Genome Property Definition Page

Accession

GenProp0676

Name

alkylhydroperoxide reductase AhpCF (peroxiredoxin)

Type

SYSTEM

Description

This two-gene peroxiredoxin consists of ahpC and ahpF, ususally as tandem genes in an apparent operon. Peroxiredoxin detoxifies alkyl hydroperoxides by catalyzing the oxidation of an active site cysteine (on AhpC) to a sulfenic acid. This subsequently becomes a disulfide which is then resolved by reduction. AhpF contains an FAD-binding domain along with a NAD(P)H binding domain (PF07992).

JCVI Role

Detoxification

Parent Property

GenProp0213: Resistance to Reactive Oxygen Species (ROS)
GenProp0303: detoxification

Literature References

[ 1 ]Rocha ER, Smith CJ Role of the alkyl hydroperoxide reductase (ahpCF) gene in oxidative stress defense of the obligate Anaerobe bacteroides fragilis. J Bacteriol. 1999 Sep;181(18):5701-10. PMID 10482511

Gene Ontology Term

GO:0006800: oxygen and reactive oxygen species metabolic process (biological_process)

Components

Step Name	Step Num	Required	Evidence (Method)	Evidence Go Terms
subunit C	ahpC	YES	TIGR03137 (HMM): peroxiredoxin	GO:0006800: oxygen and reactive oxygen species metabolic process
subunit F	ahpF	YES	TIGR03140 (HMM): alkyl hydroperoxide reductase subunit F TIGR03143 (HMM): putative alkyl hydroperoxide reductase F subunit	GO:0006800: oxygen and reactive oxygen species metabolic process GO:0006800: oxygen and reactive oxygen species metabolic process

Parent Properties

Accession	Name
GenProp0213	Resistance to Reactive Oxygen Species (ROS)
GenProp0303	detoxification

Sibling Properties

Accession	Name
GenProp0151	resistance to mercury
GenProp0213	Resistance to Reactive Oxygen Species (ROS)
GenProp0474	arsenical resistance system
GenProp0488	superoxide dismutase, nickel-type
GenProp0562	formaldehyde detoxification, glutathione-dependent
GenProp0673	ribulose monophosphate pathway
GenProp0744	glyoxalase pathway, glutathione dependent