Accession | GenProp1034 |
Name | decarboxylation/antiport proton-motive cycle: oxalate-formate |
Type | SYSTEM |
Description | This Genome Property represents a proton-motive cycle. The cycle of decarboxylating oxalate, a dicarboxylic acid, to formate plus CO2, then exchanging the cytosolic formate for an extracellular oxalate, has the net effect of consuming one proton. This property has been studied extensively in Oxalobacter formigenes, which appears in the human microbiome and affects oxalate homeostasis. |
Parent Property | GenProp0873: ion-motive antiporter cycles
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Literature References | [ 1 ]Maloney PC, Yan RT, Abe K Bacterial anion exchange: reductionist and integrative approaches to membrane biology. J Exp Biol. 1994 Nov;196:471-82. PMID 7823041 [ 2 ]Anantharam V, Allison MJ, Maloney PC Oxalate:formate exchange. The basis for energy coupling in Oxalobacter. J Biol Chem. 1989 May 5;264(13):7244-50. PMID 2708365 [ 3 ]Hatch M, Freel RW The roles and mechanisms of intestinal oxalate transport in oxalate homeostasis. Semin Nephrol. 2008 Mar;28(2):143-51. PMID 18359395 |
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