| Accession | GenProp0906 |
| Name | poly-beta-1,6 N-acetyl-D-glucosamine system, IcaADBC type |
| Type | SYSTEM |
| Description | Many pathogenic bacteria produce an exopolysaccharide based on poly-N-acetylglucosamine. It is an important factor in biofilm formation and therefore virulence. Modifications (as by polysaccharide N-deacetylase) and attachments differ from system to system. This Genome Property describes the variant associated with the IcaADBC operon as found in Staphylococcus epidermidis. Biosynthesis begins with UDP-N-acetylglucosamine, polymerized with beta-1,6 linkages, followed by incomplete deacetylation. |
| JCVI Role | Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides |
| Parent Property | GenProp0186: storage and structural polymer biosynthesis
|
| Gene Ontology Term | GO:0045226: extracellular polysaccharide biosynthetic process (biological_process)
|
| Step Name | Step Num | Required | Evidence (Method) | Evidence Go Terms |
|---|
| intercellular adhesin protein A | icaA | YES | 2726 (RULE_BASE)
| GO:0045226: extracellular polysaccharide biosynthetic process
|
| intercellular adhesin protein B | icaB | YES | TIGR03933 (HMM): intercellular adhesin biosynthesis polysaccharide N-deacetylase | GO:0045226: extracellular polysaccharide biosynthetic process
|
| intercellular adhesin protein C | icaC | YES | 2728 (RULE_BASE)
| GO:0045226: extracellular polysaccharide biosynthetic process
|
| intercellular adhesin protein D | icaD | YES | TIGR03932 (HMM): intracellular adhesion protein D | GO:0045226: extracellular polysaccharide biosynthetic process
|
| intercellular adhesin regulator | icaR | NO | 2727 (RULE_BASE)
| |
