Genome Property Definition Page

NameSec system preprotein translocase
DescriptionThis property describes the bacterial preprotein translocase Sec. The analogous process occurs in eukaryotes and archaea (little studied in the archaea), but the component proteins are different enough not to be described by the same set of hidden Markov models. SecB is a cytosolic export-specific chaperone in E. coli and some related species, but is not broadly distributed. SecA, the ATPase that powers the translocase, is a peripheral membrane protein. SecY, SecE, and SecG form the heterotrimeric translocase, although SecG is not essential at some temperatures. SecD, SecG, and YajC form an accessory complex that may prevent backsliding of proteins being translocated, and may not be essential proteins.
JCVI RoleProtein and peptide secretion and trafficking
Parent PropertyGenProp0179: protein transport

Step NameStep NumRequiredEvidence (Method)Evidence Go Terms
Inner membrane protein oxaAOxaANOTIGR03593 (HMM): membrane protein insertase, YidC/Oxa1 family, N-terminal domain
TIGR03592 (HMM): membrane protein insertase, YidC/Oxa1 family
PF02096 (HMM): 60Kd inner membrane protein
SecA peripheral ATPaseSecAYESTIGR00963 (HMM): preprotein translocase, SecA subunit
SecB cytosolic chaperoneSecBNOTIGR00809 (HMM): protein-export chaperone SecB
SecD accessory complex subunitSecDNOTIGR01129 (HMM): protein-export membrane protein SecD
SecE core heterotrimer subunitSecEYESTIGR00964 (HMM): preprotein translocase, SecE subunit
SecF accessory complex subunitSecFNOTIGR00966 (HMM): protein-export membrane protein SecF
SecG core heterotrimer subunitSecGYESTIGR00810 (HMM): preprotein translocase, SecG subunit
SecY core heterotrimer subunitSecYYESTIGR00967 (HMM): preprotein translocase, SecY subunit
YajC accessory complex subunitYajCNOTIGR00739 (HMM): preprotein translocase, YajC subunit

Parent Properties
GenProp0179protein transport

Sibling Properties
GenProp0052type III secretion
GenProp0053type II secretion
GenProp0054type IV secretion
GenProp0059type I secretion
GenProp0127Tat (Sec-independent) protein export
GenProp0205signal recognition system, bacterial
GenProp0207lipoprotein localization system lolABCDE
GenProp0295prokaryotic N-terminal cleavage/methylation, type IV pilin-like
GenProp0326protein sorting system, PEP-CTERM/exosortase (generic)
GenProp0626protein sorting system, sortase type, LPXTG/SrtA class
GenProp0664protein sorting system, sortase type, SrtB class
GenProp0669protein sorting system, putative, exosortase G class
GenProp0735type VI secretion
GenProp0778protein sorting system, GlyGly-CTERM/rhombosortase
GenProp0844accessory Sec system for serine-rich glycoprotein transport
GenProp0845protein sorting system, KxYKxGKxW class
GenProp0859protein sorting system, proteobacterial dedicated sortase type
GenProp0904type VII secretion, Actinobacteria form
GenProp0905type VII secretion, Firmicutes form
GenProp0928OMP chaperone system: SurA-Skp-DegP
GenProp0957protein sorting system, SipW class
GenProp0978protein sorting system, PGF-CTERM/archaeosortase A
GenProp0979protein sorting system, PEF-CTERM/archaeosortase C
GenProp0980protein sorting system, putative, exosortase F class
GenProp0983protein sorting system, VPXXXP-CTERM/archaeosortase B
GenProp0985protein sorting system, VPDSG-CTERM/exosortase C
GenProp0986protein sorting system, VPLPA-CTERM/exosortase D
GenProp0987protein sorting system, cyano-PEP-CTERM class
GenProp0989protein sorting system, VPEID-CTERM/exosortase E
GenProp0993protein sorting system, PIP-CTERM/archaeosortase D
GenProp0996protein sorting system, IPTLxxWG-CTERM/exosortase H
GenProp0999Por secretion system
GenProp1005protein sorting system, putative, exosortase J class
GenProp1054protein sorting system, MSEP-CTERM/exosortase K
GenProp1055protein sorting system, PEFG-CTERM/thaumarchaeosortase
GenProp1074type V secretion
GenProp1087protein sorting system, vault protein/exosortase N
GenProp1102protein sorting system, CGP-CTERM/unknown of Thermococcaceae
GenProp1103protein sorting system, Synergist-CTERM/unknown of Synergistetes