| Accession | GenProp0793 |
| Name | CMP-N-acetylneuraminate biosynthesis from UDP-N-acetylglucosamine |
| Type | METAPATH |
| Description | CMP-N5-acetylneuraminate (CMP-Neu5Ac) is the activated version of a sugar unit found in certain glycolipids and glycoproteins. Neuraminic acid is also commonly known as sialic acid. In particular, Neu5Ac is observed in certain versions of the E. coli O-antigen [1]. CMP-Neu5Ac is synthesized in three steps: isomerization of UDP-GlcNAc to N-Acetyl-D-Mannosamine (ManNAc) catalyzed by NeuC (5.1.3.14), a condensation with phosphoenolpyruvate to form NeuNAc catalyzed by NeuB (2.5.1.56) and an activation with CTPcatalyzed by NeuA (2.7.7.43). A fourth gene product, NeuD is believed to carry out O-acetyltransfers onto sialic acid but is often missing and is also found more broadly than NeuABC |
| Parent Property | GenProp0186: storage and structural polymer biosynthesis
GenProp0795: carbohydrate biosynthesis
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| Literature References | [ 1 ] Feng L, Senchenkova SN, Tao J, Shashkov AS, Liu B, Shevelev SD, Reeves PR, Xu J, Knirel YA, Wang L Structural and genetic characterization of enterohemorrhagic Escherichia coli O145 O antigen and development of an O145 serogroup-specific PCR assay. J Bacteriol. 2005 Jan;187(2):758-64. PMID 15629947
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| Web References | KEGG:Aminosugars Metabolism
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| Gene Ontology Term | GO:0006054: N-acetylneuraminate metabolic process (biological_process)
|
| Step Name | Step Num | Required | Evidence (Method) | Evidence Go Terms |
|---|
| CTP:N-acylneuraminate cytidyltransferase (2.7.7.43) | NeuA | YES | PF02348 (HMM-CLUST): cytidylyltransferase | GO:0006054: N-acetylneuraminate metabolic process
|
| N-acetylneuraminate synthase (2.5.1.56) | NeuB | YES | TIGR03569 (HMM): N-acetylneuraminate synthase | GO:0006054: N-acetylneuraminate metabolic process
|
| UDP-N-acetyl-D-glucosamine 2-epimerase, UDP-hydrolysing | NeuC | YES | TIGR03568 (HMM): UDP-N-acetyl-D-glucosamine 2-epimerase, UDP-hydrolysing | GO:0006054: N-acetylneuraminate metabolic process
|
| sialic acid O-acetyltransferase NeuD | NeuD | NO | TIGR03570 (HMM-CLUST): sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family | GO:0006054: N-acetylneuraminate metabolic process
|
| source of UDP-N-acetyl-D-glucosamine | UGlcNAc | NO | GenProp0750 (GENPROP): UDP-N-acetylglucosamine biosynthesis from fructose-6-phosphate
| GO:0006054: N-acetylneuraminate metabolic process
|
| Accession | Name |
|---|
| GenProp0055 | polyhydroxyalkanoic acids |
| GenProp0156 | cyanophycin-like storage polymers |
| GenProp0158 | peptidoglycan(murein) biosynthesis |
| GenProp0168 | glycogen system |
| GenProp0183 | dTDP-L-rhamnose biosynthesis from dTDP-4-dehydro-L-rhamnose |
| GenProp0297 | lipopolysaccharide biosynthesis |
| GenProp0652 | exopolysaccharide biosynthesis, exosortase A-associated |
| GenProp0655 | exopolysaccharide biosynthesis, exosortase B-associated |
| GenProp0658 | cellulose biosynthesis |
| GenProp0822 | poly(gamma-glutamic acid) biosynthesis |
| GenProp0906 | poly-beta-1,6 N-acetyl-D-glucosamine system, IcaADBC type |
| GenProp0907 | poly-beta-1,6 N-acetyl-D-glucosamine system, PgaABCD type |
| GenProp0264 | glucosylglycerol biosynthesis |
| GenProp0750 | UDP-N-acetylglucosamine biosynthesis from fructose-6-phosphate |
| GenProp0766 | anhydro-N-acetylmuramic acid to N-acetylglucosamine-phosphate |
| GenProp0794 | proposed N-acetyl sugar amidation module WbuXYZ |
| GenProp0796 | CMP-pseudaminic acid biosynthesis from UDP-N-acetylglucosamine |
| GenProp0811 | S-layer homology domain-mediated cell wall binding |
