Genome Property Definition Page
Accession | GenProp0023 |
Name | glyoxylate shunt |
Type | PATHWAY |
Description | The glyxoylate shunt consists of two enzymes, isocitrate lyase and malate synthase. Its function is generally anaplerotic, meaning that it replenishes TCA cycle intermediates. Isocitrate (one intermediate) becomes succinate (one intermediate) plus glyoxylate. Glyoxylate plus an acetyl group from acetyl-CoA becomes malate, a second intermediate, for a gain of one. Acetyl groups, such as from fatty acid metabolism, by means of this pathway, can provide TCA cycle intermediates for use in amino acid biosynthesis and other biosynthetic pathways. |
JCVI Role | TCA cycle |
Parent Property | GenProp0070: energy metabolism |
Web References | KEGG: Glyoxylate and Dicarboxylate Metabolism IUBMB: Glyoxylate Cycle |
Gene Ontology Term | GO:0006097: glyoxylate cycle (biological_process) |
Components
Step Name | Step Num | Required | Evidence (Method) | Evidence Go Terms |
---|---|---|---|---|
isocitrate lyase | 1 | YES | TIGR01346 (HMM): isocitrate lyase 4.1.3.1 (ECNUM) | GO:0006097: glyoxylate cycle GO:0006097: glyoxylate cycle |
malate synthase | 2 | YES | TIGR01344 (HMM): malate synthase A TIGR01345 (HMM): malate synthase G 4.1.3.2 (ECNUM) | GO:0006097: glyoxylate cycle GO:0006097: glyoxylate cycle GO:0006097: glyoxylate cycle |
Parent Properties
Accession | Name |
---|---|
GenProp0070 | energy metabolism |
Sibling Properties
Accession | Name |
---|---|
GenProp0011 | methanogenesis |
GenProp0027 | photosynthesis |
GenProp0033 | TCA cycle |
GenProp0120 | pentose phosphate cycle |
GenProp0131 | electron transport |
GenProp0243 | ATP synthases |
GenProp0298 | fermentation |
GenProp0459 | D-xylose utilization (conversion to D-xylulose-5-phosphate) |
GenProp0468 | Entner-Doudoroff pathway |
GenProp0473 | arsenite oxidase |
GenProp0611 | aerobic respiration |
GenProp0636 | respiratory nitrate reductase |
GenProp0637 | anaerobic dimethyl sulfoxide reductase |
GenProp0638 | trimethylamine N-oxide reductase system |
GenProp0682 | formate-dependent nitrite reductase, seven-gene type |
GenProp0683 | cytochrome c nitrite reductase NrfHA |
GenProp0691 | glycolysis |
GenProp0695 | cytochrome b558/566 |
GenProp0723 | hydrogenase, nickel and F420-dependent |
GenProp0737 | anaerobic glycerol-3-phosphate dehydrogenase complex |
GenProp0755 | pyruvate conversion to propionate, anaerobic, FAD/NAD-regenerating |
GenProp0756 | fumarate reductase complex |
GenProp0764 | DMSO reductase family type II enzyme |
GenProp0841 | 2-oxoacid:ferredoxin oxidoreductase |
GenProp0856 | bacterio-opsin system |
GenProp0914 | hydrogenase, [FeFe]-dependent |
GenProp0915 | hydrogenase, mono-iron type |
GenProp1089 | B12-dependent trimeric diol/glycerol dehydratase |
GenProp1101 | quinoprotein cytochrome relay system |