Accession | GenProp0246 |
Name | chaperone system: thermosome/prefoldin |
Type | SYSTEM |
Description | The archaeal thermosome system is a group II chaperonin, closely related to the CCT complex of eukaryotes. Thermosome subunits show clear remote sequence similarity to GroEL of the bacterial group I chaperonin system. Prefoldin, with alpha and beta subunits, works with the chaperonin. The number of distinct but homologous genes for subunits of the thermosome ranges from one to five in the archaea, and this property is based simply on finding at least one, plus the two subunits of the archaeal form of prefoldin. |
JCVI Role | Protein folding and stabilization |
Parent Property | GenProp0248: protein folding
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Literature References | [ 1 ]Gutsche I, Essen LO, Baumeister W. Group II chaperonins: new TRiC(k)s and turns of a protein folding machine. J Mol Biol. 1999 Oct 22;293(2):295-312. Review. PMID 10550210 [ 2 ]Klumpp M, Baumeister W. The thermosome: archetype of group II chaperonins. FEBS Lett. 1998 Jun 23;430(1-2):73-7. Review. PMID 9678597 |
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Gene Ontology Term | GO:0006457: protein folding (biological_process)
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