Genome Property Definition Page
Accession | GenProp0876 | |
Name | decarboxylation/antiport proton-motive cycle: glutamate-GABA | |
Type | SYSTEM | |
Description | The decarboxylation of glutamate to 4-aminobutanoate, also known as gamma-aminobutyrate or GABA, coupled with glutamate-GABA antiport, provides a robust mechanism of glutamate-based acid resistance for Escherichia coli and other organisms that need to survive transient exposures to highly acidic pH. Import of the negatively charged glutamate, decarboxylation with the consumption of a proton, and export of the neutral molecule GABA serves to reduce cytosolic acidity. Similar cycles are driven by the decarboxylation of other amino acids. | |
JCVI Role | Adaptations to atypical conditions | |
Parent Property | GenProp0873: ion-motive antiporter cycles | |
Literature References |
| |
Gene Ontology Term | GO:0010447: response to acidity (biological_process) |
Components
Step Name | Step Num | Required | Evidence (Method) | Evidence Go Terms |
---|---|---|---|---|
glutamate decarboxylase | gadAB | YES | TIGR01788 (HMM): glutamate decarboxylase | GO:0010447: response to acidity |
glutamate/GABA antiporter | gadC | YES | TIGR00910 (HMM): glutamate:gamma-aminobutyrate antiporter | GO:0010447: response to acidity |
transcriptional activator GadE | gadE | NO | 2656 (RULE_BASE) | GO:0010447: response to acidity |
transcriptional activator GadW | gadW | NO | 2655 (RULE_BASE) | GO:0010447: response to acidity |
transcriptional regulator GadX | gadX | NO | 2657 (RULE_BASE) | GO:0010447: response to acidity |
Parent Properties
Accession | Name |
---|---|
GenProp0873 | ion-motive antiporter cycles |
Sibling Properties
Accession | Name |
---|---|
GenProp0639 | arginine degradation via citrulline, ATP-generating |
GenProp0867 | decarboxylation/antiport proton-motive cycle: aspartate-alanine |
GenProp0869 | decarboxylation/antiport proton-motive cycle: arginine-agmatine |
GenProp0870 | decarboxylation/antiport proton-motive cycle: lysine-cadaverine |
GenProp0871 | decarboxylation/antiport proton-motive cycle: ornithine-putrescine |
GenProp0872 | decarboxylation/antiport proton-motive cycle: histidine-histamine |
GenProp0875 | decarboxylation/antiport proton-motive cycle: tyrosine-tyramine |
GenProp1034 | decarboxylation/antiport proton-motive cycle: oxalate-formate |