Genome Property Definition Page

Namereduction of oxidized methionine
DescriptionMethionine, free or in proteins, is susceptible to oxidation damage. R- and S-conformation enantiomers of methionine sulfoxide can be repaired by different reductases. MsrB (TIGR00357) was previously designated PilB because of altered cytoadherence in a mutant. MsrA and MsrB are sometimes expressed as a fusion protein.
JCVI RoleProtein modification and repair
Parent PropertyGenProp0196: sulfur metabolism
GenProp0302: protein repair
GenProp0733: amino acid salvage

Step NameStep NumRequiredEvidence (Method)Evidence Go Terms
methionine-S-sulfoxide reductaseMsrAYESTIGR00401 (HMM): peptide-methionine (S)-S-oxide reductase
methionine-R-sulfoxide reductaseMsrBYESTIGR00357 (HMM): methionine-R-sulfoxide reductase

Parent Properties
GenProp0196sulfur metabolism
GenProp0302protein repair
GenProp0733amino acid salvage

Sibling Properties
GenProp0030glutathione biosynthesis
GenProp0036biotin biosynthesis
GenProp0140iron-sulfur cluster assembly systems
GenProp0149sulfate reduction to sulfide, assimilatory
GenProp0155dissimilatory sulfate reduction
GenProp0161methionine biosynthesis from homoserine
GenProp0191sulfate/thiosulfate ABC transporter
GenProp0624sulfite reductase complex, Salmonella/Clostridium type
GenProp0654intracellular sulfur oxidation
GenProp0729methionine salvage from methylthioadenosine