Genome Property Definition Page
| Accession | GenProp0059 |
| Name | type I secretion |
| Type | SYSTEM |
| Description | A type I protein secretion system is an ABC transporter. The system is Sec-independent. ATP drives the transport of target proteins across both inner and outer membranes and into the extracellular medium. There is no cleaved N-terminal signal sequence. Instead, the type I system recognizes C-terminal information, localized to the last 50 amino acids or less. Characteristic sequence found nearby, such as repeats of the motif GGXGXDXXX in Erwinia, may play a supporting role, possibly for chaperoning the rest of the protein rather than for recognition of the export signal (reference PMID:11157948). This property does NOT cover ABC transporter-mediated processing and secretion of class II bacteriocins of certain Gram-positive bacteria, because of the following differences: there is no outer membrane to traverse and no TolC homolog. N-terminal signal recognition and proteolytic processing (at a GG motif) occurs together with transport. Finally, the secreted peptides are small, and lack the GGXGXDXXX motif repeated in larger proteins of class I secretion systems. |
| JCVI Role | Protein and peptide secretion and trafficking |
| Parent Property | GenProp0179: protein transport |
| Gene Ontology Term | GO:0030253: protein secretion by the type I secretion system (biological_process) |
Components
| Step Name | Step Num | Required | Evidence (Method) | Evidence Go Terms |
|---|---|---|---|---|
| type I secretion ATPase | ATPase | YES | TIGR01842 (HMM): type I secretion system ATPase TIGR01846 (HMM): type I secretion system ATPase TIGR03375 (HMM): type I secretion system ATPase | GO:0030253: protein secretion by the type I secretion system GO:0030253: protein secretion by the type I secretion system GO:0030253: protein secretion by the type I secretion system |
| type I secretion membrane fusion protein | MFP | YES | TIGR01843 (HMM): type I secretion membrane fusion protein, HlyD family | GO:0030253: protein secretion by the type I secretion system |
| type I secretion outer membrane protein | OMP | YES | TIGR01844 (HMM): type I secretion outer membrane protein, TolC family | GO:0030253: protein secretion by the type I secretion system |
| type I secreted proteins GGXGXDXXX repeats | example | YES | PF00353 (HMM): type I secretion target GGXGXDXXX repeat |
Parent Properties
| Accession | Name |
|---|---|
| GenProp0179 | protein transport |
Sibling Properties
| Accession | Name |
|---|---|
| GenProp0052 | type III secretion |
| GenProp0053 | type II secretion |
| GenProp0054 | type IV secretion |
| GenProp0127 | Tat (Sec-independent) protein export |
| GenProp0205 | signal recognition system, bacterial |
| GenProp0207 | lipoprotein localization system lolABCDE |
| GenProp0209 | Sec system preprotein translocase |
| GenProp0295 | prokaryotic N-terminal cleavage/methylation, type IV pilin-like |
| GenProp0326 | protein sorting system, PEP-CTERM/exosortase (generic) |
| GenProp0626 | protein sorting system, sortase type, LPXTG/SrtA class |
| GenProp0664 | protein sorting system, sortase type, SrtB class |
| GenProp0669 | protein sorting system, putative, exosortase G class |
| GenProp0735 | type VI secretion |
| GenProp0778 | protein sorting system, GlyGly-CTERM/rhombosortase |
| GenProp0844 | accessory Sec system for serine-rich glycoprotein transport |
| GenProp0845 | protein sorting system, KxYKxGKxW class |
| GenProp0847 | exosporium |
| GenProp0859 | protein sorting system, proteobacterial dedicated sortase type |
| GenProp0904 | type VII secretion, Actinobacteria form |
| GenProp0905 | type VII secretion, Firmicutes form |
| GenProp0928 | OMP chaperone system: SurA-Skp-DegP |
| GenProp0957 | protein sorting system, SipW class |
| GenProp0978 | protein sorting system, PGF-CTERM/archaeosortase A |
| GenProp0979 | protein sorting system, PEF-CTERM/archaeosortase C |
| GenProp0980 | protein sorting system, putative, exosortase F class |
| GenProp0983 | protein sorting system, VPXXXP-CTERM/archaeosortase B |
| GenProp0985 | protein sorting system, VPDSG-CTERM/exosortase C |
| GenProp0986 | protein sorting system, VPLPA-CTERM/exosortase D |
| GenProp0987 | protein sorting system, cyano-PEP-CTERM class |
| GenProp0989 | protein sorting system, VPEID-CTERM/exosortase E |
| GenProp0993 | protein sorting system, PIP-CTERM/archaeosortase D |
| GenProp0996 | protein sorting system, IPTLxxWG-CTERM/exosortase H |
| GenProp0999 | Por secretion system |
| GenProp1005 | protein sorting system, putative, exosortase J class |
| GenProp1054 | protein sorting system, MSEP-CTERM/exosortase K |
| GenProp1055 | protein sorting system, PEFG-CTERM/thaumarchaeosortase |
| GenProp1074 | type V secretion |
| GenProp1087 | protein sorting system, vault protein/exosortase N |
| GenProp1102 | protein sorting system, CGP-CTERM/unknown of Thermococcaceae |
| GenProp1103 | protein sorting system, Synergist-CTERM/unknown of Synergistetes |