Genome Property Definition Page

Name3-methylarginine biosynthesis
Description3-methylarginine can be a natural product in its own right, or a precursor of another natural product, such as arginomycin. The aminotransferase catalyzes the first and third steps of the pathway, removing the alpha-amino group from arginine, later replacing it on the beta-methylated form. The second step is catalyzed by a C-methyltransferase that acts on 2-ketoarginine at the 3-position.
JCVI RoleBiosynthesis of natural products
Parent PropertyGenProp0077: natural products biosynthesis
Literature References
[ 1 ]Braun SD, Hofmann J, Wensing A, Ullrich MS, Weingart H, Volksch B, Spiteller D  Identification of the biosynthetic gene cluster for 3-methylarginine, a toxin produced by Pseudomonas syringae pv. syringae 22d/93.  Appl Environ Microbiol. 2010 Apr;76(8):2500-8. doi: 10.1128/AEM.00666-09.  PMID 20190091
[ 2 ]Feng J, Wu J, Gao J, Xia Z, Deng Z, He X  Biosynthesis of beta-Methylarginine residue of Peptidyl Nucleoside Arginomycin in Streptomyces arginensis NRRL 15941.  Appl Environ Microbiol. 2014 Jun 6. pii: AEM.01172-14.  PMID 24907335

Step NameStep NumRequiredEvidence (Method)Evidence Go Terms
2-ketoarginine methyltransferaseMrsAYESTIGR04543 (HMM): 2-ketoarginine methyltransferase
aminotransferase, 3-methylarginine-biosyntheticMrsBYESTIGR04544 (HMM): beta-methylarginine biosynthesis bifunctional aminotransferase

Parent Properties
GenProp0077natural products biosynthesis

Sibling Properties
GenProp0014polyketide biosynthesis, type I
GenProp0015polyketide biosynthesis, type II
GenProp0040thiotemplate type non-ribosomal peptide biosynthesis
GenProp0169hybrid NRPS-PKS natural pruduct biosynthesis genes
GenProp0724phosphonoacetaldehyde biosynthesis from phosphoenolpyruvate
GenProp0757quorum-sensing, autoinducer-2 system
GenProp0758lycopene biosynthesis from IPP
GenProp0770siderophore biosynthesis
GenProp0807bacteriocin system, heterocycle biosynthesis group
GenProp0808bacteriocin system, TIGR01847 leader group
GenProp0809bacteriocin system, lactococcin 972 group
GenProp0823violacein biosynthesis
GenProp0825bacteriocin system, circular bacteriocin group
GenProp0853lantibiotic system, gallidermin/epidermin family
GenProp0861bacteriocin system, NHLP (nif11/nitrile hydratase leader peptide) transport group
GenProp0901post-ribosomal natural product synthesis system, Burkholderia TOMM-type
GenProp0919SCIFF/radical SAM Clostridial gene pair
GenProp0920radical SAM Y_X(10)_GDL system
GenProp0921radical SAM pair and His-Xaa-Ser repeats peptide
GenProp0936bacteriocin system, sporulation delay protein group
GenProp0945radical SAM maturase bacteriocin system, CLI_3235 type
GenProp0954radical SAM-cylized peptide, Pep1357C family
GenProp0955modified peptide/radical SAM maturase system, YydFG family
GenProp0956radical SAM maturase/selenobacteriocin system
GenProp0962methanobactin biosynthesis, Mb-OB3b family
GenProp0967radical SAM maturase system, CXXX repeats type
GenProp0982radical SAM maturase system, FibroRumin system
GenProp0984radical SAM maturase system, GG-Bacteroidales group
GenProp0990cobaltopeptin biosynthesis
GenProp0991ATP-grasp maturase system, microviridin/marinostatin class
GenProp1000ATP-grasp maturase system, uncharacterized
GenProp1002grasp-with-spasm peptide maturase system
GenProp1003cysteine S-glycopeptide biosynthesis, sublancin family
GenProp1029radical SAM/SPASM system SynChlorMet
GenProp1037radical SAM/SPASM system GRRM
GenProp1052geopeptide radical SAM/SPASM maturase system
GenProp1062radical SAM/SPASM system Clo7bot
GenProp1065radical SAM/SPASM TIGR04347/TIGR04031 system
GenProp1078sporulation killing factor system
GenProp1083cyanobactin-like ribosomal natural product biosynthesis
GenProp1084enduracididine biosynthesis
GenProp1090radical SAM/SPASM maturase system XYE
GenProp1097bacimethrin biosynthesis