Genome Property Definition Page

Namedecarboxylation/antiport proton-motive cycle: lysine-cadaverine
DescriptionThe decarboxylation of lysine to cadaverine consumes a proton. Exchange of lysine for cadaverine by an antiporter completes a cycle that effectively removes a cytosolic proton. Decarboxylation/antiporter systems for this and other (e.g. aspartate-alanine) substrate pairs can provide protection against acidic pH.
JCVI RoleAdaptations to atypical conditions
Parent PropertyGenProp0873: ion-motive antiporter cycles
GenProp0874: response to acid (low pH) environment
Literature References
[ 1 ] Soksawatmaekhin W, Uemura T, Fukiwake N, Kashiwagi K, Igarashi K   Identification of the cadaverine recognition site on the cadaverine-lysine antiporter CadB.   J Biol Chem. 2006 Sep 29;281(39):29213-20.  PMID 16877381
Gene Ontology TermGO:0010248: establishment or maintenance of transmembrane electrochemical gradient (biological_process)

Step NameStep NumRequiredEvidence (Method)Evidence Go Terms
lysine decarboxylaseCadAYES2645 (RULE_BASE)
GO:0010248: establishment or maintenance of transmembrane electrochemical gradient
cadaverine-lysine antiporterCadBYES2644 (RULE_BASE)
GO:0010248: establishment or maintenance of transmembrane electrochemical gradient

Parent Properties
GenProp0873ion-motive antiporter cycles
GenProp0874response to acid (low pH) environment

Sibling Properties
GenProp0639arginine degradation via citrulline, ATP-generating
GenProp0867decarboxylation/antiport proton-motive cycle: aspartate-alanine
GenProp0869decarboxylation/antiport proton-motive cycle: arginine-agmatine
GenProp0871decarboxylation/antiport proton-motive cycle: ornithine-putrescine
GenProp0872decarboxylation/antiport proton-motive cycle: histidine-histamine
GenProp0875decarboxylation/antiport proton-motive cycle: tyrosine-tyramine
GenProp0876decarboxylation/antiport proton-motive cycle: glutamate-GABA
GenProp1034decarboxylation/antiport proton-motive cycle: oxalate-formate