Genome Property Definition Page

Namesulfate reduction to sulfide, assimilatory
DescriptionThe reduction of sulfate to sulfide in sulfate assimilatory prokaryotes is initiated by the activation of sulfate in an adenylation reaction catalyzed by sulfate adenylyltransferase. The product, 5-adenylylsulfate (APS) , is either directly reduced by a thioredoxin-dependent APS reductase to sulfite, in a reaction similar to that found in sulfate dissimilators and plants, or phosphorylated to the intermediate, 3-phosphoadenylylsulfate (PAPS). The later is then reduced by a thioredoxin-dependent PAPS reductase to sulfite. The sulfite product from either branch of the assimilation pathway is enzymatically reduced by sulfite reductase to sulfide, for incorporation into an amino acid acceptor, peptide, or protein etc. [1].
JCVI RoleSulfur metabolism
Parent PropertyGenProp0196: sulfur metabolism
Literature References
[ 1 ]Bick JA, Dennis JJ, Zylstra GJ, Nowack J, Leustek T.  Identification of a new class of 5'-adenylylsulfate (APS) reductases from sulfate-assimilating bacteria.  J Bacteriol. 2000 Jan;182(1):135-42.  PMID 10613872
Web ReferencesThe Ecocyc Database: sulfate assimilation
KEGG: Sulfur metabolism
Gene Ontology TermGO:0000103: sulfate assimilation (biological_process)

Step NameStep NumRequiredEvidence (Method)Evidence Go TermsBranch
sulfate adenylyltransferase, small subunit1-CysDYESTIGR02039 (HMM): sulfate adenylyltransferase, small subunit
TIGR00339 (HMM): sulfate adenylyltransferase
sulfate adenylyltransferase, large subunit1-CysNYESTIGR02034 (HMM): sulfate adenylyltransferase, large subunit
TIGR00339 (HMM): sulfate adenylyltransferase
adenylylsulfate reductase2-CysYESTIGR02055 (HMM): adenylylsulfate reductase, thioredoxin dependent2-nonph
adenylylsulfate reductase via PAPS2-CysCYESTIGR00455 (HMM): adenylyl-sulfate kinase2-phosp
adenylylsulfate reductase via PAPS2-CysHYESTIGR02057 (HMM): phosphoadenosine phosphosulfate reductase2-phosp
adenylylsulfate reductase via PAPS2p-CysHNOTIGR00434 (HMM): phosophoadenylyl-sulfate reductase2-phosp
sulfite reductase, beta subunit3-CysIYESTIGR02041 (HMM): sulfite reductase (NADPH) hemoprotein, beta-component
TIGR02042 (HMM): sulfite reductase, ferredoxin dependent
sulfite reductase, alpha subunit3-CysJYESTIGR01931 (HMM): sulfite reductase [NADPH] flavoprotein, alpha-component
TIGR02042 (HMM): sulfite reductase, ferredoxin dependent

Parent Properties
GenProp0196sulfur metabolism

Sibling Properties
GenProp0030glutathione biosynthesis
GenProp0036biotin biosynthesis
GenProp0140iron-sulfur cluster assembly systems
GenProp0155dissimilatory sulfate reduction
GenProp0161methionine biosynthesis from homoserine
GenProp0182reduction of oxidized methionine
GenProp0191sulfate/thiosulfate ABC transporter
GenProp0624sulfite reductase complex, Salmonella/Clostridium type
GenProp0654intracellular sulfur oxidation
GenProp0729methionine salvage from methylthioadenosine