Genome Property Definition Page

Nametype V secretion
DescriptionType V secretion systems (T5SS) are most commonly the classical monomeric autotransporters (type Va), in which a C-terminal outer membrane (OM) beta barrel domain functions as a translocator through the OM for an N-terminal passenger domain of the same polypeptide chain. Many type Va autotransporters cleave autocatalytically to release the passenger domain. In type Vb systems, called two-partner secretion systems, the passenger and translocator domains are in separate polypeptides. Additional variant forms Vc, Vd, and Ve have also been described. A special type of signal peptide (PF13018) tethers the nascent polypeptide chain to the Sec apparatus in some autotransporters to allow proper completion of C-terminal domain folding in the OM.
JCVI RoleProtein and peptide secretion and trafficking
Parent PropertyGenProp0179: protein transport
Literature References
[ 1 ]Leo JC, Grin I, Linke D  Type V secretion: mechanism(s) of autotransport through the bacterial outer membrane.  Philos Trans R Soc Lond B Biol Sci. 2012 Apr 19;367(1592):1088-101.  PMID 22411980
Gene Ontology TermGO:0046819: protein secretion by the type V secretion system (biological_process)

Step NameStep NumRequiredEvidence (Method)Evidence Go Terms
type V secretion system signal peptideT5SSsigNOPF13018 (HMM): type V secretion system signal peptideGO:0046819: protein secretion by the type V secretion system
T5SS outer membrane translocatorautotranYESTIGR01414 (HMM): outer membrane autotransporter barrel domain
PF03865 (HMM): hemolysin secretion/activation protein, ShlB/FhaC/HecB family
GO:0046819: protein secretion by the type V secretion system
GO:0046819: protein secretion by the type V secretion system

Parent Properties
GenProp0179protein transport

Sibling Properties
GenProp0052type III secretion
GenProp0053type II secretion
GenProp0054type IV secretion
GenProp0059type I secretion
GenProp0127Tat (Sec-independent) protein export
GenProp0205signal recognition system, bacterial
GenProp0207lipoprotein localization system lolABCDE
GenProp0209Sec system preprotein translocase
GenProp0295prokaryotic N-terminal cleavage/methylation, type IV pilin-like
GenProp0326protein sorting system, PEP-CTERM/exosortase (generic)
GenProp0626protein sorting system, sortase type, LPXTG/SrtA class
GenProp0664protein sorting system, sortase type, SrtB class
GenProp0669protein sorting system, putative, exosortase G class
GenProp0735type VI secretion
GenProp0778protein sorting system, GlyGly-CTERM/rhombosortase
GenProp0844accessory Sec system for serine-rich glycoprotein transport
GenProp0845protein sorting system, KxYKxGKxW class
GenProp0859protein sorting system, proteobacterial dedicated sortase type
GenProp0904type VII secretion, Actinobacteria form
GenProp0905type VII secretion, Firmicutes form
GenProp0928OMP chaperone system: SurA-Skp-DegP
GenProp0957protein sorting system, SipW class
GenProp0978protein sorting system, PGF-CTERM/archaeosortase A
GenProp0979protein sorting system, PEF-CTERM/archaeosortase C
GenProp0980protein sorting system, putative, exosortase F class
GenProp0983protein sorting system, VPXXXP-CTERM/archaeosortase B
GenProp0985protein sorting system, VPDSG-CTERM/exosortase C
GenProp0986protein sorting system, VPLPA-CTERM/exosortase D
GenProp0987protein sorting system, cyano-PEP-CTERM class
GenProp0989protein sorting system, VPEID-CTERM/exosortase E
GenProp0993protein sorting system, PIP-CTERM/archaeosortase D
GenProp0996protein sorting system, IPTLxxWG-CTERM/exosortase H
GenProp0999Por secretion system
GenProp1005protein sorting system, putative, exosortase J class
GenProp1054protein sorting system, MSEP-CTERM/exosortase K
GenProp1055protein sorting system, PEFG-CTERM/thaumarchaeosortase
GenProp1087protein sorting system, vault protein/exosortase N
GenProp1102protein sorting system, CGP-CTERM/unknown of Thermococcaceae
GenProp1103protein sorting system, Synergist-CTERM/unknown of Synergistetes