| Accession | GenProp0984 |
| Name | radical SAM maturase system, GG-Bacteroidales group |
| Type | SYSTEM |
| Description | This Genome Property is one of many in which a ribosomally translated peptide is modified post-translationally. Many of the natural products generated are bacteriocins, although bacteriocin activity cannot be presumed. An odd feature of this system is the pairing of a radical SAM enzyme (TIGR04148) with a degenerate radical SAM (pseudo-SAM) protein (TIGR04150). In family TIGR04150, despite full-length homology, some members have but other lack the radical SAM signature 4Fe4S-binding site. All members, however, are best conserved at the C-terminus, where the signature motif for the SPASM domain (as in Subtilosin, PQQ, Anaearobic Sulfatase and Mycofactocin maturases) homology 4Fe4S binding site (see TIGR04085) is invariant. This system occurs, so far, only in the Bacteroidales. |
| Parent Property | GenProp0077: natural products biosynthesis
|
| Literature References | [ 1 ]Haft DH, Basu MK Biological systems discovery in silico: radical s-adenosylmethionine protein families and their target peptides for posttranslational modification. J Bacteriol. 2011 Jun;193(11):2745-55. PMID 21478363
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| Step Name | Step Num | Required | Evidence (Method) | Evidence Go Terms |
|---|
| glycosyltransferase, GG-Bacteroidales peptide system | CFB_gly | YES | TIGR04157 (HMM): glycosyltransferase, GG-Bacteroidales peptide system | |
| peptide-modifying radical SAM enzyme, GG-Bacteroidales family | CFB_mod | YES | TIGR04148 (HMM): radical SAM peptide maturase, GG-Bacteroidales family | |
| natural product precursor, GG-Bacteroidales family | CFB_pep | YES | TIGR04149 (HMM): natural product precursor, GG-Bacteroidales family | |
| pseudo-rSAM protein, GG-Bacteroidales system | CFB_pse | YES | TIGR04150 (HMM): pseudo-rSAM protein, GG-Bacteroidales system | |
| Accession | Name |
|---|
| GenProp0014 | polyketide biosynthesis, type I |
| GenProp0015 | polyketide biosynthesis, type II |
| GenProp0040 | thiotemplate type non-ribosomal peptide biosynthesis |
| GenProp0169 | hybrid NRPS-PKS natural pruduct biosynthesis genes |
| GenProp0724 | phosphonoacetaldehyde biosynthesis from phosphoenolpyruvate |
| GenProp0757 | quorum-sensing, autoinducer-2 system |
| GenProp0758 | lycopene biosynthesis from IPP |
| GenProp0770 | siderophore biosynthesis |
| GenProp0807 | bacteriocin system, heterocycle biosynthesis group |
| GenProp0808 | bacteriocin system, TIGR01847 leader group |
| GenProp0809 | bacteriocin system, lactococcin 972 group |
| GenProp0823 | violacein biosynthesis |
| GenProp0825 | bacteriocin system, circular bacteriocin group |
| GenProp0853 | lantibiotic system, gallidermin/epidermin family |
| GenProp0861 | bacteriocin system, NHLP (nif11/nitrile hydratase leader peptide) transport group |
| GenProp0901 | post-ribosomal natural product synthesis system, Burkholderia TOMM-type |
| GenProp0919 | SCIFF/radical SAM Clostridial gene pair |
| GenProp0920 | radical SAM Y_X(10)_GDL system |
| GenProp0921 | radical SAM pair and His-Xaa-Ser repeats peptide |
| GenProp0936 | bacteriocin system, sporulation delay protein group |
| GenProp0945 | radical SAM maturase bacteriocin system, CLI_3235 type |
| GenProp0954 | radical SAM-cylized peptide, Pep1357C family |
| GenProp0955 | modified peptide/radical SAM maturase system, YydFG family |
| GenProp0956 | radical SAM maturase/selenobacteriocin system |
| GenProp0962 | methanobactin biosynthesis, Mb-OB3b family |
| GenProp0967 | radical SAM maturase system, CXXX repeats type |
| GenProp0982 | radical SAM maturase system, FibroRumin system |
| GenProp0990 | cobaltopeptin biosynthesis |
| GenProp0991 | ATP-grasp maturase system, microviridin/marinostatin class |
| GenProp1000 | ATP-grasp maturase system, uncharacterized |
| GenProp1002 | grasp-with-spasm peptide maturase system |
| GenProp1003 | cysteine S-glycopeptide biosynthesis, sublancin family |
| GenProp1029 | radical SAM/SPASM system SynChlorMet |
| GenProp1037 | radical SAM/SPASM system GRRM |
| GenProp1052 | geopeptide radical SAM/SPASM maturase system |
| GenProp1062 | radical SAM/SPASM system Clo7bot |
| GenProp1065 | radical SAM/SPASM TIGR04347/TIGR04031 system |
| GenProp1078 | sporulation killing factor system |
| GenProp1083 | cyanobactin-like ribosomal natural product biosynthesis |
| GenProp1084 | enduracididine biosynthesis |
| GenProp1090 | radical SAM/SPASM maturase system XYE |
| GenProp1097 | bacimethrin biosynthesis |
| GenProp1098 | 3-methylarginine biosynthesis |
