Genome Property Definition Page

Namechaperone system: DnaK-DnaJ-GrpE
DescriptionDnaK, DnaJ, and GrpE form a chaperone system. DnaK has ATPase activity. DnaJ and GrpE are co-chaperones for DnaK, that is, stimulate this activity. This system is also called the hsp70 heat-shock system. Excluded from this system are the heat shock cognate (Hsc) homologs, which are associated specifically with iron-sulfur cluster biosynthesis (see GenProp0138, the iron-sulfur cluster assembly iscSUA-hscBA-fdx system). The heat shock repressor HrcA is found in about half of bacterial genomes with the DnaK-DnaJ-GrpE heat shock system, usually encoded upstream in a heat shock operon; it is included here as an optional component.
JCVI RoleProtein folding and stabilization
Parent PropertyGenProp0248: protein folding
Literature References
[ 1 ]Brehmer D, Gassler C, Rist W, Mayer MP, Bukau B  Influence of GrpE on DnaK-substrate interactions.  J Biol Chem 2004 Jul 2;279(27):27957-64. Epub 2004 Apr 21.  PMID 15102842
Web ReferencesThe Ecocyc Database: Protein: DnaJ/DnaK/GrpE
Gene Ontology TermGO:0006457: protein folding (biological_process)
GO:0016481: negative regulation of transcription (biological_process)

Step NameStep NumRequiredEvidence (Method)Evidence Go Terms
co-chaperone DnaJDnaJYESTIGR02349 (HMM): chaperone protein DnaJGO:0006457: protein folding
chaperone DnaKDnaKYESTIGR02350 (HMM): chaperone protein DnaKGO:0006457: protein folding
co-chaperone GrpEGrpEYESPF01025 (HMM): co-chaperone GrpEGO:0006457: protein folding
heat shock gene repressor HrcAHrcANOTIGR00331 (HMM): heat-inducible transcription repressor HrcAGO:0016481: negative regulation of transcription

Parent Properties
GenProp0248protein folding

Sibling Properties
GenProp0245chaperone system: GroEL/GroES
GenProp0246chaperone system: thermosome/prefoldin
GenProp0725outer membrane protein assembly complex
GenProp0928OMP chaperone system: SurA-Skp-DegP