Genome Property Definition Page

NameCMP-N-acetylneuraminate biosynthesis from UDP-N-acetylglucosamine
DescriptionCMP-N5-acetylneuraminate (CMP-Neu5Ac) is the activated version of a sugar unit found in certain glycolipids and glycoproteins. Neuraminic acid is also commonly known as sialic acid. In particular, Neu5Ac is observed in certain versions of the E. coli O-antigen [1]. CMP-Neu5Ac is synthesized in three steps: isomerization of UDP-GlcNAc to N-Acetyl-D-Mannosamine (ManNAc) catalyzed by NeuC (, a condensation with phosphoenolpyruvate to form NeuNAc catalyzed by NeuB ( and an activation with CTPcatalyzed by NeuA ( A fourth gene product, NeuD is believed to carry out O-acetyltransfers onto sialic acid but is often missing and is also found more broadly than NeuABC
Parent PropertyGenProp0186: storage and structural polymer biosynthesis
GenProp0795: carbohydrate biosynthesis
Literature References
[ 1 ] Feng L, Senchenkova SN, Tao J, Shashkov AS, Liu B, Shevelev SD, Reeves PR, Xu J, Knirel YA, Wang L   Structural and genetic characterization of enterohemorrhagic Escherichia coli O145 O antigen and development of an O145 serogroup-specific PCR assay.   J Bacteriol. 2005 Jan;187(2):758-64.  PMID 15629947
Web ReferencesKEGG:Aminosugars Metabolism
Gene Ontology TermGO:0006054: N-acetylneuraminate metabolic process (biological_process)

Step NameStep NumRequiredEvidence (Method)Evidence Go Terms
CTP:N-acylneuraminate cytidyltransferase ( (HMM-CLUST): cytidylyltransferaseGO:0006054: N-acetylneuraminate metabolic process
N-acetylneuraminate synthase ( (HMM): N-acetylneuraminate synthaseGO:0006054: N-acetylneuraminate metabolic process
UDP-N-acetyl-D-glucosamine 2-epimerase, UDP-hydrolysingNeuCYESTIGR03568 (HMM): UDP-N-acetyl-D-glucosamine 2-epimerase, UDP-hydrolysingGO:0006054: N-acetylneuraminate metabolic process
sialic acid O-acetyltransferase NeuDNeuDNOTIGR03570 (HMM-CLUST): sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD familyGO:0006054: N-acetylneuraminate metabolic process
source of UDP-N-acetyl-D-glucosamineUGlcNAcNOGenProp0750 (GENPROP): UDP-N-acetylglucosamine biosynthesis from fructose-6-phosphate
GO:0006054: N-acetylneuraminate metabolic process

Parent Properties
GenProp0186storage and structural polymer biosynthesis
GenProp0795carbohydrate biosynthesis

Sibling Properties
GenProp0055polyhydroxyalkanoic acids
GenProp0156cyanophycin-like storage polymers
GenProp0158peptidoglycan(murein) biosynthesis
GenProp0168glycogen system
GenProp0183dTDP-L-rhamnose biosynthesis from dTDP-4-dehydro-L-rhamnose
GenProp0297lipopolysaccharide biosynthesis
GenProp0652exopolysaccharide biosynthesis, exosortase A-associated
GenProp0655exopolysaccharide biosynthesis, exosortase B-associated
GenProp0658cellulose biosynthesis
GenProp0822poly(gamma-glutamic acid) biosynthesis
GenProp0906poly-beta-1,6 N-acetyl-D-glucosamine system, IcaADBC type
GenProp0907poly-beta-1,6 N-acetyl-D-glucosamine system, PgaABCD type
GenProp0264glucosylglycerol biosynthesis
GenProp0750UDP-N-acetylglucosamine biosynthesis from fructose-6-phosphate
GenProp0766anhydro-N-acetylmuramic acid to N-acetylglucosamine-phosphate
GenProp0794proposed N-acetyl sugar amidation module WbuXYZ
GenProp0796CMP-pseudaminic acid biosynthesis from UDP-N-acetylglucosamine
GenProp0811S-layer homology domain-mediated cell wall binding