Genome Property Definition Page
| Accession | GenProp0872 | |
| Name | decarboxylation/antiport proton-motive cycle: histidine-histamine | |
| Type | SYSTEM | |
| Description | The decarboxylation of histidine to histamine consumes a proton. Exchange of histamine for histadine by an antiporter completes a cycle that effectively removes a cytosolic proton. Decarboxylation/antiporter systems for this and other (e.g. aspartate-alanine) substrate pairs can provide protection against acidic pH. | |
| JCVI Role | Adaptations to atypical conditions | |
| Parent Property | GenProp0873: ion-motive antiporter cycles GenProp0874: response to acid (low pH) environment | |
| Literature References |
| |
| Gene Ontology Term | GO:0010248: establishment or maintenance of transmembrane electrochemical gradient (biological_process) |
Components
| Step Name | Step Num | Required | Evidence (Method) | Evidence Go Terms |
|---|---|---|---|---|
| histidine decarboxylase | HdcA | YES | TIGR00541 (HMM): histidine decarboxylase, pyruvoyl type | GO:0010248: establishment or maintenance of transmembrane electrochemical gradient |
| histidine-histamine antiporter | HdcC | YES | 2639 (RULE_BASE) 2642 (RULE_BASE) TIGR04298 (HMM): histidine-histamine antiporter | GO:0010248: establishment or maintenance of transmembrane electrochemical gradient GO:0010248: establishment or maintenance of transmembrane electrochemical gradient GO:0010248: establishment or maintenance of transmembrane electrochemical gradient |
Parent Properties
| Accession | Name |
|---|---|
| GenProp0873 | ion-motive antiporter cycles |
| GenProp0874 | response to acid (low pH) environment |
Sibling Properties
| Accession | Name |
|---|---|
| GenProp0639 | arginine degradation via citrulline, ATP-generating |
| GenProp0867 | decarboxylation/antiport proton-motive cycle: aspartate-alanine |
| GenProp0869 | decarboxylation/antiport proton-motive cycle: arginine-agmatine |
| GenProp0870 | decarboxylation/antiport proton-motive cycle: lysine-cadaverine |
| GenProp0871 | decarboxylation/antiport proton-motive cycle: ornithine-putrescine |
| GenProp0875 | decarboxylation/antiport proton-motive cycle: tyrosine-tyramine |
| GenProp0876 | decarboxylation/antiport proton-motive cycle: glutamate-GABA |
| GenProp1034 | decarboxylation/antiport proton-motive cycle: oxalate-formate |