Genome Property Definition Page

Namedecarboxylation/antiport proton-motive cycle: oxalate-formate
DescriptionThis Genome Property represents a proton-motive cycle. The cycle of decarboxylating oxalate, a dicarboxylic acid, to formate plus CO2, then exchanging the cytosolic formate for an extracellular oxalate, has the net effect of consuming one proton. This property has been studied extensively in Oxalobacter formigenes, which appears in the human microbiome and affects oxalate homeostasis.
Parent PropertyGenProp0873: ion-motive antiporter cycles
Literature References
[ 1 ]Maloney PC, Yan RT, Abe K  Bacterial anion exchange: reductionist and integrative approaches to membrane biology.  J Exp Biol. 1994 Nov;196:471-82.  PMID 7823041
[ 2 ]Anantharam V, Allison MJ, Maloney PC  Oxalate:formate exchange. The basis for energy coupling in Oxalobacter.  J Biol Chem. 1989 May 5;264(13):7244-50.  PMID 2708365
[ 3 ]Hatch M, Freel RW  The roles and mechanisms of intestinal oxalate transport in oxalate homeostasis.  Semin Nephrol. 2008 Mar;28(2):143-51.  PMID 18359395

Step NameStep NumRequiredEvidence (Method)Evidence Go Terms
decarboxylationdecarbYESGenProp0718 (GENPROP): oxalate degradation
oxalate/formate antiporteroxlTYESTIGR04259 (HMM): oxalate/formate antiporter

Parent Properties
GenProp0873ion-motive antiporter cycles

Sibling Properties
GenProp0639arginine degradation via citrulline, ATP-generating
GenProp0867decarboxylation/antiport proton-motive cycle: aspartate-alanine
GenProp0869decarboxylation/antiport proton-motive cycle: arginine-agmatine
GenProp0870decarboxylation/antiport proton-motive cycle: lysine-cadaverine
GenProp0871decarboxylation/antiport proton-motive cycle: ornithine-putrescine
GenProp0872decarboxylation/antiport proton-motive cycle: histidine-histamine
GenProp0875decarboxylation/antiport proton-motive cycle: tyrosine-tyramine
GenProp0876decarboxylation/antiport proton-motive cycle: glutamate-GABA