| Accession | GenProp1084 |
| Name | enduracididine biosynthesis |
| Type | PATHWAY |
| Description | Proteins MppR (homologous to acetoacetate decarboxylases), and MppP and MppQ (both pyridoxal phosphate enzymes related to aminotransferases) are responsible for the biosynthesis of enduracididine, a rare non-proteinogenic amino acid incorporated by some non-ribosomal peptide synthases (NRPS). |
| JCVI Role | Biosynthesis of natural products |
| Parent Property | GenProp0077: natural products biosynthesis
|
| Literature References | [ 1 ]Yin X, Zabriskie TM The enduracidin biosynthetic gene cluster from Streptomyces fungicidicus. Microbiology. 2006 Oct;152(Pt 10):2969-83. PMID 17005978
[ 2 ]Burroughs AM, Hoppe RW, Goebel NC, Sayyed BH, Voegtline TJ, Schwabacher AW, Zabriskie TM, Silvaggi NR Structural and Functional Characterization of MppR, an Enduracididine Biosynthetic Enzyme from Streptomyces hygroscopicus: Functional Diversity in the Acetoacetate Decarboxylase-like Superfamily. Biochemistry. 2013 Jul 2;52(26):4492-506. doi: 10.1021/bi400397k. PMID 23758195
|
|
| Gene Ontology Term | GO:0042398: cellular modified amino acid biosynthetic process (biological_process)
|
| Step Name | Step Num | Required | Evidence (Method) | Evidence Go Terms |
|---|
| enduracididine biosynthesis enzyme MppP | MppP | YES | TIGR04462 (HMM): enduracididine biosynthesis enzyme MppP | GO:0042398: cellular modified amino acid biosynthetic process
|
| enduracididine biosynthesis enzyme MppQ | MppQ | YES | TIGR04461 (HMM): enduracididine biosynthesis enzyme MppQ | GO:0042398: cellular modified amino acid biosynthetic process
|
| enduracididine biosynthesis enzyme MppR | MppR | YES | TIGR04460 (HMM): enduracididine biosynthesis enzyme MppR | GO:0042398: cellular modified amino acid biosynthetic process
|
| Accession | Name |
|---|
| GenProp0014 | polyketide biosynthesis, type I |
| GenProp0015 | polyketide biosynthesis, type II |
| GenProp0040 | thiotemplate type non-ribosomal peptide biosynthesis |
| GenProp0169 | hybrid NRPS-PKS natural pruduct biosynthesis genes |
| GenProp0724 | phosphonoacetaldehyde biosynthesis from phosphoenolpyruvate |
| GenProp0757 | quorum-sensing, autoinducer-2 system |
| GenProp0758 | lycopene biosynthesis from IPP |
| GenProp0770 | siderophore biosynthesis |
| GenProp0807 | bacteriocin system, heterocycle biosynthesis group |
| GenProp0808 | bacteriocin system, TIGR01847 leader group |
| GenProp0809 | bacteriocin system, lactococcin 972 group |
| GenProp0823 | violacein biosynthesis |
| GenProp0825 | bacteriocin system, circular bacteriocin group |
| GenProp0853 | lantibiotic system, gallidermin/epidermin family |
| GenProp0861 | bacteriocin system, NHLP (nif11/nitrile hydratase leader peptide) transport group |
| GenProp0901 | post-ribosomal natural product synthesis system, Burkholderia TOMM-type |
| GenProp0919 | SCIFF/radical SAM Clostridial gene pair |
| GenProp0920 | radical SAM Y_X(10)_GDL system |
| GenProp0921 | radical SAM pair and His-Xaa-Ser repeats peptide |
| GenProp0936 | bacteriocin system, sporulation delay protein group |
| GenProp0945 | radical SAM maturase bacteriocin system, CLI_3235 type |
| GenProp0954 | radical SAM-cylized peptide, Pep1357C family |
| GenProp0955 | modified peptide/radical SAM maturase system, YydFG family |
| GenProp0956 | radical SAM maturase/selenobacteriocin system |
| GenProp0962 | methanobactin biosynthesis, Mb-OB3b family |
| GenProp0967 | radical SAM maturase system, CXXX repeats type |
| GenProp0982 | radical SAM maturase system, FibroRumin system |
| GenProp0984 | radical SAM maturase system, GG-Bacteroidales group |
| GenProp0990 | cobaltopeptin biosynthesis |
| GenProp0991 | ATP-grasp maturase system, microviridin/marinostatin class |
| GenProp1000 | ATP-grasp maturase system, uncharacterized |
| GenProp1002 | grasp-with-spasm peptide maturase system |
| GenProp1003 | cysteine S-glycopeptide biosynthesis, sublancin family |
| GenProp1029 | radical SAM/SPASM system SynChlorMet |
| GenProp1037 | radical SAM/SPASM system GRRM |
| GenProp1052 | geopeptide radical SAM/SPASM maturase system |
| GenProp1062 | radical SAM/SPASM system Clo7bot |
| GenProp1065 | radical SAM/SPASM TIGR04347/TIGR04031 system |
| GenProp1078 | sporulation killing factor system |
| GenProp1083 | cyanobactin-like ribosomal natural product biosynthesis |
| GenProp1090 | radical SAM/SPASM maturase system XYE |
| GenProp1097 | bacimethrin biosynthesis |
| GenProp1098 | 3-methylarginine biosynthesis |
