Genome Property Definition Page

Namepolyketide biosynthesis, type I
DescriptionAllowed states: YES NO Polyketides are an important class of natural product which are assembled by the sequential addition of units containing at minimum one acetate group. Polyketides include many antibiotics and other compounds of biological and economic importance. Polyketides may be synthesized by large multi-domain proteins (Type I polyketide synthetases) which carry out a so-called thio-template program in which successive modules of domains add single units to the growing end of the polyketide chain, modify the newly added piece (usually a series of reductions) and pass the chain on to the next module. The overall mechanism is similar to that observed in the biosynthesis of fatty acids in animals via the Type I fatty acid synthases. By contrast, Type II polyketide synthetases, which are similar to the Type II fatty acid synthases found in bacteria and plants, consist of separate proteins for each of the various functions involved in the overall process. Plant chalcones and stilbenes are synthesized by yet a third style of synthetase in which a single condensing enzyme is active for all condensation steps. Many of the constituent domains of type I polyketide synthetases have been defined by HMM models. These include acyl transferase (PF00698), beta-ketoacyl-synthase (PF00109, PF02801), acyl carrier protein (PF00550) and thioesterase (PF00975) domains. Other commonly found domains which have not yet been represented by HMMs include ketoreductase, dehydratase and enoyl reductase domains. This genome property will be set to YES if any single gene in the genome contains domains corresponding to PF00698, PF00109, PF02801 and PF00550. (These correspond to the minimum set of domains for production of a polyketide chain.) Failing that condition, a YES will be set if two consecutive genes in combination contain all of these domains (as type I polyketide synthetases are sometimes found as multiple genes broken up between some, but not all, of the domains). Otherwise, the propery will be set to NO. A NULL value indicates that the genome has not yet been evaluated with regard to this property.
JCVI RoleBiosynthesis of natural products
Parent PropertyGenProp0077: natural products biosynthesis
Gene Ontology TermGO:0030639: polyketide biosynthetic process (biological_process)

Step NameStep NumRequiredEvidence (Method)Evidence Go Terms
acyl trans, keto synth and thioest domains in the same ORFAT+KS+TEYESPF00698 + PF00109 + PF02801 + (RULES): GO:0030639: polyketide biosynthetic process

Parent Properties
GenProp0077natural products biosynthesis

Sibling Properties
GenProp0015polyketide biosynthesis, type II
GenProp0040thiotemplate type non-ribosomal peptide biosynthesis
GenProp0169hybrid NRPS-PKS natural pruduct biosynthesis genes
GenProp0724phosphonoacetaldehyde biosynthesis from phosphoenolpyruvate
GenProp0757quorum-sensing, autoinducer-2 system
GenProp0758lycopene biosynthesis from IPP
GenProp0770siderophore biosynthesis
GenProp0807bacteriocin system, heterocycle biosynthesis group
GenProp0808bacteriocin system, TIGR01847 leader group
GenProp0809bacteriocin system, lactococcin 972 group
GenProp0823violacein biosynthesis
GenProp0825bacteriocin system, circular bacteriocin group
GenProp0853lantibiotic system, gallidermin/epidermin family
GenProp0861bacteriocin system, NHLP (nif11/nitrile hydratase leader peptide) transport group
GenProp0901post-ribosomal natural product synthesis system, Burkholderia TOMM-type
GenProp0919SCIFF/radical SAM Clostridial gene pair
GenProp0920radical SAM Y_X(10)_GDL system
GenProp0921radical SAM pair and His-Xaa-Ser repeats peptide
GenProp0936bacteriocin system, sporulation delay protein group
GenProp0945radical SAM maturase bacteriocin system, CLI_3235 type
GenProp0954radical SAM-cylized peptide, Pep1357C family
GenProp0955modified peptide/radical SAM maturase system, YydFG family
GenProp0956radical SAM maturase/selenobacteriocin system
GenProp0962methanobactin biosynthesis, Mb-OB3b family
GenProp0967radical SAM maturase system, CXXX repeats type
GenProp0982radical SAM maturase system, FibroRumin system
GenProp0984radical SAM maturase system, GG-Bacteroidales group
GenProp0990cobaltopeptin biosynthesis
GenProp0991ATP-grasp maturase system, microviridin/marinostatin class
GenProp1000ATP-grasp maturase system, uncharacterized
GenProp1002grasp-with-spasm peptide maturase system
GenProp1003cysteine S-glycopeptide biosynthesis, sublancin family
GenProp1029radical SAM/SPASM system SynChlorMet
GenProp1037radical SAM/SPASM system GRRM
GenProp1052geopeptide radical SAM/SPASM maturase system
GenProp1062radical SAM/SPASM system Clo7bot
GenProp1065radical SAM/SPASM TIGR04347/TIGR04031 system
GenProp1078sporulation killing factor system
GenProp1083cyanobactin-like ribosomal natural product biosynthesis
GenProp1084enduracididine biosynthesis
GenProp1090radical SAM/SPASM maturase system XYE
GenProp1097bacimethrin biosynthesis
GenProp10983-methylarginine biosynthesis