Genome Property Definition Page

NamedTDP-3-amino-3,6-dideoxy-D-glucose (Qui3N) biosynthesis from 4,6-dideoxy-4-oxo-dTDP-D-glucose
DescriptiondTDP-3-amino-3,6-dideoxy-D-glucose is a precursor of (at least) two exopolysaccharide components, 3-acetamido-3,6-dideoxy-D-glucose (D-Qui3NAc), found in the E. coli O5, O65 and O71 antigens (as well as others), and a variant containing an N-acetyl-L-seryl group in place of the acetyl observed in the O114 antigen. It is synthesized in the O5 antigen biosynthesis cluster from the common intermediate 4,6-dideoxy-4-oxo-dTDP-D-glucose by the RfbA and RfbB genes. The pathway to Qui3NAc is parallel to that generating Fuc3NAc from the same intermediate, utilizing an isomerase (FdtA ~ QdtA), an aminotransferase (FdtB ~ QdtB) and an acetyltransferase (FdtC ~ QdtC). The two sugars differ only in the chirality at C4.
Parent PropertyGenProp0950: 4,6-dideoxy-4-oxo-dTDP-D-glucose biosynthesis from glucose-1-phosphate

Step NameStep NumRequiredEvidence (Method)Evidence Go Terms
dTDP-6-deoxy-3,4-keto-hexulose isomerase QdtAQdtAYES2862 (RULE_BASE)
dTDP-6-deoxy-D-glucohex-4-ulose 3-aminotransferaseQdtBYES2863 (RULE_BASE)
source of 4,6-dideoxy-4-oxo-dTDP-D-glucoseddodtDgYESGenProp0950 (GENPROP): 4,6-dideoxy-4-oxo-dTDP-D-glucose biosynthesis from glucose-1-phosphate

Parent Properties
GenProp09504,6-dideoxy-4-oxo-dTDP-D-glucose biosynthesis from glucose-1-phosphate

Sibling Properties
GenProp0183dTDP-L-rhamnose biosynthesis from dTDP-4-dehydro-L-rhamnose
GenProp0951dTDP-3-aminofucose biosynthesis from 4,6-dideoxy-4-oxo-dTDP-D-glucose
GenProp0972dTDP-4-acetamido-4,6-dideoxy-D-galactose (dTDP-Fuc4NAc) biosynthesis