Genome Property Definition Page

Namethiamine: hydroxymethylpyrimidine pyrophosphate from aminoimidazole ribotide
DescriptionHydroxymethylpyrimidine pyrophosphate (HMP-PP) and hydroxyethylthiazole phosphate (HET-P) are the two components attached by ThiE to yield thiamine phosphate, which is subsequently converted to the active form thiamine pyrophosphate (TPP). HMP and HET may be imported and converted to HMP-PP and HET-P, respectively, as an alternative to de novo biosynthesis. This property reflects known steps of HMP-P de novo biosynthesis from the purine biosynthesis metabolite aminoimidazole ribotide (AIR), starting with the ThiC enzyme.
JCVI RoleThiamine
Parent PropertyGenProp0261: thiamin pyrophosphate (TPP) de novo biosynthesis

Step NameStep NumRequiredEvidence (Method)Evidence Go Terms
ThiC proteinThiCYESTIGR00190 (HMM): phosphomethylpyrimidine synthase
tenA domain/proteintenANOPF03070 (HMM): TENA/THI-4 family
phosphomethylpyrimidine kinasethiDYESTIGR00097 (HMM): hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase

Parent Properties
GenProp0261thiamin pyrophosphate (TPP) de novo biosynthesis

Sibling Properties
GenProp0250thiamine: hydroxyethylthiazole from 1-deoxy-D-xylulose-5-phosphate, cysteine, either Tyr or Gly
GenProp0254thiamine: TPP from HMP-PP and HET-P