Genome Property Definition Page

Namedecarboxylation/antiport proton-motive cycle: tyrosine-tyramine
DescriptionThe decarboxylation of tyrosine to tyramine consumes a proton. Exchange of tyrosine for tyramine by an antiporter completes a cycle that effectively removes a cytosolic proton. Decarboxylation/antiporter systems for this and other (e.g. aspartate-alanine) substrate pairs can provide protection against acidic pH.
Parent PropertyGenProp0873: ion-motive antiporter cycles
GenProp0874: response to acid (low pH) environment
Literature References
[ 1 ] Connil N, Le Breton Y, Dousset X, Auffray Y, Rince A, Prevost H   Identification of the Enterococcus faecalis tyrosine decarboxylase operon involved in tyramine production.   Appl Environ Microbiol. 2002 Jul;68(7):3537-44.  PMID 12089039

Step NameStep NumRequiredEvidence (Method)Evidence Go Terms
tyrosine-tyramine antiporterTyrAntiYES
tyrosine decarboxylaseTyr_CO2YESTIGR03811 (HMM): tyrosine decarboxylase

Parent Properties
GenProp0873ion-motive antiporter cycles
GenProp0874response to acid (low pH) environment

Sibling Properties
GenProp0639arginine degradation via citrulline, ATP-generating
GenProp0867decarboxylation/antiport proton-motive cycle: aspartate-alanine
GenProp0869decarboxylation/antiport proton-motive cycle: arginine-agmatine
GenProp0870decarboxylation/antiport proton-motive cycle: lysine-cadaverine
GenProp0871decarboxylation/antiport proton-motive cycle: ornithine-putrescine
GenProp0872decarboxylation/antiport proton-motive cycle: histidine-histamine
GenProp0876decarboxylation/antiport proton-motive cycle: glutamate-GABA
GenProp1034decarboxylation/antiport proton-motive cycle: oxalate-formate