Genome Property Definition Page
| Accession | GenProp1015 |
| Name | dTDP-3-amino-3,6-dideoxy-D-glucose (Qui3N) biosynthesis from 4,6-dideoxy-4-oxo-dTDP-D-glucose |
| Type | METAPATH |
| Description | dTDP-3-amino-3,6-dideoxy-D-glucose is a precursor of (at least) two exopolysaccharide components, 3-acetamido-3,6-dideoxy-D-glucose (D-Qui3NAc), found in the E. coli O5, O65 and O71 antigens (as well as others), and a variant containing an N-acetyl-L-seryl group in place of the acetyl observed in the O114 antigen. It is synthesized in the O5 antigen biosynthesis cluster from the common intermediate 4,6-dideoxy-4-oxo-dTDP-D-glucose by the RfbA and RfbB genes. The pathway to Qui3NAc is parallel to that generating Fuc3NAc from the same intermediate, utilizing an isomerase (FdtA ~ QdtA), an aminotransferase (FdtB ~ QdtB) and an acetyltransferase (FdtC ~ QdtC). The two sugars differ only in the chirality at C4. |
| Parent Property | GenProp0950: 4,6-dideoxy-4-oxo-dTDP-D-glucose biosynthesis from glucose-1-phosphate |
Components
| Step Name | Step Num | Required | Evidence (Method) | Evidence Go Terms |
|---|---|---|---|---|
| dTDP-6-deoxy-3,4-keto-hexulose isomerase QdtA | QdtA | YES | 2862 (RULE_BASE) | |
| dTDP-6-deoxy-D-glucohex-4-ulose 3-aminotransferase | QdtB | YES | 2863 (RULE_BASE) | |
| source of 4,6-dideoxy-4-oxo-dTDP-D-glucose | ddodtDg | YES | GenProp0950 (GENPROP): 4,6-dideoxy-4-oxo-dTDP-D-glucose biosynthesis from glucose-1-phosphate |
Parent Properties
| Accession | Name |
|---|---|
| GenProp0950 | 4,6-dideoxy-4-oxo-dTDP-D-glucose biosynthesis from glucose-1-phosphate |
Sibling Properties
| Accession | Name |
|---|---|
| GenProp0183 | dTDP-L-rhamnose biosynthesis from dTDP-4-dehydro-L-rhamnose |
| GenProp0951 | dTDP-3-aminofucose biosynthesis from 4,6-dideoxy-4-oxo-dTDP-D-glucose |
| GenProp0972 | dTDP-4-acetamido-4,6-dideoxy-D-galactose (dTDP-Fuc4NAc) biosynthesis |