Genome Property Definition Page

Namedecarboxylation/antiport proton-motive cycle: glutamate-GABA
DescriptionThe decarboxylation of glutamate to 4-aminobutanoate, also known as gamma-aminobutyrate or GABA, coupled with glutamate-GABA antiport, provides a robust mechanism of glutamate-based acid resistance for Escherichia coli and other organisms that need to survive transient exposures to highly acidic pH. Import of the negatively charged glutamate, decarboxylation with the consumption of a proton, and export of the neutral molecule GABA serves to reduce cytosolic acidity. Similar cycles are driven by the decarboxylation of other amino acids.
JCVI RoleAdaptations to atypical conditions
Parent PropertyGenProp0873: ion-motive antiporter cycles
Literature References
[ 1 ] Kailasan Vanaja S, Bergholz TM, Whittam TS   Characterization of the Escherichia coli O157:H7 Sakai GadE regulon.   J Bacteriol. 2009 Mar;191(6):1868-77.  PMID 19114477
Gene Ontology TermGO:0010447: response to acidity (biological_process)

Step NameStep NumRequiredEvidence (Method)Evidence Go Terms
glutamate decarboxylasegadABYESTIGR01788 (HMM): glutamate decarboxylaseGO:0010447: response to acidity
glutamate/GABA antiportergadCYESTIGR00910 (HMM): glutamate:gamma-aminobutyrate antiporterGO:0010447: response to acidity
transcriptional activator GadEgadENO2656 (RULE_BASE)
GO:0010447: response to acidity
transcriptional activator GadWgadWNO2655 (RULE_BASE)
GO:0010447: response to acidity
transcriptional regulator GadXgadXNO2657 (RULE_BASE)
GO:0010447: response to acidity

Parent Properties
GenProp0873ion-motive antiporter cycles

Sibling Properties
GenProp0639arginine degradation via citrulline, ATP-generating
GenProp0867decarboxylation/antiport proton-motive cycle: aspartate-alanine
GenProp0869decarboxylation/antiport proton-motive cycle: arginine-agmatine
GenProp0870decarboxylation/antiport proton-motive cycle: lysine-cadaverine
GenProp0871decarboxylation/antiport proton-motive cycle: ornithine-putrescine
GenProp0872decarboxylation/antiport proton-motive cycle: histidine-histamine
GenProp0875decarboxylation/antiport proton-motive cycle: tyrosine-tyramine
GenProp1034decarboxylation/antiport proton-motive cycle: oxalate-formate