Genome Property Definition Page
Accession | GenProp0253 |
Name | thiamine: hydroxymethylpyrimidine pyrophosphate from aminoimidazole ribotide |
Type | PATHWAY |
Description | Hydroxymethylpyrimidine pyrophosphate (HMP-PP) and hydroxyethylthiazole phosphate (HET-P) are the two components attached by ThiE to yield thiamine phosphate, which is subsequently converted to the active form thiamine pyrophosphate (TPP). HMP and HET may be imported and converted to HMP-PP and HET-P, respectively, as an alternative to de novo biosynthesis. This property reflects known steps of HMP-P de novo biosynthesis from the purine biosynthesis metabolite aminoimidazole ribotide (AIR), starting with the ThiC enzyme. |
JCVI Role | Thiamine |
Parent Property | GenProp0261: thiamin pyrophosphate (TPP) de novo biosynthesis |
Components
Step Name | Step Num | Required | Evidence (Method) | Evidence Go Terms |
---|---|---|---|---|
ThiC protein | ThiC | YES | TIGR00190 (HMM): phosphomethylpyrimidine synthase | |
tenA domain/protein | tenA | NO | PF03070 (HMM): TENA/THI-4 family | |
phosphomethylpyrimidine kinase | thiD | YES | TIGR00097 (HMM): hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase |
Parent Properties
Accession | Name |
---|---|
GenProp0261 | thiamin pyrophosphate (TPP) de novo biosynthesis |
Sibling Properties
Accession | Name |
---|---|
GenProp0250 | thiamine: hydroxyethylthiazole from 1-deoxy-D-xylulose-5-phosphate, cysteine, either Tyr or Gly |
GenProp0254 | thiamine: TPP from HMP-PP and HET-P |