
GenProp0669 | protein sorting system, putative, exosortase G class |
GenProp0735 | type VI secretion |
GenProp0778 | protein sorting system, GlyGly-CTERM/rhombosortase |
GenProp0844 | accessory Sec system for serine-rich glycoprotein transport |
GenProp0845 | protein sorting system, KxYKxGKxW class |
GenProp0847 | exosporium |
GenProp0859 | protein sorting system, proteobacterial dedicated sortase type |
GenProp0904 | type VII secretion, Actinobacteria form |
GenProp0905 | type VII secretion, Firmicutes form |
GenProp0928 | OMP chaperone system: SurA-Skp-DegP |
GenProp0957 | protein sorting system, SipW class |
GenProp0978 | protein sorting system, PGF-CTERM/archaeosortase A |
GenProp0979 | protein sorting system, PEF-CTERM/archaeosortase C |
GenProp0980 | protein sorting system, putative, exosortase F class |
GenProp0983 | protein sorting system, VPXXXP-CTERM/archaeosortase B |
GenProp0985 | protein sorting system, VPDSG-CTERM/exosortase C |
GenProp0986 | protein sorting system, VPLPA-CTERM/exosortase D |
GenProp0987 | protein sorting system, cyano-PEP-CTERM class |
GenProp0989 | protein sorting system, VPEID-CTERM/exosortase E |
GenProp0993 | protein sorting system, PIP-CTERM/archaeosortase D |
GenProp0996 | protein sorting system, IPTLxxWG-CTERM/exosortase H |
GenProp0999 | Por secretion system |
GenProp1005 | protein sorting system, putative, exosortase J class |
GenProp1054 | protein sorting system, MSEP-CTERM/exosortase K |
GenProp1055 | protein sorting system, PEFG-CTERM/thaumarchaeosortase |
GenProp1074 | type V secretion |
GenProp1087 | protein sorting system, vault protein/exosortase N |
GenProp1102 | protein sorting system, CGP-CTERM/unknown of Thermococcaceae |
GenProp1103 | protein sorting system, Synergist-CTERM/unknown of Synergistetes |