Genome Property Definition Page

Nameglyoxylate shunt
DescriptionThe glyxoylate shunt consists of two enzymes, isocitrate lyase and malate synthase. Its function is generally anaplerotic, meaning that it replenishes TCA cycle intermediates. Isocitrate (one intermediate) becomes succinate (one intermediate) plus glyoxylate. Glyoxylate plus an acetyl group from acetyl-CoA becomes malate, a second intermediate, for a gain of one. Acetyl groups, such as from fatty acid metabolism, by means of this pathway, can provide TCA cycle intermediates for use in amino acid biosynthesis and other biosynthetic pathways.
JCVI RoleTCA cycle
Parent PropertyGenProp0070: energy metabolism
Web ReferencesKEGG: Glyoxylate and Dicarboxylate Metabolism
IUBMB: Glyoxylate Cycle
Gene Ontology TermGO:0006097: glyoxylate cycle (biological_process)

Step NameStep NumRequiredEvidence (Method)Evidence Go Terms
isocitrate lyase1YESTIGR01346 (HMM): isocitrate lyase (ECNUM)
GO:0006097: glyoxylate cycle
GO:0006097: glyoxylate cycle
malate synthase2YESTIGR01344 (HMM): malate synthase A
TIGR01345 (HMM): malate synthase G (ECNUM)
GO:0006097: glyoxylate cycle
GO:0006097: glyoxylate cycle
GO:0006097: glyoxylate cycle

Parent Properties
GenProp0070energy metabolism

Sibling Properties
GenProp0033TCA cycle
GenProp0120pentose phosphate cycle
GenProp0131electron transport
GenProp0243ATP synthases
GenProp0459D-xylose utilization (conversion to D-xylulose-5-phosphate)
GenProp0468Entner-Doudoroff pathway
GenProp0473arsenite oxidase
GenProp0611aerobic respiration
GenProp0636respiratory nitrate reductase
GenProp0637anaerobic dimethyl sulfoxide reductase
GenProp0638trimethylamine N-oxide reductase system
GenProp0682formate-dependent nitrite reductase, seven-gene type
GenProp0683cytochrome c nitrite reductase NrfHA
GenProp0695cytochrome b558/566
GenProp0723hydrogenase, nickel and F420-dependent
GenProp0737anaerobic glycerol-3-phosphate dehydrogenase complex
GenProp0755pyruvate conversion to propionate, anaerobic, FAD/NAD-regenerating
GenProp0756fumarate reductase complex
GenProp0764DMSO reductase family type II enzyme
GenProp08412-oxoacid:ferredoxin oxidoreductase
GenProp0856bacterio-opsin system
GenProp0914hydrogenase, [FeFe]-dependent
GenProp0915hydrogenase, mono-iron type
GenProp1089B12-dependent trimeric diol/glycerol dehydratase
GenProp1101quinoprotein cytochrome relay system