| Accession | GenProp0822 |
| Name | poly(gamma-glutamic acid) biosynthesis |
| Type | PATHWAY |
| Description | Poly(gamma-glutamic acid) (PGA) is an extracellular structural polymer found Bacillus subtilis and a number of other species. Differences in stereochemistry are reported, with poly-(gamma-D-glutamate) in Bacillus anthracis but a mixture of D- and L-glutamates in Bacillus subtilis 168, Staphylococcus epidermidis ATCC 12228, and Bacillus licheniformis ATCC 14580. Because the gene symbol pgsA (nomenclature from Bacillus subtilis natto) refers to a different gene in Bacillus subtilis 168, we will use instead capB (pgsB, ywsC), capC (pgsC, ywtA), capA (pgsA, ywtB), etc. This property describes only the biosynthesis (PgsB and PgsC), and not the export or attachment machinery that differs between Gram-positive and Gram-negative systems, and between capsule-forming and secretory forms of system. |
| JCVI Role | Other |
| Parent Property | GenProp0186: storage and structural polymer biosynthesis
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| Literature References | [ 1 ] Candela T, Mock M, Fouet A CapE, a 47-amino-acid peptide, is necessary for Bacillus anthracis polyglutamate capsule synthesis. J Bacteriol. 2005 Nov;187(22):7765-72. PMID 16267300
[ 2 ]Candela T, Moya M, Haustant M, Fouet A Fusobacterium nucleatum, the first Gram-negative bacterium demonstrated to produce polyglutamate. Can J Microbiol. 2009 May;55(5):627-32. PMID 19483793
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| Gene Ontology Term | GO:0070501: poly-gamma-glutamate biosynthetic process (biological_process)
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