Genome Property Definition Page

Nametype I secretion
DescriptionA type I protein secretion system is an ABC transporter. The system is Sec-independent. ATP drives the transport of target proteins across both inner and outer membranes and into the extracellular medium. There is no cleaved N-terminal signal sequence. Instead, the type I system recognizes C-terminal information, localized to the last 50 amino acids or less. Characteristic sequence found nearby, such as repeats of the motif GGXGXDXXX in Erwinia, may play a supporting role, possibly for chaperoning the rest of the protein rather than for recognition of the export signal (reference PMID:11157948). This property does NOT cover ABC transporter-mediated processing and secretion of class II bacteriocins of certain Gram-positive bacteria, because of the following differences: there is no outer membrane to traverse and no TolC homolog. N-terminal signal recognition and proteolytic processing (at a GG motif) occurs together with transport. Finally, the secreted peptides are small, and lack the GGXGXDXXX motif repeated in larger proteins of class I secretion systems.
JCVI RoleProtein and peptide secretion and trafficking
Parent PropertyGenProp0179: protein transport
Gene Ontology TermGO:0030253: protein secretion by the type I secretion system (biological_process)

Step NameStep NumRequiredEvidence (Method)Evidence Go Terms
type I secretion ATPaseATPaseYESTIGR01842 (HMM): type I secretion system ATPase
TIGR01846 (HMM): type I secretion system ATPase
TIGR03375 (HMM): type I secretion system ATPase
GO:0030253: protein secretion by the type I secretion system
GO:0030253: protein secretion by the type I secretion system
GO:0030253: protein secretion by the type I secretion system
type I secretion membrane fusion proteinMFPYESTIGR01843 (HMM): type I secretion membrane fusion protein, HlyD familyGO:0030253: protein secretion by the type I secretion system
type I secretion outer membrane proteinOMPYESTIGR01844 (HMM): type I secretion outer membrane protein, TolC familyGO:0030253: protein secretion by the type I secretion system
type I secreted proteins GGXGXDXXX repeatsexampleYESPF00353 (HMM): type I secretion target GGXGXDXXX repeat

Parent Properties
GenProp0179protein transport

Sibling Properties
GenProp0052type III secretion
GenProp0053type II secretion
GenProp0054type IV secretion
GenProp0127Tat (Sec-independent) protein export
GenProp0205signal recognition system, bacterial
GenProp0207lipoprotein localization system lolABCDE
GenProp0209Sec system preprotein translocase
GenProp0295prokaryotic N-terminal cleavage/methylation, type IV pilin-like
GenProp0326protein sorting system, PEP-CTERM/exosortase (generic)
GenProp0626protein sorting system, sortase type, LPXTG/SrtA class
GenProp0664protein sorting system, sortase type, SrtB class
GenProp0669protein sorting system, putative, exosortase G class
GenProp0735type VI secretion
GenProp0778protein sorting system, GlyGly-CTERM/rhombosortase
GenProp0844accessory Sec system for serine-rich glycoprotein transport
GenProp0845protein sorting system, KxYKxGKxW class
GenProp0859protein sorting system, proteobacterial dedicated sortase type
GenProp0904type VII secretion, Actinobacteria form
GenProp0905type VII secretion, Firmicutes form
GenProp0928OMP chaperone system: SurA-Skp-DegP
GenProp0957protein sorting system, SipW class
GenProp0978protein sorting system, PGF-CTERM/archaeosortase A
GenProp0979protein sorting system, PEF-CTERM/archaeosortase C
GenProp0980protein sorting system, putative, exosortase F class
GenProp0983protein sorting system, VPXXXP-CTERM/archaeosortase B
GenProp0985protein sorting system, VPDSG-CTERM/exosortase C
GenProp0986protein sorting system, VPLPA-CTERM/exosortase D
GenProp0987protein sorting system, cyano-PEP-CTERM class
GenProp0989protein sorting system, VPEID-CTERM/exosortase E
GenProp0993protein sorting system, PIP-CTERM/archaeosortase D
GenProp0996protein sorting system, IPTLxxWG-CTERM/exosortase H
GenProp0999Por secretion system
GenProp1005protein sorting system, putative, exosortase J class
GenProp1054protein sorting system, MSEP-CTERM/exosortase K
GenProp1055protein sorting system, PEFG-CTERM/thaumarchaeosortase
GenProp1074type V secretion
GenProp1087protein sorting system, vault protein/exosortase N
GenProp1102protein sorting system, CGP-CTERM/unknown of Thermococcaceae
GenProp1103protein sorting system, Synergist-CTERM/unknown of Synergistetes