Genome Property Definition Page

Namechaperone system: thermosome/prefoldin
DescriptionThe archaeal thermosome system is a group II chaperonin, closely related to the CCT complex of eukaryotes. Thermosome subunits show clear remote sequence similarity to GroEL of the bacterial group I chaperonin system. Prefoldin, with alpha and beta subunits, works with the chaperonin. The number of distinct but homologous genes for subunits of the thermosome ranges from one to five in the archaea, and this property is based simply on finding at least one, plus the two subunits of the archaeal form of prefoldin.
JCVI RoleProtein folding and stabilization
Parent PropertyGenProp0248: protein folding
Literature References
[ 1 ]Gutsche I, Essen LO, Baumeister W.  Group II chaperonins: new TRiC(k)s and turns of a protein folding machine.  J Mol Biol. 1999 Oct 22;293(2):295-312. Review.  PMID 10550210
[ 2 ]Klumpp M, Baumeister W.  The thermosome: archetype of group II chaperonins.  FEBS Lett. 1998 Jun 23;430(1-2):73-7. Review.  PMID 9678597
Gene Ontology TermGO:0006457: protein folding (biological_process)

Step NameStep NumRequiredEvidence (Method)Evidence Go Terms
prefoldin, alpha subunitprefldAYESTIGR00293 (HMM): prefoldin, alpha subunitGO:0006457: protein folding
prefoldin, beta subunitprefldBYESTIGR02338 (HMM): prefoldin, beta subunitGO:0006457: protein folding
thermosome subunit(s)thrmsomYESTIGR02339 (HMM): thermosome, various subunits, archaealGO:0006457: protein folding

Parent Properties
GenProp0248protein folding

Sibling Properties
GenProp0244chaperone system: DnaK-DnaJ-GrpE
GenProp0245chaperone system: GroEL/GroES
GenProp0725outer membrane protein assembly complex
GenProp0928OMP chaperone system: SurA-Skp-DegP