| Accession | GenProp0015 |
| Name | polyketide biosynthesis, type II |
| Type | TEST |
| Description | Allowed states:
YES
NO
Polyketides are an important class of natural product which are assembled by the sequential addition of units containing at minimum one acetate group. Polyketides include many antibiotics and other compounds of biological and economic importance. Polyketides may be synthesized by large multi-domain proteins (Type I polyketide synthetases) which carry out a so-called thio-template program in which successive modules of domains add single units to the growing end of the polyketide chain, modify the newly added piece (usually a series of reductions) and pass the chain on to the next module. The overall mechanism is similar to that observed in the biosynthesis of fatty acids in animals via the Type I fatty acid synthases. By contrast, Type II polyketide synthetases, which are similar to the Type II fatty acid synthases found in bacteria and plants, consist of separate proteins for each of the various functions involved in the overall process. Plant chalcones and stilbenes are synthesized by yet a third style of synthetase in which a single condensing enzyme is active for all condensation steps.
Many of the constituent domains of type II polyketide synthetases have been defined by HMM models. These include acyl transferase (PF00698), beta-ketoacyl-synthase (PF00109, PF02801), acyl carrier protein (PF00550) and thioesterase (PF00975) domains. Other commonly found domains which have not yet been represented by HMMs include ketoreductase, dehydratase and enoyl reductase domains.
This genome property will be set to YES if several genes containing these domains are found in a gene cluster along with other evidence indicating that this gene cluster is responsible for the biosynthesis of a polyketide natural product. A NULL value indicates that the genome has not yet been evaluated with regard to this property. |
| Parent Property | GenProp0077: natural products biosynthesis
|
| Gene Ontology Term | GO:0030639: polyketide biosynthetic process (biological_process)
|
| Accession | Name |
|---|
| GenProp0014 | polyketide biosynthesis, type I |
| GenProp0040 | thiotemplate type non-ribosomal peptide biosynthesis |
| GenProp0169 | hybrid NRPS-PKS natural pruduct biosynthesis genes |
| GenProp0724 | phosphonoacetaldehyde biosynthesis from phosphoenolpyruvate |
| GenProp0757 | quorum-sensing, autoinducer-2 system |
| GenProp0758 | lycopene biosynthesis from IPP |
| GenProp0770 | siderophore biosynthesis |
| GenProp0807 | bacteriocin system, heterocycle biosynthesis group |
| GenProp0808 | bacteriocin system, TIGR01847 leader group |
| GenProp0809 | bacteriocin system, lactococcin 972 group |
| GenProp0823 | violacein biosynthesis |
| GenProp0825 | bacteriocin system, circular bacteriocin group |
| GenProp0853 | lantibiotic system, gallidermin/epidermin family |
| GenProp0861 | bacteriocin system, NHLP (nif11/nitrile hydratase leader peptide) transport group |
| GenProp0901 | post-ribosomal natural product synthesis system, Burkholderia TOMM-type |
| GenProp0919 | SCIFF/radical SAM Clostridial gene pair |
| GenProp0920 | radical SAM Y_X(10)_GDL system |
| GenProp0921 | radical SAM pair and His-Xaa-Ser repeats peptide |
| GenProp0936 | bacteriocin system, sporulation delay protein group |
| GenProp0945 | radical SAM maturase bacteriocin system, CLI_3235 type |
| GenProp0954 | radical SAM-cylized peptide, Pep1357C family |
| GenProp0955 | modified peptide/radical SAM maturase system, YydFG family |
| GenProp0956 | radical SAM maturase/selenobacteriocin system |
| GenProp0962 | methanobactin biosynthesis, Mb-OB3b family |
| GenProp0967 | radical SAM maturase system, CXXX repeats type |
| GenProp0982 | radical SAM maturase system, FibroRumin system |
| GenProp0984 | radical SAM maturase system, GG-Bacteroidales group |
| GenProp0990 | cobaltopeptin biosynthesis |
| GenProp0991 | ATP-grasp maturase system, microviridin/marinostatin class |
| GenProp1000 | ATP-grasp maturase system, uncharacterized |
| GenProp1002 | grasp-with-spasm peptide maturase system |
| GenProp1003 | cysteine S-glycopeptide biosynthesis, sublancin family |
| GenProp1029 | radical SAM/SPASM system SynChlorMet |
| GenProp1037 | radical SAM/SPASM system GRRM |
| GenProp1052 | geopeptide radical SAM/SPASM maturase system |
| GenProp1062 | radical SAM/SPASM system Clo7bot |
| GenProp1065 | radical SAM/SPASM TIGR04347/TIGR04031 system |
| GenProp1078 | sporulation killing factor system |
| GenProp1083 | cyanobactin-like ribosomal natural product biosynthesis |
| GenProp1084 | enduracididine biosynthesis |
| GenProp1090 | radical SAM/SPASM maturase system XYE |
| GenProp1097 | bacimethrin biosynthesis |
| GenProp1098 | 3-methylarginine biosynthesis |
