Genome Property Definition Page

Nameexopolysaccharide biosynthesis, exosortase A-associated
DescriptionAt least 30 different bacterial species known so far have the PEP-CTERM/exosortase system believed to process proteins analogously to the LPXTG/sortase system. Genes associated with this processing are found among exopolysaccharide biosynthesis genes, suggesting that PEP-CTERM proteins are part of this exopolysaccharide system, and therefore are likely to be transported across the outer membrane. This property represents a panel of exopolysaccharide biosynthesis genes where each belongs to a subfamily that marks its host gene as carrying the PEP-CTERM/exopolysaccharide system.
JCVI RoleBiosynthesis and degradation of surface polysaccharides and lipopolysaccharides
Parent PropertyGenProp0186: storage and structural polymer biosynthesis
GenProp1048: quorum-sensing, biofilm formation, and developmental systems
Literature References
[ 1 ]Haft DH, Paulsen IT, Ward N, Selengut JD  Exopolysaccharide-associated protein sorting in environmental organisms: the PEP-CTERM/EpsH system. Application of a novel phylogenetic profiling heuristic.  BMC Biol. 2006 Aug 24;4(1):29.  PMID 16930487

Step NameStep NumRequiredEvidence (Method)Evidence Go Terms
ATPase, exosortase type 1 regionATPaseYESTIGR03015 (HMM): putative secretion ATPase, PEP-CTERM locus subfamily
exosortase EpsH, type 1EpsH1YESTIGR02602 (HMM-CLUST): exosortase
TIGR03109 (HMM): exosortase A
EpsIEpsINOTIGR02914 (HMM-CLUST): EpsI family protein
hydrolases (1 and 2), exosortase system type 1 associatedHydrolNOTIGR03100 (HMM): exosortase A system-associated hydrolase 1
TIGR03101 (HMM): exosortase A system-associated hydrolase 2
uncharacterized protein, EpsL-relatedL_unchrYESTIGR03016 (HMM): uncharacterized protein, PEP-CTERM system associated
acyl-CoA ligase, PEP-CTERM/EpsH1 associatedLig1NOTIGR03098 (HMM): acyl-CoA ligase (AMP-forming), exosortase A-associated
clustered asparagine synthase homologNsynthNOTIGR01536 (HMM-CLUST): asparagine synthase (glutamine-hydrolyzing)
TIGR03108 (HMM): exosortase A system-associated amidotransferase 1
putative transmembrane histidine kinase, PEP-CTERM systemPrsKYESTIGR02916 (HMM): putative PEP-CTERM system histidine kinase
putative response regulator, PEP-CTERM systemPrsRYESTIGR02915 (HMM): PEP-CTERM-box response regulator transcription factor
TPR repeat putative lipoprotein, PEP-CTERM systemPrsTYESTIGR02917 (HMM): putative PEP-CTERM system TPR-repeat lipoprotein
decarboxylase, exosortase system type 1 associateddCO2aseNOTIGR03099 (HMM): pyridoxal-dependent decarboxylase, exosortase A system-associated
polysaccharide deacetylasede_acetYESTIGR03006 (HMM): polysaccharide deacetylase family protein, PEP-CTERM locus subfamily
polysaccharide export proteinexportYESTIGR03027 (HMM): putative polysaccharide export protein, PEP-CTERM sytem-associated
FemAB-related proteinfemABYESTIGR03019 (HMM): FemAB-related protein, PEP-CTERM system-associated
sugar transferaseprsBYESTIGR03013 (HMM): sugar transferase, PEP-CTERM system associated
sugar transferase, PEP-CTERM/EpsH1-associatedstp1NOTIGR03087 (HMM): sugar transferase, PEP-CTERM/EpsH1 system associated
sugar transferase, PEP-CTERM/EpsH1-associatedstp2NOTIGR03088 (HMM): sugar transferase, PEP-CTERM/EpsH1 system associated
sugar transferase, PEP-CTERM/exosortase 1-associatedstp3NOTIGR04063 (HMM): PEP-CTERM/exosortase A-associated glycosyltransferase, Daro_2409 family
conserved region, upstream of non-CTERM geneup?NOpromo1a (MAN-HMM)

promo1b (MAN-HMM)
conserved region upstream of CTERM genes in proteobacteriaupstreamNOpromo1a (MAN-HMM)

promo1b (MAN-HMM)
probable O-glycosylation ligasewaaLNOTIGR03097 (HMM): probable O-glycosylation ligase, exosortase A-associated
tryosine autokinasewzc1YESTIGR03018 (HMM): exopolysaccharide/PEP-CTERM locus tyrosine autokinase
polysaccharide chain length determinantwzz1YESTIGR03007 (HMM): polysaccharide chain length determinant protein, PEP-CTERM locus subfamily

Parent Properties
GenProp0186storage and structural polymer biosynthesis
GenProp1048quorum-sensing, biofilm formation, and developmental systems

Sibling Properties
GenProp0055polyhydroxyalkanoic acids
GenProp0156cyanophycin-like storage polymers
GenProp0158peptidoglycan(murein) biosynthesis
GenProp0168glycogen system
GenProp0183dTDP-L-rhamnose biosynthesis from dTDP-4-dehydro-L-rhamnose
GenProp0297lipopolysaccharide biosynthesis
GenProp0655exopolysaccharide biosynthesis, exosortase B-associated
GenProp0658cellulose biosynthesis
GenProp0793CMP-N-acetylneuraminate biosynthesis from UDP-N-acetylglucosamine
GenProp0822poly(gamma-glutamic acid) biosynthesis
GenProp0906poly-beta-1,6 N-acetyl-D-glucosamine system, IcaADBC type
GenProp0907poly-beta-1,6 N-acetyl-D-glucosamine system, PgaABCD type
GenProp0757quorum-sensing, autoinducer-2 system
GenProp0849quorum-sensing, Bacillus PlcR-PapR system
GenProp1011quorum-sensing system, cyclic peptide-mediated