| Accession | GenProp0678 |
| Name | c-type cytochrome biogenesis, system I |
| Type | SYSTEM |
| Description | Assembling c-type cytochromes outside the bacterial inner membrane requires apocytochome export, heme export, heme ligation, and chaperones for both heme and apocytochromes, Of three different c-type cytochrome biogenesis systems, this is system I. It features the operon ccmABCDEFGHI in Escherichia coli and the equivalent genes in many other bacterial species. |
| JCVI Role | Electron transport |
| Parent Property | GenProp0167: cellular growth, organization and division
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| Literature References | [ 1 ]Ahuja U, Thony-Meyer L CcmD is involved in complex formation between CcmC and the heme chaperone CcmE during cytochrome c maturation. J Biol Chem. 2005 Jan 7;280(1):236-43. Epub 2004 Oct 28. PMID 15513913
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| Step Name | Step Num | Required | Evidence (Method) | Evidence Go Terms |
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| heme ABC exporter, ATP-binding protein CcmA | CcmA | YES | TIGR01189 (HMM): heme ABC exporter, ATP-binding protein CcmA | |
| heme exporter protein CcmB | CcmB | YES | TIGR01190 (HMM): heme exporter protein CcmB | |
| heme exporter protein CcmC | CcmC | YES | TIGR01191 (HMM): heme exporter protein CcmC | |
| heme exporter protein CcmD | CcmD | YES | PF04995 (HMM): heme exporter protein D
TIGR04391 (HMM-CLUST): CcmD family protein | |
| cytochrome c-type biogenesis protein CcmE | CcmE | YES | PF03100 (HMM): cytochrome c-type biogenesis protein CcmE | |
| cytochrome c-type biogenesis protein CcmF | CcmF | YES | TIGR00353 (HMM): cytochrome c-type biogenesis protein CcmF | |
| CcmG protein | CcmG | YES | TIGR00385 (HMM): periplasmic protein thiol:disulfide oxidoreductases, DsbE subfamily | |
| cytochrome C biogenesis protein CcmH/CycL/NrfF/Ccl2 | CcmH | YES | PF03918 (HMM): cytochrome c biogenesis protein | |
| cytochrome c-type biogenesis protein CcmI | CcmI | NO | TIGR03142 (HMM): cytochrome c-type biogenesis protein CcmI | |
