| Accession | GenProp1029 |
| Name | radical SAM/SPASM system SynChlorMet |
| Type | SYSTEM |
| Description | This property features a four-gene cassette that appears to be involved in peptide modification. The system has both a PqqD homolog and two PqqE homologs. The predicted fifth component, putative modification target ScmA, is not identified, but Clim_1912 (YP_001943923.1) from Chlorobium limicola DSM 245 is suggested; homologous ORFs are demonstrated in the cassettes of the other species with the cassette, and their alignment modeled by TIGR04252. Three other species with the cassette are Syntrophobacter fumaroxidans MPOB, Methanocella paludicola SANAE, and delta proteobacterium NaphS2. Regions homologous to Clim_1912 are found in the other three species, and conservation at the amino acid level appears strongest in the reading frame of Clim_1912. The SPASM domain involvement in peptide modification is described in PMID:21478363. |
| Parent Property | GenProp0077: natural products biosynthesis
|
| Literature References | [ 1 ]Haft DH, Basu MK Biological systems discovery in silico: radical S-adenosylmethionine protein families and their target peptides for posttranslational modification. J Bacteriol. 2011 Jun;193(11):2745-55. PMID 21478363
|
|
| Step Name | Step Num | Required | Evidence (Method) | Evidence Go Terms |
|---|
| putative SynChlorMet system core peptide | ScmA | NO | TIGR04252 (HMM): SynChlorMet cassette protein ScmA | |
| SynChlorMet cassette protein ScmC | ScmC | YES | TIGR04249 (HMM): SynChlorMet cassette protein ScmC | |
| SynChlorMet cassette protein ScmD | ScmD | YES | TIGR04248 (HMM): SynChlorMet cassette protein ScmD | |
| SynChlorMet cassette radical SAM/SPASM protein ScmE | ScmE | YES | TIGR04250 (HMM): SynChlorMet cassette radical SAM/SPASM protein ScmE | |
| SynChlorMet cassette radical SAM/SPASM protein ScmF | ScmF | YES | TIGR04251 (HMM): SynChlorMet cassette radical SAM/SPASM protein ScmF | |
| Accession | Name |
|---|
| GenProp0014 | polyketide biosynthesis, type I |
| GenProp0015 | polyketide biosynthesis, type II |
| GenProp0040 | thiotemplate type non-ribosomal peptide biosynthesis |
| GenProp0169 | hybrid NRPS-PKS natural pruduct biosynthesis genes |
| GenProp0724 | phosphonoacetaldehyde biosynthesis from phosphoenolpyruvate |
| GenProp0757 | quorum-sensing, autoinducer-2 system |
| GenProp0758 | lycopene biosynthesis from IPP |
| GenProp0770 | siderophore biosynthesis |
| GenProp0807 | bacteriocin system, heterocycle biosynthesis group |
| GenProp0808 | bacteriocin system, TIGR01847 leader group |
| GenProp0809 | bacteriocin system, lactococcin 972 group |
| GenProp0823 | violacein biosynthesis |
| GenProp0825 | bacteriocin system, circular bacteriocin group |
| GenProp0853 | lantibiotic system, gallidermin/epidermin family |
| GenProp0861 | bacteriocin system, NHLP (nif11/nitrile hydratase leader peptide) transport group |
| GenProp0901 | post-ribosomal natural product synthesis system, Burkholderia TOMM-type |
| GenProp0919 | SCIFF/radical SAM Clostridial gene pair |
| GenProp0920 | radical SAM Y_X(10)_GDL system |
| GenProp0921 | radical SAM pair and His-Xaa-Ser repeats peptide |
| GenProp0936 | bacteriocin system, sporulation delay protein group |
| GenProp0945 | radical SAM maturase bacteriocin system, CLI_3235 type |
| GenProp0954 | radical SAM-cylized peptide, Pep1357C family |
| GenProp0955 | modified peptide/radical SAM maturase system, YydFG family |
| GenProp0956 | radical SAM maturase/selenobacteriocin system |
| GenProp0962 | methanobactin biosynthesis, Mb-OB3b family |
| GenProp0967 | radical SAM maturase system, CXXX repeats type |
| GenProp0982 | radical SAM maturase system, FibroRumin system |
| GenProp0984 | radical SAM maturase system, GG-Bacteroidales group |
| GenProp0990 | cobaltopeptin biosynthesis |
| GenProp0991 | ATP-grasp maturase system, microviridin/marinostatin class |
| GenProp1000 | ATP-grasp maturase system, uncharacterized |
| GenProp1002 | grasp-with-spasm peptide maturase system |
| GenProp1003 | cysteine S-glycopeptide biosynthesis, sublancin family |
| GenProp1037 | radical SAM/SPASM system GRRM |
| GenProp1052 | geopeptide radical SAM/SPASM maturase system |
| GenProp1062 | radical SAM/SPASM system Clo7bot |
| GenProp1065 | radical SAM/SPASM TIGR04347/TIGR04031 system |
| GenProp1078 | sporulation killing factor system |
| GenProp1083 | cyanobactin-like ribosomal natural product biosynthesis |
| GenProp1084 | enduracididine biosynthesis |
| GenProp1090 | radical SAM/SPASM maturase system XYE |
| GenProp1097 | bacimethrin biosynthesis |
| GenProp1098 | 3-methylarginine biosynthesis |
