| Accession | GenProp0757 |
| Name | quorum-sensing, autoinducer-2 system |
| Type | SYSTEM |
| Description | S-ribosylhomocysteine lyase, 4.4.1.21, is LuxS, an iron(2+)-containing protein. Its immediate product, 4,5-dihydroxypentan-2,3-dione, cyclizes spontaneously and binds borate to become autoinducer-2 (AI-2), a quorum-sensing molecule produced and recognized by a wide range of bacteria. LuxS serves as a marker for this system, while MTA/SAH nucleosidase is essential both for this and other systems. Many clade-specific proteins interact with this system but are not currently represented as part of this genome property. |
| JCVI Role | Other |
| Parent Property | GenProp0077: natural products biosynthesis
GenProp1048: quorum-sensing, biofilm formation, and developmental systems
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| Literature References | [ 1 ] Lee JE, Luong W, Huang DJ, Cornell KA, Riscoe MK, Howell PL Mutational analysis of a nucleosidase involved in quorum-sensing autoinducer-2 biosynthesis. Biochemistry. 2005 Aug 23;44(33):11049-57. PMID 16101288
[ 2 ] Sun J, Daniel R, Wagner-Dobler I, Zeng AP Is autoinducer-2 a universal signal for interspecies communication: a comparative genomic and phylogenetic analysis of the synthesis and signal transduction pathways. BMC Evol Biol. 2004 Sep 29;4:36. PMID 15456522
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| Gene Ontology Term | GO:0009372: quorum sensing (biological_process)
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| Accession | Name |
|---|
| GenProp0014 | polyketide biosynthesis, type I |
| GenProp0015 | polyketide biosynthesis, type II |
| GenProp0040 | thiotemplate type non-ribosomal peptide biosynthesis |
| GenProp0169 | hybrid NRPS-PKS natural pruduct biosynthesis genes |
| GenProp0724 | phosphonoacetaldehyde biosynthesis from phosphoenolpyruvate |
| GenProp0758 | lycopene biosynthesis from IPP |
| GenProp0770 | siderophore biosynthesis |
| GenProp0807 | bacteriocin system, heterocycle biosynthesis group |
| GenProp0808 | bacteriocin system, TIGR01847 leader group |
| GenProp0809 | bacteriocin system, lactococcin 972 group |
| GenProp0823 | violacein biosynthesis |
| GenProp0825 | bacteriocin system, circular bacteriocin group |
| GenProp0853 | lantibiotic system, gallidermin/epidermin family |
| GenProp0861 | bacteriocin system, NHLP (nif11/nitrile hydratase leader peptide) transport group |
| GenProp0901 | post-ribosomal natural product synthesis system, Burkholderia TOMM-type |
| GenProp0919 | SCIFF/radical SAM Clostridial gene pair |
| GenProp0920 | radical SAM Y_X(10)_GDL system |
| GenProp0921 | radical SAM pair and His-Xaa-Ser repeats peptide |
| GenProp0936 | bacteriocin system, sporulation delay protein group |
| GenProp0945 | radical SAM maturase bacteriocin system, CLI_3235 type |
| GenProp0954 | radical SAM-cylized peptide, Pep1357C family |
| GenProp0955 | modified peptide/radical SAM maturase system, YydFG family |
| GenProp0956 | radical SAM maturase/selenobacteriocin system |
| GenProp0962 | methanobactin biosynthesis, Mb-OB3b family |
| GenProp0967 | radical SAM maturase system, CXXX repeats type |
| GenProp0982 | radical SAM maturase system, FibroRumin system |
| GenProp0984 | radical SAM maturase system, GG-Bacteroidales group |
| GenProp0990 | cobaltopeptin biosynthesis |
| GenProp0991 | ATP-grasp maturase system, microviridin/marinostatin class |
| GenProp1000 | ATP-grasp maturase system, uncharacterized |
| GenProp1002 | grasp-with-spasm peptide maturase system |
| GenProp1003 | cysteine S-glycopeptide biosynthesis, sublancin family |
| GenProp1029 | radical SAM/SPASM system SynChlorMet |
| GenProp1037 | radical SAM/SPASM system GRRM |
| GenProp1052 | geopeptide radical SAM/SPASM maturase system |
| GenProp1062 | radical SAM/SPASM system Clo7bot |
| GenProp1065 | radical SAM/SPASM TIGR04347/TIGR04031 system |
| GenProp1078 | sporulation killing factor system |
| GenProp1083 | cyanobactin-like ribosomal natural product biosynthesis |
| GenProp1084 | enduracididine biosynthesis |
| GenProp1090 | radical SAM/SPASM maturase system XYE |
| GenProp1097 | bacimethrin biosynthesis |
| GenProp1098 | 3-methylarginine biosynthesis |
| GenProp0652 | exopolysaccharide biosynthesis, exosortase A-associated |
| GenProp0655 | exopolysaccharide biosynthesis, exosortase B-associated |
| GenProp0658 | cellulose biosynthesis |
| GenProp0849 | quorum-sensing, Bacillus PlcR-PapR system |
| GenProp1011 | quorum-sensing system, cyclic peptide-mediated |
