Genome Property Definition Page
| Accession | GenProp0474 |
| Name | arsenical resistance system |
| Type | SYSTEM |
| Description | A characteristic four-gene system for arsenic (and antimony) resistance is found in many prokaryotic genomes. The system includes a pump for extrusion of arsenite, an arsenate reductase that converts arsenate to arsenite for transport, a protein ArsH of unknown function that is sometimes not required, and a regulatory protein. Several distinct families are known for the arsenate reductase, ArsC, which may be dependent on glutaredoxin or thioredoxin in different instances. |
| JCVI Role | Detoxification |
| Parent Property | GenProp0303: detoxification |
Components
| Step Name | Step Num | Required | Evidence (Method) | Evidence Go Terms |
|---|---|---|---|---|
| arsenical resistance protein ArsH | arsH | YES | TIGR02690 (HMM): arsenical resistance protein ArsH | |
| arsenical resistance regulator ArsR | arsR | YES | PF01022 (HMM-CLUST): transcriptional regulator, ArsR family | |
| arsenite efflux transporter ArsB | pump | YES | TIGR00832 (HMM): arsenical-resistance protein TIGR00935 (HMM): arsenite/antimonite efflux pump membrane protein | |
| arsenate reductase | reduct | YES | TIGR02691 (HMM): arsenate reductase (thioredoxin) TIGR02689 (HMM): arsenate reductase, glutathione/glutaredoxin type TIGR00014 (HMM-CLUST): arsenate reductase (glutaredoxin) PF01451 (HMM-CLUST): low molecular weight phosphotyrosine protein phosphatase |
Parent Properties
| Accession | Name |
|---|---|
| GenProp0303 | detoxification |
Sibling Properties
| Accession | Name |
|---|---|
| GenProp0151 | resistance to mercury |
| GenProp0213 | Resistance to Reactive Oxygen Species (ROS) |
| GenProp0488 | superoxide dismutase, nickel-type |
| GenProp0562 | formaldehyde detoxification, glutathione-dependent |
| GenProp0673 | ribulose monophosphate pathway |
| GenProp0676 | alkylhydroperoxide reductase AhpCF (peroxiredoxin) |
| GenProp0744 | glyoxalase pathway, glutathione dependent |