Genome Property Definition Page

Nameformate-dependent nitrite reductase, seven-gene type
DescriptionThis property describes a multiheme enzyme, cytochrome c nitrite reductase, and accessory proteins that may or may not be present. This enzyme allows formate-dependent nitrite reduction all the way to ammonia. Three of the accessory proteins are closely homologous to three genes of system I for c-type cytochrome biogenesis. This property describes the system as encoded by a seven-gene operon in Escherichia coli, six of which are modeled explicitly for this property. Several of the genes occur as paralogs of genes from the CcmABCDEFGH c-type cytochrome biogenesis system present in the same genomes. The most distinctive protein from this system is a pentaheme cytochrome c, NrfB, modeled by TIGR03146.
Parent PropertyGenProp0070: energy metabolism
GenProp0202: nitrogen metabolism

Step NameStep NumRequiredEvidence (Method)Evidence Go Terms
cytochrome c552NrfAYESPF02335 (HMM): cytochrome c552
penta-heme cytochrome cNrfBYESTIGR03146 (HMM): cytochrome c nitrite reductase, pentaheme subunit
cytochrome c nitrite reductase, NrfC subunitNrfCYESTIGR03149 (HMM): cytochrome c nitrite reductase, Fe-S protein
cytochrome c nitrite reductase, NrfD subunitNrfDYESTIGR03148 (HMM): cytochrome c nitrite reductase, NrfD subunit
accessory protein NrfENrfENOTIGR03145 (HMM): cytochrome c nitrate reductase biogenesis protein NrfE
accessory protein NrfFNrfFYESTIGR03147 (HMM): cytochrome c nitrite reductase, accessory protein NrfF

Parent Properties
GenProp0070energy metabolism
GenProp0202nitrogen metabolism

Sibling Properties
GenProp0023glyoxylate shunt
GenProp0033TCA cycle
GenProp0120pentose phosphate cycle
GenProp0131electron transport
GenProp0243ATP synthases
GenProp0459D-xylose utilization (conversion to D-xylulose-5-phosphate)
GenProp0468Entner-Doudoroff pathway
GenProp0473arsenite oxidase
GenProp0611aerobic respiration
GenProp0636respiratory nitrate reductase
GenProp0637anaerobic dimethyl sulfoxide reductase
GenProp0638trimethylamine N-oxide reductase system
GenProp0683cytochrome c nitrite reductase NrfHA
GenProp0695cytochrome b558/566
GenProp0723hydrogenase, nickel and F420-dependent
GenProp0737anaerobic glycerol-3-phosphate dehydrogenase complex
GenProp0755pyruvate conversion to propionate, anaerobic, FAD/NAD-regenerating
GenProp0756fumarate reductase complex
GenProp0764DMSO reductase family type II enzyme
GenProp08412-oxoacid:ferredoxin oxidoreductase
GenProp0856bacterio-opsin system
GenProp0914hydrogenase, [FeFe]-dependent
GenProp0915hydrogenase, mono-iron type
GenProp1089B12-dependent trimeric diol/glycerol dehydratase
GenProp1101quinoprotein cytochrome relay system
GenProp0029nitrogen fixation
GenProp0200periplasmic nitrate reductase
GenProp0666membrane-associated monooxygenase (methane/ammonia)
GenProp0814urea utilization
GenProp0899nitrile hydratase