Genome Property Definition Page

Namepoly(gamma-glutamic acid) biosynthesis
DescriptionPoly(gamma-glutamic acid) (PGA) is an extracellular structural polymer found Bacillus subtilis and a number of other species. Differences in stereochemistry are reported, with poly-(gamma-D-glutamate) in Bacillus anthracis but a mixture of D- and L-glutamates in Bacillus subtilis 168, Staphylococcus epidermidis ATCC 12228, and Bacillus licheniformis ATCC 14580. Because the gene symbol pgsA (nomenclature from Bacillus subtilis natto) refers to a different gene in Bacillus subtilis 168, we will use instead capB (pgsB, ywsC), capC (pgsC, ywtA), capA (pgsA, ywtB), etc. This property describes only the biosynthesis (PgsB and PgsC), and not the export or attachment machinery that differs between Gram-positive and Gram-negative systems, and between capsule-forming and secretory forms of system.
JCVI RoleOther
Parent PropertyGenProp0186: storage and structural polymer biosynthesis
Literature References
[ 1 ] Candela T, Mock M, Fouet A   CapE, a 47-amino-acid peptide, is necessary for Bacillus anthracis polyglutamate capsule synthesis.   J Bacteriol. 2005 Nov;187(22):7765-72.  PMID 16267300
[ 2 ]Candela T, Moya M, Haustant M, Fouet A  Fusobacterium nucleatum, the first Gram-negative bacterium demonstrated to produce polyglutamate.  Can J Microbiol. 2009 May;55(5):627-32.  PMID 19483793
Gene Ontology TermGO:0070501: poly-gamma-glutamate biosynthetic process (biological_process)

Step NameStep NumRequiredEvidence (Method)Evidence Go Terms
poly-gamma-glutamate synthasepgsBYESTIGR04012 (HMM): poly-gamma-glutamate synthase PgsBGO:0070501: poly-gamma-glutamate biosynthetic process
poly-gamma-glutamate biosynthesis protein PgsCpgsCYESTIGR04011 (HMM): poly-gamma-glutamate biosynthesis protein PgsCGO:0070501: poly-gamma-glutamate biosynthetic process

Parent Properties
GenProp0186storage and structural polymer biosynthesis

Sibling Properties
GenProp0055polyhydroxyalkanoic acids
GenProp0156cyanophycin-like storage polymers
GenProp0158peptidoglycan(murein) biosynthesis
GenProp0168glycogen system
GenProp0183dTDP-L-rhamnose biosynthesis from dTDP-4-dehydro-L-rhamnose
GenProp0297lipopolysaccharide biosynthesis
GenProp0652exopolysaccharide biosynthesis, exosortase A-associated
GenProp0655exopolysaccharide biosynthesis, exosortase B-associated
GenProp0658cellulose biosynthesis
GenProp0793CMP-N-acetylneuraminate biosynthesis from UDP-N-acetylglucosamine
GenProp0906poly-beta-1,6 N-acetyl-D-glucosamine system, IcaADBC type
GenProp0907poly-beta-1,6 N-acetyl-D-glucosamine system, PgaABCD type