Genome Property Definition Page
| Accession | GenProp0861 |
| Name | bacteriocin system, NHLP (nif11/nitrile hydratase leader peptide) transport group |
| Type | SYSTEM |
| Description | Model TIGR03793 describes a leader peptide region (homologous to the nitrile hydratase alpha subunit) for peptides subject to modification by bacteriocin-like maturation enzyme clusters, typically including either a cyclodehydratase and a dehydrogenase (producing TOMMS - Thiazole/Oxazole-Modified Microcins) or a lantibiotic synthase. Radical SAM enzymes are commonly found as well. While sequences of the mature peptides are highly variable, as are their modification clusters, the leader peptide region shows a close phylogenetic correlation to a three gene transporter operon, one subunit of which includes a protease domain for cleavage at the Gly-Gly motif at the end of the leader peptide region. This property describes the transport operon as well as the leader peptide family. |
| JCVI Role | Toxin production and resistance |
| Parent Property | GenProp0077: natural products biosynthesis |
| Gene Ontology Term | GO:0043213: bacteriocin transport (biological_process) |
Components
| Step Name | Step Num | Required | Evidence (Method) | Evidence Go Terms |
|---|---|---|---|---|
| bacteriocin, nitrile hydratase-homologous leader family | NHLP | YES | TIGR03793 (HMM): NHLP leader peptide domain TIGR03798 (HMM): nif11-like leader peptide domain | GO:0043213: bacteriocin transport |
| NHLP bacteriocin system ABC transporter, peptidase/ATP-binding protein | NHLP_A | YES | TIGR03797 (HMM): NHLM bacteriocin system ABC transporter, ATP-binding protein | GO:0043213: bacteriocin transport |
| NHLP class bacteriocin export protein, HlyD family | NHLP_H | YES | TIGR03794 (HMM): NHLM bacteriocin system secretion protein | GO:0043213: bacteriocin transport |
| NHLM bacteriocin system ABC transporter, peptidase/ATP-binding protein | NHLP_X | YES | TIGR03796 (HMM): NHLM bacteriocin system ABC transporter, peptidase/ATP-binding protein | GO:0043213: bacteriocin transport |
| NHLP bacteriocin system radical SAM enzyme | NHLP_rS | NO | TIGR03975 (HMM): ribosomal peptide maturation radical SAM protein 1 TIGR04064 (HMM): nif11-like peptide radical SAM maturase | GO:0043213: bacteriocin transport GO:0043213: bacteriocin transport |
Parent Properties
| Accession | Name |
|---|---|
| GenProp0077 | natural products biosynthesis |
Sibling Properties
| Accession | Name |
|---|---|
| GenProp0014 | polyketide biosynthesis, type I |
| GenProp0015 | polyketide biosynthesis, type II |
| GenProp0040 | thiotemplate type non-ribosomal peptide biosynthesis |
| GenProp0169 | hybrid NRPS-PKS natural pruduct biosynthesis genes |
| GenProp0724 | phosphonoacetaldehyde biosynthesis from phosphoenolpyruvate |
| GenProp0757 | quorum-sensing, autoinducer-2 system |
| GenProp0758 | lycopene biosynthesis from IPP |
| GenProp0770 | siderophore biosynthesis |
| GenProp0807 | bacteriocin system, heterocycle biosynthesis group |
| GenProp0808 | bacteriocin system, TIGR01847 leader group |
| GenProp0809 | bacteriocin system, lactococcin 972 group |
| GenProp0823 | violacein biosynthesis |
| GenProp0825 | bacteriocin system, circular bacteriocin group |
| GenProp0853 | lantibiotic system, gallidermin/epidermin family |
| GenProp0901 | post-ribosomal natural product synthesis system, Burkholderia TOMM-type |
| GenProp0919 | SCIFF/radical SAM Clostridial gene pair |
| GenProp0920 | radical SAM Y_X(10)_GDL system |
| GenProp0921 | radical SAM pair and His-Xaa-Ser repeats peptide |
| GenProp0936 | bacteriocin system, sporulation delay protein group |
| GenProp0945 | radical SAM maturase bacteriocin system, CLI_3235 type |
| GenProp0954 | radical SAM-cylized peptide, Pep1357C family |
| GenProp0955 | modified peptide/radical SAM maturase system, YydFG family |
| GenProp0956 | radical SAM maturase/selenobacteriocin system |
| GenProp0962 | methanobactin biosynthesis, Mb-OB3b family |
| GenProp0967 | radical SAM maturase system, CXXX repeats type |
| GenProp0982 | radical SAM maturase system, FibroRumin system |
| GenProp0984 | radical SAM maturase system, GG-Bacteroidales group |
| GenProp0990 | cobaltopeptin biosynthesis |
| GenProp0991 | ATP-grasp maturase system, microviridin/marinostatin class |
| GenProp1000 | ATP-grasp maturase system, uncharacterized |
| GenProp1002 | grasp-with-spasm peptide maturase system |
| GenProp1003 | cysteine S-glycopeptide biosynthesis, sublancin family |
| GenProp1029 | radical SAM/SPASM system SynChlorMet |
| GenProp1037 | radical SAM/SPASM system GRRM |
| GenProp1052 | geopeptide radical SAM/SPASM maturase system |
| GenProp1062 | radical SAM/SPASM system Clo7bot |
| GenProp1065 | radical SAM/SPASM TIGR04347/TIGR04031 system |
| GenProp1078 | sporulation killing factor system |
| GenProp1083 | cyanobactin-like ribosomal natural product biosynthesis |
| GenProp1084 | enduracididine biosynthesis |
| GenProp1090 | radical SAM/SPASM maturase system XYE |
| GenProp1097 | bacimethrin biosynthesis |
| GenProp1098 | 3-methylarginine biosynthesis |