Genome Property Definition Page

Namesulfate/thiosulfate ABC transporter
DescriptionThis property describes an ATP-binding cassette (ABC) transporter complex for sulfate and some related anions. Gene symbols for these proteins reflect a role of sulfate import in cysteine biosynthesis. The complex consists of four proteins, an ATP-binding protein CysA, two homologous permeases CysT and CysW, and a binding protein. In the model bacterium Escherichia coli, two binding proteins designated Sbp and CysP are present, and appear to facilitate transport of both sulfate and thiosulfate ions [1]. Unlike the case for phosphate uptake, ABC transport appears to be the only mechanism for sulfate uptake. An older report finds the sulfate transporter in E. coli also the sole transporter for selenate and selenite [2], and a review on the molybdate ABC transporter notes that, in absense of such a transporter, the sulfate transporter can take up molybdate [3].
JCVI RoleAnions
Parent PropertyGenProp0180: small molecule transport
GenProp0196: sulfur metabolism
Literature References
[ 1 ]Sirko A, Zatyka M, Sadowy E, Hulanicka D  Sulfate and thiosulfate transport in Escherichia coli K-12: evidence for a functional overlapping of sulfate- and thiosulfate-binding proteins  J Bacteriol. 1995 Jul;177(14):4134-6  PMID 7608089
[ 2 ]Lindblow-Kull C, Kull FJ, Shrift A  Single transporter for sulfate, selenate, and selenite in Escherichia coli K-12  J Bacteriol. 1985 Sep;163(3):1267-9  PMID 3897189
[ 3 ]Self WT, Grunden AM, Hasona A, Shanmugam KT  Molybdate transport  Res Microbiol. 2001 Apr-May;152(3-4):311-21  PMID 11421278
Web ReferencesTransport Classification DB: 3.A.1.6.1
Gene Ontology TermGO:0008272: sulfate transport (biological_process)
GO:0015709: thiosulfate transport (biological_process)

Step NameStep NumRequiredEvidence (Method)Evidence Go Terms
sulfate transporter ATP-binding cassette protein CysAATPcysAYESTIGR00968 (HMM): sulfate ABC transporter, ATP-binding proteinGO:0015709: thiosulfate transport
GO:0008272: sulfate transport
sulfate ABC transporter, permease permTpermTYESTIGR02139 (HMM): sulfate ABC transporter, permease protein CysTGO:0015709: thiosulfate transport
GO:0008272: sulfate transport
sulfate ABC transporter, permease protein CysWpermWYESTIGR02140 (HMM): sulfate ABC transporter, permease protein CysWGO:0015709: thiosulfate transport
GO:0008272: sulfate transport
sulfate ABC transporter, binding proteinsul_bndYESTIGR00971 (HMM): sulfate ABC transporter, sulfate-binding proteinGO:0015709: thiosulfate transport
GO:0008272: sulfate transport

Parent Properties
GenProp0180small molecule transport
GenProp0196sulfur metabolism

Sibling Properties
GenProp0119PTS transport system
GenProp0129Na+-translocating NADH-quinone reductase
GenProp0135NADH dehydrogenase I
GenProp0172Potassium-transporting ATPase KdpFABC
GenProp0176TRAP-T (tripartite ATP-independent periplasmic transporters) family transporters
GenProp0190phosphate ABC transporter (pstSCAB-phoU)
GenProp0192molybdate ABC transporter
GenProp0236phosphonates ABC transport
GenProp0252thiamine/TPP ABC transporter ThiBPQ
GenProp0279cobalt import systems
GenProp0494nickel import ABC transporter
GenProp0542Tol-Pal system
GenProp0543TonB-dependent transport
GenProp0651ectoine ABC transporter EhuABCD
GenProp0693fructose utilization as fructose-1,6-bisphosphate
GenProp0694glucose utilization as fructose-1,6-bisphosphate
GenProp07122-aminoethylphosphonate (AEP) ABC transporter, type I, PhnSTUV
GenProp07212-aminoethylphosphonate (AEP) ABC transporter, type II
GenProp0743urea ABC transporter UrtABCDE
GenProp0748choline ABC transporter, ChoXWV family
GenProp0749choline sulfate utilization
GenProp0828heme uptake system, NEAT-domain mediated
GenProp0853lantibiotic system, gallidermin/epidermin family
GenProp0873ion-motive antiporter cycles
GenProp0030glutathione biosynthesis
GenProp0036biotin biosynthesis
GenProp0140iron-sulfur cluster assembly systems
GenProp0149sulfate reduction to sulfide, assimilatory
GenProp0155dissimilatory sulfate reduction
GenProp0161methionine biosynthesis from homoserine
GenProp0182reduction of oxidized methionine
GenProp0624sulfite reductase complex, Salmonella/Clostridium type
GenProp0654intracellular sulfur oxidation
GenProp0729methionine salvage from methylthioadenosine