Genome Property Definition Page

Namebacteriocin system, NHLP (nif11/nitrile hydratase leader peptide) transport group
DescriptionModel TIGR03793 describes a leader peptide region (homologous to the nitrile hydratase alpha subunit) for peptides subject to modification by bacteriocin-like maturation enzyme clusters, typically including either a cyclodehydratase and a dehydrogenase (producing TOMMS - Thiazole/Oxazole-Modified Microcins) or a lantibiotic synthase. Radical SAM enzymes are commonly found as well. While sequences of the mature peptides are highly variable, as are their modification clusters, the leader peptide region shows a close phylogenetic correlation to a three gene transporter operon, one subunit of which includes a protease domain for cleavage at the Gly-Gly motif at the end of the leader peptide region. This property describes the transport operon as well as the leader peptide family.
JCVI RoleToxin production and resistance
Parent PropertyGenProp0077: natural products biosynthesis
Gene Ontology TermGO:0043213: bacteriocin transport (biological_process)

Step NameStep NumRequiredEvidence (Method)Evidence Go Terms
bacteriocin, nitrile hydratase-homologous leader familyNHLPYESTIGR03793 (HMM): NHLP leader peptide domain
TIGR03798 (HMM): nif11-like leader peptide domain
GO:0043213: bacteriocin transport
NHLP bacteriocin system ABC transporter, peptidase/ATP-binding proteinNHLP_AYESTIGR03797 (HMM): NHLM bacteriocin system ABC transporter, ATP-binding proteinGO:0043213: bacteriocin transport
NHLP class bacteriocin export protein, HlyD familyNHLP_HYESTIGR03794 (HMM): NHLM bacteriocin system secretion proteinGO:0043213: bacteriocin transport
NHLM bacteriocin system ABC transporter, peptidase/ATP-binding proteinNHLP_XYESTIGR03796 (HMM): NHLM bacteriocin system ABC transporter, peptidase/ATP-binding proteinGO:0043213: bacteriocin transport
NHLP bacteriocin system radical SAM enzymeNHLP_rSNOTIGR03975 (HMM): ribosomal peptide maturation radical SAM protein 1
TIGR04064 (HMM): nif11-like peptide radical SAM maturase
GO:0043213: bacteriocin transport
GO:0043213: bacteriocin transport

Parent Properties
GenProp0077natural products biosynthesis

Sibling Properties
GenProp0014polyketide biosynthesis, type I
GenProp0015polyketide biosynthesis, type II
GenProp0040thiotemplate type non-ribosomal peptide biosynthesis
GenProp0169hybrid NRPS-PKS natural pruduct biosynthesis genes
GenProp0724phosphonoacetaldehyde biosynthesis from phosphoenolpyruvate
GenProp0757quorum-sensing, autoinducer-2 system
GenProp0758lycopene biosynthesis from IPP
GenProp0770siderophore biosynthesis
GenProp0807bacteriocin system, heterocycle biosynthesis group
GenProp0808bacteriocin system, TIGR01847 leader group
GenProp0809bacteriocin system, lactococcin 972 group
GenProp0823violacein biosynthesis
GenProp0825bacteriocin system, circular bacteriocin group
GenProp0853lantibiotic system, gallidermin/epidermin family
GenProp0901post-ribosomal natural product synthesis system, Burkholderia TOMM-type
GenProp0919SCIFF/radical SAM Clostridial gene pair
GenProp0920radical SAM Y_X(10)_GDL system
GenProp0921radical SAM pair and His-Xaa-Ser repeats peptide
GenProp0936bacteriocin system, sporulation delay protein group
GenProp0945radical SAM maturase bacteriocin system, CLI_3235 type
GenProp0954radical SAM-cylized peptide, Pep1357C family
GenProp0955modified peptide/radical SAM maturase system, YydFG family
GenProp0956radical SAM maturase/selenobacteriocin system
GenProp0962methanobactin biosynthesis, Mb-OB3b family
GenProp0967radical SAM maturase system, CXXX repeats type
GenProp0982radical SAM maturase system, FibroRumin system
GenProp0984radical SAM maturase system, GG-Bacteroidales group
GenProp0990cobaltopeptin biosynthesis
GenProp0991ATP-grasp maturase system, microviridin/marinostatin class
GenProp1000ATP-grasp maturase system, uncharacterized
GenProp1002grasp-with-spasm peptide maturase system
GenProp1003cysteine S-glycopeptide biosynthesis, sublancin family
GenProp1029radical SAM/SPASM system SynChlorMet
GenProp1037radical SAM/SPASM system GRRM
GenProp1052geopeptide radical SAM/SPASM maturase system
GenProp1062radical SAM/SPASM system Clo7bot
GenProp1065radical SAM/SPASM TIGR04347/TIGR04031 system
GenProp1078sporulation killing factor system
GenProp1083cyanobactin-like ribosomal natural product biosynthesis
GenProp1084enduracididine biosynthesis
GenProp1090radical SAM/SPASM maturase system XYE
GenProp1097bacimethrin biosynthesis
GenProp10983-methylarginine biosynthesis