Genome Property Definition Page

Nametype VII secretion, Actinobacteria form
DescriptionType VII secretion (T7S) is also called ESAT-6-, SNM-, and ESX-secretion. It occurs in Mycobacterium, which has an impermeable cell envelope that contains long-chain mycolic acids in an outer membrane, and T7S provides a means to transport proteins through this barrier. Multiple T7S loci can occur in one species, with different secretion targets for different systems. The system includes a subtilisin-like protease called mycosin and membrane proteins with a new nomenclature in starting with ecc (esx conserved component).
JCVI RoleProtein and peptide secretion and trafficking
Parent PropertyGenProp0179: protein transport
Literature References
[ 1 ]Bitter W, Houben EN, Bottai D, Brodin P, Brown EJ, Cox JS, Derbyshire K, Fortune SM, Gao LY, Liu J, Gey van Pittius NC, Pym AS, Rubin EJ, Sherman DR, Cole ST, Brosch R  Systematic genetic nomenclature for type VII secretion systems.  PLoS Pathog. 2009 Oct;5(10):e1000507. Epub 2009 Oct 30.  PMID 19876390

Step NameStep NumRequiredEvidence (Method)Evidence Go Terms
type VII secretion AAA-ATPase EccAT7_EccAYESTIGR03922 (HMM): type VII secretion AAA-ATPase EccA
type VII secretion transmembrane protein EccBT7_EccBYESTIGR03919 (HMM): type VII secretion protein EccB
type VII secretion protein EccCT7_EccCYESTIGR03924 (HMM): type VII secretion protein EccCa
TIGR03925 (HMM): type VII secretion protein EccCb
type VII secretion integral membrane protein EccDT7_EccDYESTIGR03920 (HMM): type VII secretion integral membrane protein EccD
type VII secretion transmembrane protein EccET7_EccEYESTIGR03923 (HMM): type VII secretion protein EccE
WXG100 family type VII secretion targetT7_WxGYESPF06013 (HMM-CLUST): WXG motif protein
TIGR03930 (HMM-CLUST): WXG100 family type VII secretion target
type VII secretion-associated protein, Rv3446c familyT7_aNOTIGR03931 (HMM): type VII secretion-associated protein, Rv3446c family
mycosinT7_mycoYESTIGR03921 (HMM): type VII secretion-associated serine protease mycosin

Parent Properties
GenProp0179protein transport

Sibling Properties
GenProp0052type III secretion
GenProp0053type II secretion
GenProp0054type IV secretion
GenProp0059type I secretion
GenProp0127Tat (Sec-independent) protein export
GenProp0205signal recognition system, bacterial
GenProp0207lipoprotein localization system lolABCDE
GenProp0209Sec system preprotein translocase
GenProp0295prokaryotic N-terminal cleavage/methylation, type IV pilin-like
GenProp0326protein sorting system, PEP-CTERM/exosortase (generic)
GenProp0626protein sorting system, sortase type, LPXTG/SrtA class
GenProp0664protein sorting system, sortase type, SrtB class
GenProp0669protein sorting system, putative, exosortase G class
GenProp0735type VI secretion
GenProp0778protein sorting system, GlyGly-CTERM/rhombosortase
GenProp0844accessory Sec system for serine-rich glycoprotein transport
GenProp0845protein sorting system, KxYKxGKxW class
GenProp0859protein sorting system, proteobacterial dedicated sortase type
GenProp0905type VII secretion, Firmicutes form
GenProp0928OMP chaperone system: SurA-Skp-DegP
GenProp0957protein sorting system, SipW class
GenProp0978protein sorting system, PGF-CTERM/archaeosortase A
GenProp0979protein sorting system, PEF-CTERM/archaeosortase C
GenProp0980protein sorting system, putative, exosortase F class
GenProp0983protein sorting system, VPXXXP-CTERM/archaeosortase B
GenProp0985protein sorting system, VPDSG-CTERM/exosortase C
GenProp0986protein sorting system, VPLPA-CTERM/exosortase D
GenProp0987protein sorting system, cyano-PEP-CTERM class
GenProp0989protein sorting system, VPEID-CTERM/exosortase E
GenProp0993protein sorting system, PIP-CTERM/archaeosortase D
GenProp0996protein sorting system, IPTLxxWG-CTERM/exosortase H
GenProp0999Por secretion system
GenProp1005protein sorting system, putative, exosortase J class
GenProp1054protein sorting system, MSEP-CTERM/exosortase K
GenProp1055protein sorting system, PEFG-CTERM/thaumarchaeosortase
GenProp1074type V secretion
GenProp1087protein sorting system, vault protein/exosortase N
GenProp1102protein sorting system, CGP-CTERM/unknown of Thermococcaceae
GenProp1103protein sorting system, Synergist-CTERM/unknown of Synergistetes