Genome Property Definition Page

Accession

GenProp0950

Name

4,6-dideoxy-4-oxo-dTDP-D-glucose biosynthesis from glucose-1-phosphate

Type

PATHWAY

Description

4,6-dideoxy-4-oxo-dTDP-D-glucose is an intermediate in the biosynthesis of L-rhamnose and D-fucosamine derivatives.

Literature References

[ 1 ]Dong C, Beis K, Giraud MF, Blankenfeldt W, Allard S, Major LL, Kerr ID, Whitfield C, Naismith JH. A structural perspective on the enzymes that convert dTDP-d-glucose into dTDP-l-rhamnose. Biochem Soc Trans. 2003 Jun;31(Pt 3):532-6. PMID 12773151

Web References

IUBMB: 6-Deoxyhexose Biosynthesis

Components

Step Name	Step Num	Required	Evidence (Method)	Evidence Go Terms
glucose-1-phosphate thymidylyltransferase	rfbA	YES	TIGR01207 (HMM): glucose-1-phosphate thymidylyltransferase TIGR01208 (HMM): glucose-1-phosphate thymidylyltransferase
dTDP-glucose 4,6-dehydratase	rfbB	YES	TIGR01181 (HMM): dTDP-glucose 4,6-dehydratase

Child Properties

Accession	Name
GenProp0183	dTDP-L-rhamnose biosynthesis from dTDP-4-dehydro-L-rhamnose
GenProp0951	dTDP-3-aminofucose biosynthesis from 4,6-dideoxy-4-oxo-dTDP-D-glucose
GenProp0972	dTDP-4-acetamido-4,6-dideoxy-D-galactose (dTDP-Fuc4NAc) biosynthesis
GenProp1015	dTDP-3-amino-3,6-dideoxy-D-glucose (Qui3N) biosynthesis from 4,6-dideoxy-4-oxo-dTDP-D-glucose