Genome Property Definition Page

Nameribulose monophosphate pathway
DescriptionThe ribulose monophosphate pathway consists of two enzyme, 3-hexulose-6-phosphate synthase (HPS) and 6-phospho-3-hexuloisomerase (PHI). In one direction, this pathway removes the toxic metabolite formaldehyde by assimilation. In the other direction, in certain species lacking the complete pentose phosphate pathway, this pathway produces consumes fructose 6-phosphate and releases formaldehyde in order to produce ribulose-5-phosphate, essential for nucleotide biosynthesis. The two enzymes may occur as a fusion protein, as in Thermococcus kodakaraensis.
Parent PropertyGenProp0185: nucleotide biosynthesis
GenProp0303: detoxification
Literature References
[ 1 ]Orita I, Sato T, Yurimoto H, Kato N, Atomi H, Imanaka T, Sakai Y  The ribulose monophosphate pathway substitutes for the missing pentose phosphate pathway in the archaeon Thermococcus kodakaraensis.  J Bacteriol. 2006 Jul;188(13):4698-704.  PMID 16788179
[ 2 ]Grochowski LL, Xu H, White RH  Ribose-5-phosphate biosynthesis in Methanocaldococcus jannaschii occurs in the absence of a pentose-phosphate pathway.  J Bacteriol. 2005 Nov;187(21):7382-9.  PMID 16237021
[ 3 ]Yurimoto H, Hirai R, Matsuno N, Yasueda H, Kato N, Sakai Y  HxlR, a member of the DUF24 protein family, is a DNA-binding protein that acts as a positive regulator of the formaldehyde-inducible hxlAB operon in Bacillus subtilis.  Mol Microbiol. 2005 Jul;57(2):511-9.  PMID 15978081

Step NameStep NumRequiredEvidence (Method)Evidence Go Terms
3-hexulose-6-phosphate synthaseHPSYESTIGR03128 (HMM): 3-hexulose-6-phosphate synthase
6-phospho-3-hexuloisomerasePHIYESTIGR03127 (HMM): 6-phospho 3-hexuloisomerase

Parent Properties
GenProp0185nucleotide biosynthesis

Sibling Properties
GenProp0110purine (inosine-5'-phosphate) biosynthesis from ribose-5-phosphate
GenProp0187pyrimidine (uridine-5'-phosphate) de novo biosynthesis
GenProp0696xanthine utilization as a source of guanine-monophosphate (GMP)
GenProp0697guanine monophosphate (GMP) biosynthesis from inosine monophosphate (IMP)
GenProp0747adenosine monophosphate (AMP) biosynthesis from inosine monophosphate (IMP)
GenProp0151resistance to mercury
GenProp0213Resistance to Reactive Oxygen Species (ROS)
GenProp0474arsenical resistance system
GenProp0488superoxide dismutase, nickel-type
GenProp0562formaldehyde detoxification, glutathione-dependent
GenProp0676alkylhydroperoxide reductase AhpCF (peroxiredoxin)
GenProp0744glyoxalase pathway, glutathione dependent