Genome Property Definition Page

Namebacteriocin system, heterocycle biosynthesis group
DescriptionThis Genome Property is a working space for the guild of bacteriocin production, focusing on heterocycle-containing in the style of the SagA system of S. pyogenes. Sets of proteins performing various chemistries sit nearby, most failing to form cliques among related proteins that could serve as markers. However, some narrow-scope, high-precision search models (HMM or BrainGrab) will make strong identifications on some components. See the article "Discovery of a widely distributed toxin biosynthetic gene cluster.", PMID: 18375757
JCVI RoleToxin production and resistance
Parent PropertyGenProp0077: natural products biosynthesis
Literature References
[ 1 ] Lee SW, Mitchell DA, Markley AL, Hensler ME, Gonzalez D, Wohlrab A, Dorrestein PC, Nizet V, Dixon JE   Discovery of a widely distributed toxin biosynthetic gene cluster.   Proc Natl Acad Sci U S A. 2008 Apr 15;105(15):5879-84.  PMID 18375757
[ 2 ]Dunbar KL, Melby JO, Mitchell DA  YcaO domains use ATP to activate amide backbones during peptide cyclodehydrations.  Nat Chem Biol. 2012 Apr 22;8(6):569-75.  PMID 22522320

Step NameStep NumRequiredEvidence (Method)Evidence Go Terms
cyclodehydratase(SagC)cyclodeYESTIGR03603 (HMM): thiazole/oxazole-forming peptide maturase, SagC family component
2374 (RULE_BASE)

TIGR03882 (HMM): bacteriocin biosynthesis cyclodehydratase domain
SagB-type dehydrogenase domaindehydYESTIGR03605 (HMM): SagB-type dehydrogenase domain
docking scaffold proteindockingYESTIGR03604 (HMM): thiazole/oxazole-forming peptide maturase, SagD family component
heterocyclic bacteriocin protoxinprotoxYESTIGR03601 (HMM): bacteriocin, heterocycloanthracin/sonorensin family
TIGR03602 (HMM): bacteriocin protoxin, streptolysin S family
TIGR03678 (HMM): bacteriocin leader peptide, microcyclamide/patellamide family
TIGR03793 (HMM): NHLP leader peptide domain
TIGR03798 (HMM): nif11-like leader peptide domain
TIGR03892 (HMM): thiazolylpeptide-type bacteriocin precursor

Parent Properties
GenProp0077natural products biosynthesis

Sibling Properties
GenProp0014polyketide biosynthesis, type I
GenProp0015polyketide biosynthesis, type II
GenProp0040thiotemplate type non-ribosomal peptide biosynthesis
GenProp0169hybrid NRPS-PKS natural pruduct biosynthesis genes
GenProp0724phosphonoacetaldehyde biosynthesis from phosphoenolpyruvate
GenProp0757quorum-sensing, autoinducer-2 system
GenProp0758lycopene biosynthesis from IPP
GenProp0770siderophore biosynthesis
GenProp0808bacteriocin system, TIGR01847 leader group
GenProp0809bacteriocin system, lactococcin 972 group
GenProp0823violacein biosynthesis
GenProp0825bacteriocin system, circular bacteriocin group
GenProp0853lantibiotic system, gallidermin/epidermin family
GenProp0861bacteriocin system, NHLP (nif11/nitrile hydratase leader peptide) transport group
GenProp0901post-ribosomal natural product synthesis system, Burkholderia TOMM-type
GenProp0919SCIFF/radical SAM Clostridial gene pair
GenProp0920radical SAM Y_X(10)_GDL system
GenProp0921radical SAM pair and His-Xaa-Ser repeats peptide
GenProp0936bacteriocin system, sporulation delay protein group
GenProp0945radical SAM maturase bacteriocin system, CLI_3235 type
GenProp0954radical SAM-cylized peptide, Pep1357C family
GenProp0955modified peptide/radical SAM maturase system, YydFG family
GenProp0956radical SAM maturase/selenobacteriocin system
GenProp0962methanobactin biosynthesis, Mb-OB3b family
GenProp0967radical SAM maturase system, CXXX repeats type
GenProp0982radical SAM maturase system, FibroRumin system
GenProp0984radical SAM maturase system, GG-Bacteroidales group
GenProp0990cobaltopeptin biosynthesis
GenProp0991ATP-grasp maturase system, microviridin/marinostatin class
GenProp1000ATP-grasp maturase system, uncharacterized
GenProp1002grasp-with-spasm peptide maturase system
GenProp1003cysteine S-glycopeptide biosynthesis, sublancin family
GenProp1029radical SAM/SPASM system SynChlorMet
GenProp1037radical SAM/SPASM system GRRM
GenProp1052geopeptide radical SAM/SPASM maturase system
GenProp1062radical SAM/SPASM system Clo7bot
GenProp1065radical SAM/SPASM TIGR04347/TIGR04031 system
GenProp1078sporulation killing factor system
GenProp1083cyanobactin-like ribosomal natural product biosynthesis
GenProp1084enduracididine biosynthesis
GenProp1090radical SAM/SPASM maturase system XYE
GenProp1097bacimethrin biosynthesis
GenProp10983-methylarginine biosynthesis