Genome Property Definition Page
| Accession | GenProp0750 | |
| Name | UDP-N-acetylglucosamine biosynthesis from fructose-6-phosphate | |
| Type | PATHWAY | |
| Description | This pathway converts fructose-6-phosphate in four steps to activated N-acetylglucosamine. GlmS produces glucosamine-6-phosphate. GlmM isomerizes this product to glucosamine-1-phosphate. GlmU, which is bifunctional, adds an acetyl group from acetyl-CoA, then acts as N-acetylglucosamine-1-phosphate uridylyltransferase. The product, UDP-N-acetyl-D-glucosamine, is then used both for murein biosynthesis and (in species with LPS) for lipopolysaccharide biosynthesis. | |
| JCVI Role | Biosynthesis and degradation of murein sacculus and peptidoglycan | |
| Parent Property | GenProp0795: carbohydrate biosynthesis | |
| Literature References |
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Components
| Step Name | Step Num | Required | Evidence (Method) | Evidence Go Terms |
|---|---|---|---|---|
| phosphoglucosamine mutase | glmM | YES | TIGR01455 (HMM): phosphoglucosamine mutase TIGR03990 (HMM): phosphoglucosamine mutase | |
| glutamine--fructose-6-phosphate transaminase (isomerizing) | glmS | YES | TIGR01135 (HMM): glutamine-fructose-6-phosphate transaminase (isomerizing) | |
| glucosamine-1-phosphate N-acetyltransferase/UDP-N-acetylglucosamine diphosphorylase | glmU | YES | TIGR01173 (HMM): UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase TIGR03991 (HMM): UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase |
Parent Properties
| Accession | Name |
|---|---|
| GenProp0795 | carbohydrate biosynthesis |
Sibling Properties
| Accession | Name |
|---|---|
| GenProp0183 | dTDP-L-rhamnose biosynthesis from dTDP-4-dehydro-L-rhamnose |
| GenProp0264 | glucosylglycerol biosynthesis |
| GenProp0297 | lipopolysaccharide biosynthesis |
| GenProp0766 | anhydro-N-acetylmuramic acid to N-acetylglucosamine-phosphate |
| GenProp0793 | CMP-N-acetylneuraminate biosynthesis from UDP-N-acetylglucosamine |
| GenProp0794 | proposed N-acetyl sugar amidation module WbuXYZ |
| GenProp0796 | CMP-pseudaminic acid biosynthesis from UDP-N-acetylglucosamine |
| GenProp0811 | S-layer homology domain-mediated cell wall binding |