Genome Property Definition Page

Namehydrogenase, [FeFe]-dependent
DescriptionThis system consists of two radical SAM proteins and a GTP-binding protein involved in [Fe] hydrogenase maturation.
JCVI RoleProtein modification and repair
Parent PropertyGenProp0070: energy metabolism
Literature References
[ 1 ]Posewitz MC, King PW, Smolinski SL, Zhang L, Seibert M, Ghirardi ML  Discovery of two novel radical S-adenosylmethionine proteins required for the assembly of an active [Fe] hydrogenase.  J Biol Chem. 2004 Jun 11;279(24):25711-20. Epub 2004 Apr 13.  PMID 15082711
[ 2 ]Kuchenreuther JM, Stapleton JA, Swartz JR  Tyrosine, cysteine, and S-adenosyl methionine stimulate in vitro [FeFe] hydrogenase activation.  PLoS One. 2009 Oct 26;4(10):e7565.  PMID 19855833
Gene Ontology TermGO:0006464: protein modification process (biological_process)
GO:0051188: cofactor biosynthetic process (biological_process)

Step NameStep NumRequiredEvidence (Method)Evidence Go Terms
iron hydrogenase, large subunitFe_largYESTIGR02512 (HMM): [FeFe] hydrogenase, group A
iron hydrogenase, small subunitFe_smalYESPF02256 (HMM): iron hydrogenase, small subunit
hydrogenase accessory rSAM protein HydEhydEYESTIGR03956 (HMM): [FeFe] hydrogenase H-cluster radical SAM maturase HydEGO:0051188: cofactor biosynthetic process
GO:0006464: protein modification process
hydrogenase accessory GTP-binding protein HydFhydFYESTIGR03918 (HMM): [FeFe] hydrogenase H-cluster maturation GTPase HydFGO:0051188: cofactor biosynthetic process
GO:0006464: protein modification process
hydrogenase accessory rSAM protein HydGhydGYESTIGR03955 (HMM): [FeFe] hydrogenase H-cluster radical SAM maturase HydGGO:0051188: cofactor biosynthetic process
GO:0006464: protein modification process
hydrogenase putative regulatorhyd_TFNOTIGR03959 (HMM): putative iron-only hydrogenase system regulator

Parent Properties
GenProp0070energy metabolism

Sibling Properties
GenProp0023glyoxylate shunt
GenProp0033TCA cycle
GenProp0120pentose phosphate cycle
GenProp0131electron transport
GenProp0243ATP synthases
GenProp0459D-xylose utilization (conversion to D-xylulose-5-phosphate)
GenProp0468Entner-Doudoroff pathway
GenProp0473arsenite oxidase
GenProp0611aerobic respiration
GenProp0636respiratory nitrate reductase
GenProp0637anaerobic dimethyl sulfoxide reductase
GenProp0638trimethylamine N-oxide reductase system
GenProp0682formate-dependent nitrite reductase, seven-gene type
GenProp0683cytochrome c nitrite reductase NrfHA
GenProp0695cytochrome b558/566
GenProp0723hydrogenase, nickel and F420-dependent
GenProp0737anaerobic glycerol-3-phosphate dehydrogenase complex
GenProp0755pyruvate conversion to propionate, anaerobic, FAD/NAD-regenerating
GenProp0756fumarate reductase complex
GenProp0764DMSO reductase family type II enzyme
GenProp08412-oxoacid:ferredoxin oxidoreductase
GenProp0856bacterio-opsin system
GenProp0915hydrogenase, mono-iron type
GenProp1089B12-dependent trimeric diol/glycerol dehydratase
GenProp1101quinoprotein cytochrome relay system